[Exploration of nanofiltration conditions for separation of alcohol precipitation liquid during preparation of Reduning Injection by Box-Behnken design combined with flux attenuation].

This study employed Box-Behnken design combined with flux attenuation to explore the nanofiltration conditions for separation of alcohol precipitation liquid during the preparation of Reduning Injection and discussed the applicability of nanofiltration in the separation of the liquid with high-concentration ethanol. The effects of nanofiltration molecular weight cut-off(MWCO) and pH on the rejection of chlorogenic acid, 3,5-dicaffeoylquinic acid, and 4,5-dicaffeoylquinic acid were consistent with the principles of pore size sieving and charge effect, respectively. The rejection of the three phenolic acids was reduced by concentration polarization effect caused by trans-membrane pressure(TMP).

Improving the clarity and sensitization of polysorbate 80 by ultrasonic-assisted ultrafiltration technology.

The safety problem of injections caused by clarity has lately become a widely shared concern. Due to the synthesis process, polysorbate 80 had a wide molecular weight distribution, which is also related to the clinical anaphylaxis. In this paper, ultrasonic-assisted ultrafiltration (UAU) technology was firstly applied to regulate colloidal structure and remove macromolecules from polysorbate 80 to improve injection clarity.

[Comparison of activated carbon and ultrafiltration technique in the production process of huoxue tongluo injection].

Objective: To research the applicability of activated carbon and ultrafiltration technique in the production process of Huoxue Tongluo Injection.

Methods: The kinetic-turbidimetric method was used to determine the content of bacterial endotoxins in Huoxue Tongluo solution. Particle size change in Huoxue Tongluo solution was determined by nanometer particle size instrument before and after the use of different concentration activated carbon and different molecular weight ultrafiltration membrane.

[Speciation of inorganic elements in Chinese medicine and some factors influenced their biopharmceutical characteristics].

The paper reviews the speciation, process in vivo and biological effects of inorganic elements in Chinese medicine (CM) in the aspect of biopharmaceutics. We also summarize some factors influenced the biopharmceutical characteristics of drugs, including physical and chemical properties, formulation development, body's biological states and different actions. It is significant to safety, rationality of using of CM and modernization, internationalization of CM.