Publications by authors named "Xing-Jun Cheng"

Ionizing irradiation kills pathogens by destroying nucleic acids without protein structure destruction. However, how pathogens respond to irradiation stress has not yet been fully elucidated. Here, we observed that PAO1 could release nucleic acids into the extracellular environment under X-ray irradiation.

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Article Synopsis
  • * The study identifies key amino acids (Glu126, Glu146, Cys127, Cys131, and Cys154) that are crucial for DspI's function in synthesizing CDA.
  • * Deleting the dspI gene leads to reduced production of pyoverdine, slower movement, impaired biofilm formation, and decreased virulence of P. aeruginosa, suggesting DspI's role in the pathogen’s ability to cause infection.
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Staphylococcus aureus is a major and dangerous human pathogen that causes a range of clinical manifestations of varying severity, and is the most commonly isolated pathogen in the setting of skin and soft tissue infections, pneumonia, suppurative arthritis, endovascular infections, foreign-body associated infections, septicemia, osteomyelitis, and toxic shocksyndrome. Honokiol, a pharmacologically active natural compound derived from the bark of Magnolia officinalis, has antibacterial activity against Staphylococcus aureus which provides a great inspiration for the discovery of potential antibacterial agents. Herein, honokiol derivatives were designed, synthesized and evaluated for their antibacterial activity by determining the minimum inhibitory concentration (MIC) against S.

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Riemerella anatipestifer (R. anatipestifer) is one of the most important pathogens in ducks. The bacteria causes acute or chronic septicemia characterized by fibrinous pericarditis and meningitis.

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