Causal relationship between serum uric acid and abnormal blood pressure based on the panel model study: A 5-year cohort study.

Background And Aims: To investigate the relationship between elevated serum uric acid (SUA) levels and blood pressure (BP).

Methods And Results: Based on the Beijing Health Management Cohort, 5276 health examination people were enrolled. Cross-lagged model was used to explore the relationship between SUA levels and blood pressure.

[Effects of hydrogen sulfide on mitochondrial function in sweet cherry stigma and ovary under low temperature stress].

To investigate the effects of HS on mitochondrial functions under low temperature stress, we analyzed the effects of 0.05 mmol·L NaHS and 15 μmmol·L HT (hypotaurine and HS scavenger) on mitochondria antioxidant enzyme activities and mitochondrial permeability transition pore, mitochondrial membrane fluidity, mitochondrial membrane potential, Cyt c/a ratio and H-ATPase activity in sweet cherry stigma and ovary with sweet cherry variety Zaodaguo under -2 ℃ low temperature stress. The results showed that low temperature stress increased the concentrations of mitochondrial HO and MDA, enhanced the mitochondrial membrane permeability, but decreased the mitochondrial membrane fluidity, membrane potential, Cyt c/a and H-ATPase acti-vity.

BMI and BMI Changes to All-cause Mortality among the Elderly in Beijing: a 20-year Cohort Study.

Objective: To explore the association between body mass index (BMI) and all-cause mortality among the elderly in Beijing.

Methods: This analysis was based on the Beijing multidimensional longitudinal study of aging (BLSA), which included 2,090 subjects over 55 years old and was followed-up from 1992 to 2012. BMI-mortality curves were drawn to find the optimal BMI range with the lowest mortality.

[Estimating Surface Broadband Emissivity of the Taklimakan Desert with FTIR and MODIS Data].

Surface broadband emissivity in the thermal infrared region is an important parameteras for the studies of the surface energy balance. This paper analyzed and offered an equation to estimate the surface broadband emissivity for the spectral domains 8～14 μm against the MODIS data, and then, the distribution characteristic of surface emissivity for Taklimakan Desert was obtained with this equation. Firstly, along two highways crossing the Taklimakan Desert, twenty sample sites were selected and their spectral of broadband emissivity were observed with Fourier Transform Infrared spectrometer (FTIR).

Relationship between Migration and HIV Risky Behavior: a Comparative Study of Returning Migrants and Non Migrants Based on Rural Out-of-school Youth in Jilin, China.

Objective: To estimate the relationship between migration and HIV risky behavior when controlling for gender, age, and educational levels and to evaluate the gender differences in migration, HIV knowledge, and HIV risky behaviors among rural youth in China.

Methods: A cross-sectional, anonymous, investigative questionnaire for 1710 unmarried, out-of-school rural youth, aged between 15 and 24 years, was handed out in Gongzhuling county of Jilin province, China.

Results: 58.

[Meta-analysis of blood system adverse events of Tripterygium wilfordii].

A systematic review was undertaken, including studies that evaluated the incidence of the blood system adverse events of Tripterygium wilfordii (TWP). Medline, Embase and the Cochrane library were searched for relevant studies, including RCT, cohort studies and case series, of patients treated with TWP published in English and Chinese from inception up until May 25th, 2013 with the keywords including "Tripterygium wilfordii", "toxicity", "reproductive", "side effect", "adverse", "safety" and "tolerability". Relevant information was extracted and the incidence of the blood system adverse events was pooled with MetaAnalyst software.

MiR-138/peroxisome proliferator-activated receptor β signaling regulates human hypertrophic scar fibroblast proliferation and movement in vitro.

Excessive scars affect a patient's quality of life, both physically and psychologically, by causing pruritus, pain and contractures. Because there is a poor understanding of the complex mechanisms underlying the processes of hypertrophic scar formation, most therapeutic approaches remain clinically unsatisfactory. In this study, we found that miR-138 was downregulated and peroxisome proliferator-activated receptor (PPARβ) was inversely upregulated in hypertrophic scar tissues compared to in paired normal skin tissues.

[Reconstruction of upper lip defect].

Objective: To summarize the clinical experience for the reconstruction of upper lip defects in different degrees.

Methods: Different treatment methods were selected to reconstruct the upper lip defects according to the subunit, size or location of defects on the upper lip. The therapeutic results were analyzed and compared.

[Setting up a risk prediction model on metabolic syndrome among 35-74 year-olds based on the Taiwan MJ Health-checkup Database].

Objective: This study aimed to provide an epidemiological modeling method to evaluate the risk of metabolic syndrome (MS) development in the coming 5 years among 35-74 year-olds from Taiwan.

Methods: A cohort of 13 973 subjects aged 35-74 years who did not have metabolic syndrome but took the initial testing during 1997-2006 was formed to derive a risk score which tended to predict the incidence of MS. Multivariate logistic regression was used to derive the risk functions and using the 'check-up center' (Taipei training cohort)as the overall cohort.

An exploratory study of the association between KCNB1 rs1051295 and type 2 diabetes and its related traits in Chinese Han population.

Since the KCNB1 encoding Kv2.1 channel accounts for the majority of Kv currents modulating insulin secretion by pancreatic islet beta-cells, we postulated that KCNB1 is a plausible candidate gene for genetic variation contributing to the variable compensatory secretory function of beta-cells in type-2 diabetes (T2D). We conducted two studies, a case-control study and a cross-section study, to investigate the association of common single-nucleotide polymorphisms (SNPs) in KCNB1 with T2D and its linking traits.

[Estimation on the risk of 5-years obesity development among adults aged 30 - 59, based on the Taiwan MJ Health-checkup Database].

Objective: This study aimed to provide an epidemiological modeling in evaluating the risk of developing obesity within 5 years in Taiwan population aged 30 - 59 years.

Methods: After excluding 918 individuals who were observed at baseline, a cohort of 14 167 non-obesity subjects aged 30 - 59 years in the initial year during 1998 - 2006, was formed to derive a Risk Score which could predict the incident obesity (IO). Multivariate logistic regression was used to derive the risk functions, using the check-up center (Taipei training cohort, n = 8104) of the overall cohort.

[Regulation of peroxisome proliferator-activated receptor β by epidermal growth factor in wound tissue of mice with full-thickness skin defect].

Objective: To study the effect of freeze-dried mouse epidermal growth factor (mEGF) on the expression of peroxisome proliferator-activated receptor β (PPAR-β) in mice during wound healing.

Methods: Full-thickness skin defect with area of 1.5 cm × 1.

[Anatomic basis of the accompanying pattern of the superficial temporal arterial branches and veins and its clinical application].

Objective: To study the course of branches of the superficial temporal artery (BSTA) and the accompanying pattern of their veins in order to provide anatomic basis for flap design.

Methods: Head and facial part of ten adult corpses (19 sides) were dissected and photographed. The coordinate system was set up with external auditory foramen as the point of origin, aided by the graph analysis software Digimizer.

[Development of an indicator system for recognizing the sub-health status and study on the related reliability and validity].

Objective: To establish a subjective indicator system for the evaluation of sub-health status and study on its reliability and validity.

Methods: Based on the basic features of general malice and losing ability of workforce, the indicator system for sub-health status evaluation was developed according to the chronic stress on human body' s main systems. The items were adjusted according to the experience from experts and the results of the pilot study.

Development and evaluation of a questionnaire for measuring suboptimal health status in urban Chinese.

Background: Suboptimal health status (SHS) is characterized by ambiguous health complaints, general weakness, and lack of vitality, and has become a new public health challenge in China. It is believed to be a subclinical, reversible stage of chronic disease. Studies of intervention and prognosis for SHS are expected to become increasingly important.

[Effect of lentiviral vector encoding on triggering receptor expressed on myeloid cells 1 on expression of inflammatory cytokine in septic mice infected by Bacteroides fragilis].

Objective: To investigate the effect of triggering receptor expressed on myeloid cells 1 (TREM-1) vshRNA vector on expression of inflammatory cytokines and survival rate in septic mice infected by Bacteroides fragilis.

Methods: (1) TREM-1 vshRNA vector was constructed. Bacteroides fragilis (2.

[Repair of large defects in upper extremities with pedicled combined flap].

Objective: To explore the flap transposition for repairing large defects in upper extremities.

Methods: 12 cases with large defects in elbow, forearm, wrist or palm caused by high-voltage electricity, hot-pressure or crush, were treated. 4 cases were treated with latissimus dorsal myocutaneous flaps combined iliolumbar flaps.

[Pathological experimental study of autologous skin transplant on retained denatured dermis].

Objective: To identify the pathological character of denatured dermis,and its turnover after autologous skin transplant.

Methods: Deep partial thickness burn wounds whose diameter was 2.5 cm were produced on the back of Sprague-Dawley (SD) rats.

[Repair of high-voltage electrical burn in the neck].

Objective: To explore methods of repair of high-voltage electrical burn in the neck.

Methods: Thirty-seven patients with high-voltage electrical burn in neck hospitalized since 1985 were enrolled in this study. After debridement, the wounds were repaired with latissimus dorsi myocutaneous flap, trapezius myocutaneous flap, platysma myocutaneous flaps, pectoralis major myocutaneous flap, or latissimus dorsi myocutaneous flap combined with pectoralis major myocutaneous flap.

[Inhibitory effect of epidermal growth factor on apoptosis in HaCaT keratinocytes induced by TNF-alpha].

Objective: To explore the effect of epidermal growth factor (EGF) on apoptosis induced by TNF-alpha and the expression of PPARbeta in HaCaT keratinocytes.

Methods: HaCaT keratinocytes were cultured and randomly divided into A (normal control), B (with treatment of 10 ng/ml TNF-alpha for 24 hours), C (with treatment of 20 ng/ml TNF-alpha for 24 hours), D (with treatment of 10 ng/ml TNF-alpha after 20 ng/ml EGF treatment for 4 hours), E (with treatment of 20 ng/ml TNF-alpha after 20 ng/ml EGF treatment for 4 hours) groups. The apoptosis of HaCaT keratinocytes was observed by flow cytometry.

[The role of PPARbeta in the apoptotic HaCaT keratinocytes induced by TNF-alpha].

Objective: To explore the change of transcription activity and expression of PPARbeta in the apoptotic HaCaT keratinocytes induced by TNF-alpha.

Methods: HaCaT keratinocytes were exposed to different concentration TNF-alpha for 24 hours. Apoptotic morphological changes and percentage of apoptotic nuclei were assayed with Hoechst 33258 staining.

[Repair of the scar in the midface by skin expansion with parallel juxtaposed skin expanders].

Objective: To explore a new method for the repair of the scar in the midface.

Methods: Parallel juxtaposed expansion of the skin and soft-tissue of jaw, face, neck and posterior aspect of auricle was performed to repair the scar in the midface of 15 patients. The operation consisted of two steps.

[Study on the antisense oligonucleotide against peroxisome proliferator-activated receptors promoting TNF-alpha mediated apoptosis of HaCat cells].

Objective: To investigate the influence of antisense phosphorothioate oligonucleotides on peroxisome proliferator-activated receptors (PPARbeta) in the TNF-alpha mediated apoptosis of HaCat cells.

Methods: HaCat cells were resuscitated and randomly divided into normal control (without transfection), sham (merely with liposome transfection), scrODN (with transfection of 4 micromol/L PPARbeta scrODN), asODN (with transfection of 4 micromol/L PPARbeta asODN), TNF-alpha with transfection of 10 micromol/L TNF-alpha), scrODN + TNF-alpha with 10 micromol/L TNF-alpha stimulation after transfection of 4 micromol/L PPARbeta scrODN), asODN + TNF-alpha with 10 micromol/L TNF-alpha stimulation after transfection of 4 micromol/L PPARbeta asODN) groups. The mRNA and protein levels of PPARbeta were determined with RT-PCR and Western blotting, respectively.