-(-Methoxyphenylpropargyl) Pyrrole-2-carboxylate (PPPC) Glycosides as Donors for Glycosylation.

We developed glycosyl -(-methoxyphenylpropargyl) pyrrole-2-carboxylates (PPPCs) as highly effective donors for chemical glycosylation. The modular design and exceptional stability of the acid precursor provide PPPC donors with synthetic versatility and ease of use. Activated by NIS/TMSOTf, PPPC donors exhibit a broad compatibility for both - and -glycosylation reactions.

Mechanisms of anthraquinone dye Vat Blue 4 biodegradation by Pseudomonas aeruginosa WYT and genotoxicity assessment of its transformation products.

Dye biodegradation products may cause genotoxicity, raising concerns about the safety of bioremediated water. The underlying biotransformation mechanism and related genotoxicity during anthraquinone degradation remain unclear. In this study, we employed Pseudomonas aeruginosa WYT (PaWYT) to investigate the biotransformation of Vat Blue 4 (VB4), a dye with a typical anthraquinone structure and low bioavailability.

Harnessing street shade to mitigate heat stress: An in-situ parallel investigation under extreme heat conditions in tropical Singapore.

In the face of global rising temperatures and excessive urban heat, developing effective heat mitigation strategies has become increasingly urgent. Street shade, a typical cooling shelter for urban dwellers, has been primarily investigated for outdoor thermal comfort but not extensively under extreme heat conditions. This study explores the cooling efficacy of diverse street shade types in mitigating urban heat, thereby facilitating cities and their residents' adaptation to climatic shifts.

Pattern-based quantum text watermarking: Securing digital content with next-Gen quantum techniques.

As pioneers of next-generation watermarking technologies, quantum methods offer advanced solutions for securing digital text copyright. Quantum text representation is a prerequisite for realizing quantum watermarking. Thus we propose a generalized quantum text representation (GQTR) model for English text.

Regulated solvation structure and solid electrolyte interfaces via imidazolium ionic gel electrolytes with high Li-ion transference number for Li-metal batteries.

Solid lithium metal batteries (LMBs) are faced with problems such as the solvation structure of lithium ion and the instability of solid electrolyte interface (SEI), which lead to poor cycling stability and anode interface damage. Here, the introduced 1-ethyl-3-methylimidazolium bis(fluorosulfonyl)imide ([EMIM][FSI]) ionic liquid (IL) interacts strongly with Lithium salt to form a new ionic gel electrolyte (IGE) based on the poly (vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP), which facilitates the excellent Li-ion transference number up to 0.506 and improves the mechanical properties.

Characterization of a large caliber explosively driven shock tube.

Research on evaluating weapon systems, building structures, and personnel protection has attracted considerable attention due to the high incidence of blast accidents. The explosively driven shock tube is an affordable and replicable method for investigating high pressure blast waves and extreme shock environments. A newly constructed large caliber explosively driven shock tube with an inner diameter of 2.

Microplastic-Enhanced Cadmium Toxicity: A Growing Threat to the Sea Grape, .

The escalating impact of human activities has led to the accumulation of microplastics (MPs) and heavy metals in marine environments, posing serious threats to marine ecosystems. As essential components of oceanic ecosystems, large seaweeds such as play a crucial role in maintaining ecological balance. This study investigated the effects of MPs and cadmium (Cd) on the growth, physiology, biochemistry, and Cd accumulation in while elucidating the underlying molecular regulatory mechanisms.

Tele-rehabilitation in COVID-19 survivors (TERCOV): An investigator-initiated, prospective, multi-center, real-world study.

Introduction: Center-based rehabilitation is limited by COVID-19 infectivity and social distancing policy. We hypothesized that discharged patients benefit from 8-week home-based tele-rehabilitation (tele-PR) using mobile phones and low-cost instruments.

Methods: The TERCOV (Tele-rehabilitation in COVID-19 survivors) is an investigator-initiated, prospective, multi-center, real-world study.

Parameter Optimization of a Surface Mechanical Rolling Treatment Process to Improve the Surface Integrity and Fatigue Property of FV520B Steel by Machine Learning.

Surface integrity is a critical factor that affects the fatigue resistance of materials. A surface mechanical rolling treatment (SMRT) process can effectively improve the surface integrity of the material, thus enhancing the fatigue property. In this paper, an analysis of variance (ANOVA) and signal-to-noise ratio (SNR) are performed by orthogonal experimental design with SMRT parameters as variables and surface integrity indicators as optimization objectives, and the support vector machine-active learning (SVM-AL) model is proposed based on machine learning theory.

The synthesis and bioactivity of apigenin derivatives.

Background: Apigenin, a naturally occurring compound with a flavone core structure, is known for its diverse bioactivities, including anti-inflammation, anti-toxicant, anti-cancer and so on. There has been significant interest in the medicinal chemistry community. To address these challenges, researchers have developed various derivatives of apigenin to address challenges such as poor water-solubility and low intestinal absorption, aiming to enhance the pharmacological activities and pharmacokinetic properties of this compound.

Skeletal muscle-derived exosomes prevent osteoporosis by promoting osteogenesis.

Skeletal muscle and bone are the major organs for physical activity, in which there is a parallel correlation between muscle mass and bone density throughout a lifetime. Osteoporosis is a systemic bone metabolic disorder caused by reduced bone formation and increased bone resorption. Based on the metabolic symbiosis relationship between skeletal muscle and bone, we hypothesis that skeletal muscle secretory factors could play constructive roles in osteoporosis.

Leader Selection in Impulsive Multiagent Systems With Switching Topologies.

In leader-follower multiagent systems (MASs), seeking an efficient scheme to select a set of agents as leaders is important for realizing the expected cooperative performance. In this article, the problem of minimal leader selection is investigated for impulsive general linear MASs with switching topologies. This study focuses on selecting a set of agents as leaders that receive information from a reference signal directly, while minimizing the number of leaders, subject to consensus tracking performance.

Targeting SNRNP200-induced splicing dysregulation offers an immunotherapy opportunity for glycolytic triple-negative breast cancer.

Metabolic dysregulation is prominent in triple-negative breast cancer (TNBC), yet therapeutic strategies targeting cancer metabolism are limited. Here, utilizing multiomics data from our TNBC cohort (n = 465), we demonstrated widespread splicing deregulation and increased spliceosome abundance in the glycolytic TNBC subtype. We identified SNRNP200 as a crucial mediator of glucose-driven metabolic reprogramming.

A Study on Miniaturized In-Situ Self-Calibrated Thermometers Based on Ga and Ga-Zn Fixed Points.

In order to ensure the reliability and accuracy of long-term temperature measurement where the thermometers are discommodious or even impossible to access for conventional periodical calibration, a study on miniaturized in-situ self-calibrated (MISSC) thermometers based on Ga and Ga-Zn fixed points was conducted using temperature scale transfer technology. One MISSC thermometer consists of three parts: the first is the fixed-points hardware, including a container with two cells separately filled with Ga and Ga-Zn; the second is the temperature sensing hardware, made of a Type T thermocouple; the third is the mini-power heating hardware, made of a film resistance. The measurement and calibration (M&C) system comprises a temperature measurement and data processing subsystem and a mini-power heating control subsystem.

Insight into the role of stress response and toxic mechanism induced by Chloro-haloacetonitrile in vitro.

Chloro-haloacetonitrile (Cl-HAN), belongs to a group of nitrogenous disinfection by-products (N-DBPs) found in surface water, and are known to pose a major risk to the safety of human drinking water. However, the exact biological toxicity mechanism and the extent of the stress response caused by Cl-HAN remain unclear, resulting in a lack of effective measures to control its presence. Thus, the quantitative toxicological genomics and bioinformatics methods were applied to explore the effects of three chloro-haloacetonitriles (Cl-HANs) on the transcription of fusion genes under varying concentrations of stress in E.

Anisotropic SmFeV Bulk Magnets with Enhanced Coercivity via Ball Milling Process.

Anisotropic bulk magnets of ThMn-type SmFeV with a high coercivity () were successfully fabricated. Powders with varying particle sizes were prepared using the ball milling process, where the particle size was controlled with milling time. A decrease in occurred in the heat-treated bulk pressed from large-sized powders, while heavy oxidation excessively occurred in small powders, leading to the decomposition of the SmFeV (1-12) phase.

Segmentation and Completion of Human Motion Sequence via Temporal Learning of Subspace Variety Model.

Subspace-based models have been extensively employed in unsupervised segmentation and completion of human motion sequence (HMS). However, existing approaches often neglect the incorporation of temporal priors embedded in HMS, resulting in suboptimal results. This paper presents a subspace variety model for HMS, along with an innovative Temporal Learning of Subspace Variety Model (TL-SVM) method for enhanced segmentation and completion in HMS.

Acid-mediated strategies designed for stretchable and durable polyacrylamide/sodium alginate dual-network hydrogels toward flexible capacitors and wearable sensors.

The utilization of acid as a synthesis assistant provides an effective means to regulate the structure of hydrogels, thereby simplifying the design and preparation process of multifunctional hydrogels. However, there remains a dearth of discourse concerning the utilization of this convenient acid-mediated strategy, which possesses the potential to directly govern molecular interactions within gel networks for rational structure and property design. Herein, we describe the preparation of flexible dual-network conductive hydrogels using polyacrylamide (PAM) and sodium alginate (SA) as substrates, driven by the strategy of acid-mediated (HCI, HSO, and HCO) in detail for the first time.