Hypothetical Behavioral Interventions for Mitigating the Cardiovascular Effects of Long-Term Fine Particulate Matter Exposure: Analyses From 2 Prospective Cohorts.

Background: Whether healthy behaviors can attenuate the adverse association between ambient fine particulate matter (PM) and cardiovascular disease (CVD) is inconclusive.

Methods And Results: The parametric g-formula was used to quantify the potential reduction in PM effect on CVD under different scenarios of hypothetical behavioral interventions (including dietary patterns, physical activity, body mass index, alcohol consumption, smoking, and dietary supplements). Feasible intervention scenarios, defined on the basis of values considered feasible in previous real-world interventions (eg, overweight participants lose 6.

Bidirectional Relationships Between Sleep Quality and Cognitive Function in Older Chinese Adults: Observational Analysis of SAWA Trial.

PurposeTo examine the bidirectional relationships between sleep quality and cognitive function in older Chinese, and further examine the sex differences in the relationships using the random intercept cross-lagged panel model.DesignA secondary observational analysis of a physical activity clustered randomized controlled trial (The Stay Active While Aging).SettingEight villages in Sichuan, China.

Association Between Cardiovascular Biological Age and Cardiovascular Disease - A Prospective Cohort Study.

Background: Biological age serves as a common starting point for various age-related diseases and can be associated with a wide range of cardiovascular outcomes. However, associations between cardiovascular biological age (CBA) and various types of cardiovascular disease (CVD) remain unclear.

Methods And Results: Analyzing 262,343 UK Biobank participants, we constructed CBA based on composite biomarkers using the Klemera-Doubal method (denoted as KDM-CBA).

Enhancing Osteogenesis through Bio-Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production.

Bio-inspired coral-derived scaffolds have been adopted for bone regeneration. However, these confront challenges such as the limited osteoinductive properties, environmental concerns, and ambiguous calcification mechanisms in coral proteins. In this study, the role of the recombinant coral protein galaxin in promoting osteogenesis is investigated.

Lifestyles and their relative contribution to biological aging across multiple-organ systems: Change analysis from the China Multi-Ethnic Cohort study.

Background: Biological aging exhibits heterogeneity across multi-organ systems. However, it remains unclear how is lifestyle associated with overall and organ-specific aging and which factors contribute most in Southwest China.

Methods: This study involved 8396 participants who completed two surveys from the China Multi-Ethnic Cohort (CMEC) study.

Occult epidermal growth factor receptor-mutant lung adenocarcinoma complicated by prostatic metastasis: a case report.

Herein, we report a case of occult epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma complicated by prostatic metastasis. A 75-year-old male with >30 years of smoking history presented with lower back pain as the initial symptom. Respiratory symptoms, including cough and sputum production, were absent.

Low dose computed tomography reconstruction with momentum-based frequency adjustment network.

Background And Objective: Recent investigations into Low-Dose Computed Tomography (LDCT) reconstruction methods have brought Model-Based Data-Driven (MBDD) approaches to the forefront. One prominent architecture within MBDD entails the integration of Model-Based Iterative Reconstruction (MBIR) with Deep Learning (DL). While this approach offers the advantage of harnessing information from sinogram and image domains, it also reveals several deficiencies.

Deformation and Fracture Behaviour of Heterostructure Mn8/SS400 Bimetal Composite.

This study examines the deformation behaviour and fracture mechanisms of bimetal composites (BCs) composed of high-carbon medium-manganese steel (Mn8) and low-carbon steel (SS400), fabricated through hot roll bonding. The research highlights the effect of varying thickness ratios on the mechanical properties of Mn8/SS400 BCs. The microstructure and interfacial characteristics were analysed using scanning electron microscopy (SEM), revealing a well-bonded and defect-free interface with distinct elemental distributions.

MiR-451 in Inflammatory Diseases: Molecular Mechanisms, Biomarkers, and Therapeutic Applications-A Comprehensive Review Beyond Oncology.

MicroRNAs play crucial roles in regulating inflammatory responses and disease progression. Since its identification on chromosome 17q11.2 in 2005, miR-451 has emerged as a key regulator of multiple physiological and pathological processes.

Selecting projection views based on error equidistribution for computed tomography.

Background: Nonuniform sampling is a useful technique to optimize the acquisition of projections with a limited budget. Existing methods for selecting important projection views have limitations, such as relying on blueprint images or excessive computing resources.

Methods: We aim to develop a simple nonuniform sampling method for selecting informative projection views suitable for practical CT applications.

hBN/TiO water-based nanolubricants: a solution for stick-slip mitigation in tribological applications.

In this study, the stick-slip behaviour of synthesised water-based nanolubricants was investigated an Rtec ball-on-disk tribometer. By varying the lubricating conditions, including the concentration of hBN/TiO as nanoadditives, the tribological properties and lubrication mechanisms were analysed, especially the stick-slip phenomenon. Compared with dry and wet conditions, the hBN/TiO nanolubricant presented better efficiency in mitigating stick-slip and achieving friction stability.

Changes in drinking levels and metabolic dysfunction-associated steatotic liver disease: a longitudinal study from the China multi-ethnic cohort study.

Background: Little is known about the associations of changes in drinking levels with the newly defined metabolic dysfunction-associated steatotic liver disease (MASLD). We therefore sought to estimate the associations between changes in drinking levels and MASLD in less developed regions of China.

Methods: This longitudinal study included 8727 participants from the China Multi-Ethnic Cohort (CMEC) in less developed regions, all participating in baseline and a follow-up survey.

Population-level gut microbiome and its associations with environmental factors and metabolic disorders in Southwest China.

Gut microbiota affects host health and disease. Large-scale cohorts have explored the interactions between the microbiota, host, and environment to reveal the disease-associated microbiota variation. A population-level gut metagenomic cohort is still rare in China.

PSLFM: a single-frame uncalibrated photometric stereoscopic light field measurement scheme based on dense convolutional neural networks.

In the realm of 3D measurement, photometric stereo excels in capturing high-frequency details but suffers from accumulated errors that lead to low-frequency distortions in the reconstructed surface. Conversely, light field (LF) reconstruction provides satisfactory low-frequency geometry but sacrifices spatial resolution, impacting high-frequency detail quality. To tackle these challenges, we propose a photometric stereoscopic light field measurement (PSLFM) scheme that harnesses the strengths of both methods.

Color-multiplexed 3D differential phase contrast microscopy with optimal annular illumination.

Quantitative phase imaging (QPI) has become a valuable tool in the field of biomedical research due to its ability to quantify refractive index variations of live cells and tissues. For example, three-dimensional differential phase contrast (3D DPC) imaging uses through-focus images captured under different illumination patterns deconvoluted with a computed 3D phase transfer function (PTF) to reconstruct the 3D refractive index. In conventional 3D DPC with semi-circular illumination, partially spatially coherent illumination often diminishes phase contrast, exacerbating inherent noise, and can lead to a large number of zero values in the 3D PTF, resulting in strong low-frequency artifacts and deteriorating imaging resolution.

[Anterior approach for the revision surgery following bone cement augmentation in osteoporotic vertebral compression fractures].

Objective: To observe the clinical outcomes of anterior approach for the revision surgery following unsuccessful bone cement augmentation in osteoporotic vertebral compression fractures.

Methods: A total of 10 patients who experienced unsuccessful bone cement augmentation underwent anterior revision surgery between January 2020 and December 2021. There were 2 males and 8 females.

NAA enhances armillaria gallica growth by modulating nitrogen metabolism through AgZFP48.

Armillaria gallica (A. gallica) is a fungus with both medicinal and edible properties. Previous transcriptome analysis has identified the C2H2-type zinc finger transcription factor as a candidate gene involved in the NAA-induced growth promotion of A.

Aucubin Promotes BMSCs Proliferation and Differentiation of Postmenopausal Osteoporosis Patients by Regulating Ferroptosis and BMP2 Signalling.

Postmenopausal osteoporosis (PMOP) is a chronic systemic bone metabolism disorder. Promotion in the patterns of human bone marrow mesenchymal stem cells (hBMSCs) differentiation towards osteoblasts contributes to alleviating osteoporosis. Aucubin, a natural compound isolated from the well-known herbal medicine Eucommia, was previously shown to possess various pharmacological effects.

Identification and validation of the important role of KIF11 in the development and progression of endometrial cancer.

Background: Human kinesin family member 11 (KIF11) plays a vital role in regulating the cell cycle and is implicated in the tumorigenesis and progression of various cancers, but its role in endometrial cancer (EC) is still unclear. Our current research explored the prognostic value, biological function and targeting strategy of KIF11 in EC through approaches including bioinformatics, machine learning and experimental studies.

Methods: The GSE17025 dataset from the GEO database was analyzed via the limma package to identify differentially expressed genes (DEGs) in EC.

Analysis of the miRNA Transcriptome in and Its Regulation of Diterpenoid Alkaloid Biosynthesis.

() is an important medicinal plant in the Aconitum genus that is known for its diterpenoid alkaloids, which exhibit significant pharmacological activity and toxicity, thus making it valuable for both medicinal use and as a biopesticide. Although the biosynthesis of terpenoids is well characterized, the potential gene regulatory role of microRNAs (miRNAs) in terpenoid biosynthesis in remains unclear, and further research is needed to explore this aspect in this species. In this study, miRNA sequencing was conducted to analyze the miRNA population and its targets in .

Amelioration of Inflammation in Rats with Experimentally Induced Asthma by Trimen Polyphenols via the PI3K/Akt Signaling Pathway.

Asthma is a chronic inflammatory respiratory disease that affects millions globally and poses a serious public health challenge. Current therapeutic strategies, including corticosteroids, are constrained by variable patient responses and adverse effects. In this study, a polyphenolic extract derived from the Tibetan medicinal plant Trimen (SRT) was employed and shown to improve experimentally (ovalbumin + cigarette smoke, OVA + CS) induced asthma in rats.

Intravenous administration of mitochondria improves ovarian function by anti-apoptosis in the premature ovarian insufficiency model.

Objective: For patients with contraindications to hormone therapy, the absence of effective treatments for ovarian dysfunction post chemotherapy represents a critical issue requiring resolution. Local administration of mitochondria may enhance ovarian function in premature ovarian insufficiency (POI) by ameliorating diminished mitochondrial activity. Nevertheless, there is a paucity of literature on the efficacy of mitochondrial transplantation through intravenous injection, a less invasive and more convenient method than local injection, for the improvement of ovarian function in POI following chemotherapy.

Regulation of T Cell Glycosylation by MXene/β-TCP Nanocomposite for Enhanced Mandibular Bone Regeneration.

Immune-mediated bone regeneration driven by bone biomaterials offers a therapeutic strategy for repairing bone defects. Among 2D nanomaterials, TiCT MXenes have garnered substantial attention for their potential in tissue regeneration. This investigation concentrates on the role of MXene nanocomposites in modulating the immune microenvironment within bone defects to facilitate bone tissue restoration.

Synergistic Optimization of Buried Interface via Hydrochloric Acid for Efficient and Stable Perovskite Solar Cells.

Incorporating chlorine into the SnO electron transport layer (ETL) has proven effective in enhancing the interfacial contact between SnO and perovskite in perovskite solar cells (PSCs). However, previous studies have primarily focused on the role of chlorine in passivating surface trap defects in SnO, without considering its influence on the buried interface. Here, hydrochloric acid (HCl) is introduced as a chlorine source into commercial SnO to form Cl-capped SnO (Cl-SnO) ETL, aiming to optimize the buried interface of the PSC.

[Characteristics and treatment measures of cages displacement after oblique lateral interbody fusion].

Objective: To explore characteristics, management strategies and preventive measures of fusion device displacement after oblique lateral interbody fusion (OLIF) in treating lumbar lesions.

Methods: The clinical data of 12 patients with fusion device displacement after OLIF for lumbar lesions in 4 medical centers from October 2014 to December 2018 were retrospectively analyzed, including 4 males and 8 females, aged from 53 to 81 years old;2 patients with lumbar disc degeneration, 4 patients with lumbar spinal stenosis, 3 patients with lumbar degenerative spondylolisthesis and 3 patients with lumbar degenerative kyphosis;preoperative dual-energy X-ray bone mineral density (BMD) was detected in 1 patient with T-value > -1 SD, 5 patients with T-value >-1~-2.5 SD, and 6 patients with T-value <-2.