Non-pharmacological treatment strategies for anthropometric, physical capacity and physiological indicators among sarcopenic obesity patients: a systematic review of rigorous randomized controlled trials.

Objectives: To investigate the effects of non-pharmacological treatments on sarcopenic obesity (SO).

Methods: A search for randomized controlled trials (RCTs) on SO was conducted in PubMed, Web of Science, CINAHL, CENTRAL, SPORTDiscus, CNKI, Wanfang and VIP. A meta-analysis was conducted using random-effects models for MDs.

Metal-organic framework-based nanoplatforms for synergistic anti-atherosclerosis therapy by regulating the PI3K/AKT/MSR1 pathway in macrophages.

Atherosclerosis is the main pathogenic factor of various cardiovascular diseases. During the pathogenesis of atherosclerosis, macrophages play a major role, mainly by secreting pro-inflammatory cytokines and taking in lipids to form foam cells. Thiamine pyrophosphate (TPP) is an antagonist of the P2Y6 receptor, which is overexpressed on macrophages during atherosclerosis and facilitates the lipid phagocytosis of macrophages.

First metagenomic sequencing for the analysis of microbial community populations of adults and pupae of in Xinjiang, China.

Introduction: , a parasite on the body surface of sheep, directly attacks the host through biting and sucking blood and may also transmit pathogens in the process. There are currently only a few studies on the microbial composition of , while there are no such studies on pupae.

Methods: In this study, samples AT-1 to AT-4 each contained four individuals, while sample AT-5 comprised four pupae, all used for metagenomic sequencing and analysis.

Effects of Drought on the Water Use Strategies of Pure and Mixed Shrubs in the Mu Us Sandy Land.

Water resources are crucial factors that limit vegetation recovery, and rational planning of silvicultural patterns is essential for the efficient utilization of water in arid and semi-arid regions. This study examined the water utilization strategies of pure shrubs (pure stands of and pure stands of ) and mixed shrubs (mixed stands of , and mixed stands of ) from the rainy to dry seasons using stable isotope techniques and MixSIAR modeling in the Mu Us Sandy Land in the semi-arid region of China. Mixed shrubs were significantly more effective than pure shrubs in utilizing the primary water sypply from the soil layer.

The regular effects of concurrent aerobic and resistance exercise on global cognition in healthy elderly populations: A systematic review with meta-analysis of randomized trials.

Aerobic and resistance exercises are widely recognized as essential for preserving and enhancing cognitive function. However, the effects of concurrent exercise on cognition in older adults remain unclear. This systematic review sought to evaluate the regular effects of concurrent aerobic and resistance training on global cognition in healthy older adults.

Molecular characterization of a novel victorivirus isolated from Stagonosporopsis citrulli.

Members of the fungal genus Stagonosporopsis are important plant pathogens that can cause severe disease on a wide range of economically important plants and crops. Here, a novel victorivirus, tentatively named "Stagonosporopsis citrulli victorivirus 1" (SciVV1), was isolated from S. citrulli isolate HS2-8.

Engineered β1-3--Acetylglucosaminyltransferase Facilitating the One-Pot Multienzyme Synthesis of Human Milk Oligosaccharides.

β1-3-linked -acetylglucosaminide is a prevalent carbohydrate motif found in oligosaccharides, polysaccharides, glycoproteins, and glycolipids. It is a crucial component of human milk oligosaccharides (HMOs). β1-3--acetylglucosaminyltransferase (NmLgtA) catalyzes the formation of a glycosidic bond and has the potential for use in synthesizing HMOs.

Modulation of the hepatic RANK-RANKL-OPG axis by combined C5 and CD14 inhibition in a long-term polytrauma model.

Background: Polytrauma and hemorrhagic shock can lead to direct and indirect liver damage involving intricate pathophysiologic mechanisms. While hepatic function has been frequently highlighted, there is minimal research on how the receptor activator of the NF-κB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system is regulated in the liver following trauma. Furthermore, cross-talking complement and toll-like-receptor (TLR) systems can contribute to the posttraumatic response.

Exploring the effects of perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) on silkworm from the insights of metabolome.

Perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) are emerging environmental contaminants with recognized potential health and ecological risks. This study investigated the effects of PFOA and TBBP-A exposure on the global of metabolites of silkworm gut with GC-MS metabolomics. Our results revealed distinct metabolic alterations in silkworms exposed to PFOA and TBBP-A, highlighting their differential impacts on silkworm health and productivity.

Leaf nutrient traits exhibit greater environmental plasticity compared to resource utilization traits along an elevational gradient.

Studying key leaf functional traits is crucial for understanding plant resource utilization strategies and growth. To explore the patterns and driving factors of key leaf functional traits in forests along elevational gradients under global change, we collected survey data from 697 forests across China from 2008 to 2020. This study examined the elevational patterns of Specific Leaf Area (SLA, m²/kg), Leaf Dry Matter Content (LDMC, g/g), Leaf Nitrogen (LN, mg/g), and Leaf Phosphorus (LP, mg/g), and their responses to climate, soil nutrients, and stand factors.

Elevated lipid accumulation product trajectory patterns are associated with increasing incident risk of type 2 diabetes mellitus in China.

Purpose: Our study aimed to identify the trajectory patterns of lipid accumulation product (LAP) and investigate their association with the incident risk of type 2 diabetes mellitus (T2DM) in China.

Methods: This study included 37,316 eligible participants, with data collected between1998 and 2021. The LAP trajectory patterns were identified through latent mixture modeling.

Manganese-doped carbon dots with catalase-like activity enable MRI-guided enhanced photodynamic therapy.

The tumor microenvironment (TME) exhibits characteristics such as hypoxia, weak acidity, and enrichment of glutathione and hydrogen peroxide (HO), which greatly limits the effectiveness of tumor magnetic resonance imaging (MRI) and photodynamic therapy (PDT). Carbon dots (CDs) nanozymes are excellent candidate materials with both diagnostic and therapeutic potential. However, CDs nanozymes with both ultra-high relaxation rate and good therapeutic effect are still to be developed.

DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy.

Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are common X-inherited neuromuscular diseases. The genetic diagnosis has been used as the diagnostic choice for DMD/BMD. The study subjects consisted of 37 patients from Southwest China.

The Development and Validation of an Artificial Intelligence Chatbot Dependence Scale.

In recent years, a plethora of artificial intelligence (AI) chatbots have been developed and made available to the public. Consequently, an increasing number of individuals are integrating AI chatbots into their daily lives for various purposes. This trend has also raised concerns regarding AI chatbot dependence.

Effects of Integrating Stair Climbing-Based Exercise Snacks Into the Campus on Feasibility, Perceived Efficacy, and Participation Perspectives in Inactive Young Adults: A Randomized Mixed-Methods Pilot Study.

This 6-week pilot study aimed to investigate the feasibility, perceived efficacy, and participation perspectives of a university campus stair climbing-based exercise snack (ES) intervention and to compare it to moderate-intensity continuous training (MICT). Healthy, young, inactive adults (age: 21.6 ± 2.

Bioorthogonally activated probes for precise fluorescence imaging.

Over the past two decades, bioorthogonal chemistry has undergone a remarkable development, challenging traditional assumptions in biology and medicine. Recent advancements in the design of probes tailored for bioorthogonal applications have met the increasing demand for precise imaging, facilitating the exploration of complex biological systems. These state-of-the-art probes enable highly sensitive, low background, imaging of biological species and events within live organisms, achieving resolutions comparable to the size of the biomolecule under investigation.