Orthopedic surgical robotic systems in knee arthroplasty: a comprehensive review.

In conjunction with the accelerated evolution of robotics, the advancement of robot-assisted minimally invasive surgical systems is occurring at a similarly accelerated pace, and is becoming increasingly accepted. It is employed in numerous surgical specialties, including orthopedics, and has significantly transformed traditional surgical techniques. Among these applications, knee arthroplasty represents one of the most prevalent and efficacious procedures within the domain of robot-assisted orthopedic surgery.

Preoperative Planning and Experimental Validation for Robot-Assisted Minimally Invasive Surgery Based on a Clinical Evaluation System.

Background: Robot-assisted minimally invasive surgery has effectively addressed the challenges faced by traditional minimally invasive surgery. Well-designed preoperative planning is crucial for robot-assisted minimally invasive surgery.

Methods: This paper proposes a preoperative planning method based on a clinical evaluation system.

Integrating circular economy policies in urban policy making: Strategies for green energy and environmental management to reinforce city image in China.

The implementation of circular economy (CE) policies in the management of urban policies have become essential for improving overall quality of life, development of green energy, and environmental management hence improving the image of cities. This research focuses on uncovering the core concepts of CE within urban environments, emphasizing actions that can improve green energy and environmental management. The CE aims to create a closed-loop system by prioritizing practices like remanufacturing, reusing, and recycling, which collectively help decrease resource usage and limit environmental damage.

Mo-O-Sn Bond Boosting Kinetics of MoO-xSnO/Sn Anode for High-Performance Li-ion Batteries.

Obtaining a robust electrode composed of Sn-based metal oxides and carbonaceous matrix through nanoscale structure engineering is essential for effectively improving Li-ion batteries' electrochemical performance and stability. Herein, we report a bimetallic MoO-xSnO/Sn nanoparticles uniformly anchored on N, S co-doped graphene nanosheets (MoO-xSnO/Sn@NSG) as an anode electrode for Li-ion battery via a one-step hydrothermal and thermal treatment approach. In the MoO-xSnO/Sn nanocomposite, the generated Sn-O-Mo bond can modulate the electronic and composition structures to improve the intrinsic conductivity of SnO and reinforce the structural stability during cycles.

Effect of tirofiban combined with endovascular treatment on hemorrhagic transformation and neurological function in patients with ischemic stroke.

Objective: To evaluate the effect of Tirofiban combined with endovascular treatment on hemorrhagic transformation (HT) and neurological function in patients with ischemic stroke.

Methods: A retrospective analysis was performed on 94 patients with ischemic stroke treated at Xi'an International Medical Center Hospital from January 2020 to January 2023. Among them, 45 patients underwent endovascular treatment only and served as the control group.

Dominant atmospheric circulation patterns associated with the rapid intensification of summer flash droughts in Eastern China.

Flash droughts (FDs), which are characterized by rapid intensification, occurred frequently over Eastern China, posing great challenges for drought forecasting and preparation on subseasonal timescale. However, the drivers of the rapid development of FDs are not well understood. By comparing with slow droughts (SDs), this study investigates the dominant physical processes responsible for FDs in four different regions over Eastern China through diagnosing moisture budgets and further linking them to large-scale atmospheric circulation patterns.

Clinical Features and Electroencephalogram Analysis of Brain Network Functional Connectivity in Anti-Leucine-Rich Glioma-Inactivated 1 Antibody Encephalitis.

Purpose: To summarize the clinical manifestations, laboratory findings, and magnetic resonance imaging (MRI) characteristics of anti-leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis (anti-LGI1 antibody encephalitis) and explore the electroencephalogram (EEG) features.

Patients And Methods: We retrospectively analyzed the medical history of 16 patients diagnosed with anti-LGI1 antibody encephalitis at the First Hospital of Hebei Medical University from 2021 to 2023. EEGs of patients with anti-LGI1 antibody encephalitis and healthy individuals were analyzed.

Color and fluorescence orthogonal dual-functional visual turn-on sensing for acidic and alkaline glyphosate and additive.

In this work, benefitting from the sensitive pH-responsiveness of both meso-tetra-(4-sulfonatophenyl) porphyrin (TPPS) and calixpyridinium, and their controllable strong noncovalent interactions, the first orthogonal dual-functional visual sensor for simultaneously and separately detecting acidic and alkaline substances without interference by using UV-Vis absorption and fluorescence emission spectra with both "turn on" signal changes was constructed by the supramolecular assembly of calixpyridinium with TPPS. Color and fluorescence orthogonal dual-functional visual "turn-on" sensing for acidic and alkaline glyphosate and additive by calixpyridinium-TPPS sensor was further practically applied. The preparation of this sensor is quite simple in an environmentally friendly water medium.

Evaluating the efficacy of transcranial direct current stimulation for refractory epilepsy: A meta-analysis of RCTs and non-RCTs.

An increasing number of research indicate that non-invasive neurostimulation techniques, like transcranial direct current stimulation (tDCS), can effectively control refractory epilepsy. While previous meta-analyses have primarily focused on randomized controlled trials (RCTs), this study expands the scope by including both RCTs and non-RCTs to provide a more comprehensive assessment of tDCS efficacy in treating refractory epilepsy. Through a systematic search of "PUBMED, Embase and Cochrane", we sought relevant studies related to the research topic.

Cyclodextrin-Containing Drug Delivery Systems and Their Applications in Neurodegenerative Disorders.

Cyclodextrins (CDs) are ubiquitous excipients, constituted of cyclic glucopyranose units, and possess a unique dual nature, that of a hydrophobic interior and a hydrophilic exterior. This enables their interaction with lipid-affinitive compounds and hydrophilic compounds, thereby augmenting their application in pharmaceutical formulations as agents for improving solubility, as well as fundamental elements of advanced drug delivery systems. Additionally, CDs, upon suitable modification, can strategically participate in the interaction with cellular components and physical barriers, such as the blood-brain barrier, where their intricate and multifunctional engagement leads to various biological impacts.

EGFR-Tyrosine Kinase Inhibitor Combined with Radiotherapy in 105 Patients of Lung Adenocarcinoma with Brain Metastasis: A Retrospective Study of Prognostic Factor Analysis.

Introduction: This study aimed to retrospectively analyse the response and prognosis factors for patients with lung adenocarcinoma exhibiting brain metastasis and epidermal growth factor receptor (EGFR) mutations, who were treated with a combination of EGFR-tyrosine kinase inhibitor (TKI) and brain radiotherapy (RT).

Methods: Clinicopathological data of patients with lung adenocarcinoma were collected from January 2021 to January 2024 at the First Affiliated Hospital of Hebei North University. Statistical analysis was performed using SPSS version 26.

Promoting C-Cl Bond Activation via a Preoccupied Anchoring Strategy on Vanadia-Based Catalysts for Multi-Pollutant Control of NO and Chlorinated Aromatics.

Regulating vanadia-based oxides has been widely utilized for fabricating effective difunctional catalysts for the simultaneous elimination of NO and chlorobenzene (CB). However, the notorious accumulation of polychlorinated species and excessively strong NH adsorption on the catalysts lead to the deterioration of multipollutant control (MPC) activity. Herein, protonated sulfate (-HSO) supported on vanadium-titanium catalysts via a preoccupied anchoring strategy are designed to prevent polychlorinated species and alleviate NH adsorption for the multipollutant control.

Efficacy and safety of mesenchymal stem cell therapies for ischemic stroke: a systematic review and meta-analysis.

Background: The efficacy and safety of mesenchymal stem cells (MSCs) in the treatment of ischemic stroke (IS) remains controversial. Therefore, this study aimed to evaluate the efficacy and safety of MSCs for IS.

Methods: A literature search until May 23, 2023, was conducted using PubMed, EMBASE, the Cochrane Library, and the Web of Science to identify studies on stem cell therapy for IS.

Intervertebral Disc-on-a-Chip: A New Model for Mouse Disc Culture via Integrating Mechanical Loading and Dynamic Media Flow.

This study aims to develop an organ-on-a-chip model, intervertebral Disc-on-a-Chip, to investigate integrated effects of mechanical loading and nutrition on disc health. The system consists of a detachable multilayer microfluidic chip, a Computer-Arduino-based control system, and a mechanical loading unit, which were optimized for accurate axial force measurement and the maintenance of a 21-day disc culture. To ensure accuracy of axial force, we optimized the axial mechanical loading regimen, used the Computer-Arduino-based system and low-profile force sensors (LPFS) to control the mechanical loading unit, and modeled the force distribution by using computational simulation.

Inhibition of YIPF2 Improves the Vulnerability of Oligodendrocytes to Human Islet Amyloid Polypeptide.

Excessive secretion of human islet amyloid polypeptide (hIAPP) is an important pathological basis of diabetic encephalopathy (DE). In this study, we aimed to investigate the potential implications of hIAPP in DE pathogenesis. Brain magnetic resonance imaging and cognitive scales were applied to evaluate white matter damage and cognitive function.

Implementing nursing interventions based on stress system theory alongside painting therapy for pediatric post-traumatic stress disorder following accidental injury.

Objective: The aim of this study is to examine the impact of a nursing intervention based on stress system theory, coupled with painting therapy, on children experiencing post-traumatic stress disorder (PTSD) subsequent to an accidental injury.

Methods: The clinical data of 100 children diagnosed with PTSD following accidental injuries were retrospectively analyzed for the period spanning April 2021 to May 2023. There were 48 children who received standard nursing care between April 2021 and April 2022 in the control group, and 52 children who received nursing intervention based on stress system theory combined with painting therapy between May 2022 and May 2023 in the observation group.

Study on the influence of rock bridge angle on the size effect of rock uniaxial compression.

As a basic parameter of rock, the rock bridge angle plays an important role in maintaining the stability of rock masses. To study the size effect of rock bridge angle on the uniaxial compressive strength of rocks, this paper adopts the principle of regression analysis and combines numerical simulation to carry out relevant research. The research results indicate that: (1) the uniaxial compressive strength decreases with the increase of the rock bridge angle, showing a power function relationship; (2) The uniaxial compressive strength decreases with the increase of rock size and tends to stabilize when the rock size is greater than 350 mm, showing a significant size effect.

Exposure to Polybrominated Diphenyl Ethers and Risk of All-Cause and Cause-Specific Mortality.

Importance: Polybrominated diphenyl ethers (PBDEs) are an important group of persistent organic pollutants with endocrine-disrupting properties. However, prospective cohort studies regarding the association of PBDE exposure with long-term health outcomes, particularly mortality, are lacking.

Objective: To examine the association of environmental exposure to PBDEs with risk of all-cause and cause-specific mortality.

Bacteria Synergized with PD-1 Blockade Enhance Positive Feedback Loop of Cancer Cells-M1 Macrophages-T Cells in Glioma.

Cancer immunotherapy is an attractive strategy because it stimulates immune cells to target malignant cells by regulating the intrinsic activity of the immune system. However, due to lacking many immunologic markers, it remains difficult to treat glioma, a representative "cold" tumor. Herein, to wake the "hot" tumor immunity of glioma, Porphyromonas gingivalis (Pg) is customized with a coating to create an immunogenic tumor microenvironment and further prove the effect in combination with the immune checkpoint agent anti-PD-1, exhibiting elevated therapeutic efficacy.

Transcranial direct current stimulation for upper extremity motor dysfunction in poststroke patients: A systematic review and meta-analysis.

Objective: To evaluate the efficacy and safety of transcranial direct current stimulation in poststroke patients with upper extremity motor dysfunction using a systematic review and meta-analysis.

Data Sources: We searched the Web of Science, Cochrane Library, EMBASE, and PubMed for randomized controlled trials investigating the effects of both active and sham stimulation up until January 27, 2024.

Review Methods: Efficacy, including the upper extremity Fugl-Meyer Assessment, Action Research Arm Test, Barthel Index, and safety, were assessed.

Fenofibrate alleviates NAFLD by enhancing the PPARα/PGC-1α signaling pathway coupling mitochondrial function.

Background: To comprehend the influences of fenofibrate on hepatic lipid accumulation and mitochondrial function-related signaling pathways in mice with non-alcoholic fatty liver disease (NAFLD) secondary to high-fat diets together with free fatty acids-influenced HepG2 cells model.

Materials And Methods: A random allocation of male 6-week C57BL/6J mice into three groups was done, including controls, model (14 weeks of a high-fat diet), and fenofibrate [similar to the model one with administered 0.04 g/(kg.

In Situ S-Doping Engineering for Highly Efficient NH-SCR over Metal-Free Carbon Catalysts: A Novel Synergetic Promotional Mechanism.

Cyclic desulfurization-regeneration-denitrification based on metal-free carbon materials is one of the most promising ways to remove NO and SO simultaneously. However, the impact of S-doping induced by the cyclic desulfurization and regeneration (C-S-R) process on the selective catalytic reduction (SCR) is not well understood. Herein, it is demonstrated that the C-S-R process at 500 °C induces in situ S-doping with a significant accumulation of C-S-C structures.

Single-cell map of dynamic cellular microenvironment of radiation-induced intestinal injury.

Intestine is a highly radiation-sensitive organ that could be injured during the radiotherapy for pelvic, abdominal, and retroperitoneal tumors. However, the dynamic change of the intestinal microenvironment related to radiation-induced intestine injury (RIII) is still unclear. Using single-cell RNA sequencing, we pictured a dynamic landscape of the intestinal microenvironment during RIII and regeneration.

Monthly variations of groundwater arsenic risk under future climate scenarios in 2081-2100.

The seasonal variations of shallow groundwater arsenic have been widely documented. To gain insight into the monthly variations and mechanisms behind high groundwater arsenic and arsenic exposure risk in different climate scenarios, the monthly probability of high groundwater arsenic in Hetao Basin was simulated through random forest model. The model was based on arsenic concentrations obtained from 566 groundwater sample sites, and the variables considered included soil properties, climate, topography, and landform parameters.

Validation of a training system for laparoscopic longitudinal suturing in lesion.

Background: A training system that allows the trainee to perform laparoscopic suturing in a realistic environment and measures the force applied to the tissue would be invaluable. This study aims to establish the construct and content validity of the training system we developed for the objective assessment of surgeons' skills.

Methods: Ten novices, 6 residents, and 6 experts performed the suturing and knot-tying task using the training system.