[Digital Intelligence Drives the High-Quality Development of the Healthcare Service System: Development Mechanisms and Implementation Pathway].

The rapid development of digital intelligence technologies is providing a powerful boost to the high-quality development of the healthcare system. Considering the current state of our healthcare services and guided by General Secretary Xi Jinping's insights on new quality productive forces and the directives from Third Plenary Session of Communist Party of China's 20th Central Committee, the high-quality development of the healthcare service system should focus on digital intelligence technologies such as cloud computing, big data, privacy computing, blockchain, Internet of Things (IoT), mobile computing, and AI. The key measures should include the optimization of production factors, services, and governance.

Utilization of, Perceptions on, and Intention to Use AI Chatbots Among Medical Students in China: National Cross-Sectional Study.

Background: Artificial intelligence (AI) chatbots are poised to have a profound impact on medical education. Medical students, as early adopters of technology and future health care providers, play a crucial role in shaping the future of health care. However, little is known about the utilization of, perceptions on, and intention to use AI chatbots among medical students in China.

Chewing difficulties mediated association between edentulism and depressive symptoms among middle aged and older population.

Background: Depression is a major health condition among the aging population. Previous studies indicated that edentulism was a risk factor for depression. The link between edentulism and depression has not been fully clarified.

[Reflections on the Implications of the Developments in ChatGPT for Changes in Medical Education Models].

Ever since its official launch, Chat Generative Pre-Trained Transformer, or ChatGPT, a natural language processing tool driven by artificial intelligence (AI) technology, has attracted much attention from the education community. ChatGPT can play an important role in the field of medical education, with its potential applications ranging from assisting teachers in designing individualized teaching scenarios to enhancing students' practical ability for solving clinical problems and improving teaching and research efficiency. With the developments in technology, it is inevitable that ChatGPT, or other generative AI models, will be thoroughly integrated in more and more medical contexts, which will further enhance the efficiency and quality of medical services and allow doctors to spend more time interacting with patients and implement personalized health management.

C-Alkylated flavonoids from the whole plants of Desmodium caudatum and their anti-TMV activity.

Background: Natural products are important sources of biopesticides to control plant virus, and flavonoids are identified as promising anti-tobacco mosaic virus (TMV) agents. Since Desmodium caudatum is a rich source of flavonoids, this study focuses on the discovery of the new anti-TMV active flavonoids from D. caudatum and their possible mode of action.

Flexible and simple telecentric camera calibration method.

The measurement accuracy of telecentric imaging technique straightforwardly depends on the calibration of the telecentric camera. We present a flexible and simple calibration method based on a telecentric imaging model and orthogonality of rotation matrix. First, we use the orthogonality of rotation matrix to solve the magnification.

Self-reported visual impairment and depression of middle-aged and older adults: The chain-mediating effects of internet use and social participation.

Background: Visual impairment (VI) is a strong predictor of depression in middle-aged and older adults. However, the underlying mechanisms and pathways have not been well characterized. The purpose of this study was to determine whether Internet use and social participation mediate the effects of self-reported VI on depression.

Prediction model for early childhood caries risk based on behavioral determinants using a machine learning algorithm.

Background: An easily accessible caries risk prediction model (CRPM) based on nonbiological predictors is lacking. Developing a CRPM for community screening is essential for children's dental health promotion by a public health approach.

Objective: This study aimed to develop and validate a caries risk prediction model (CRPM) for children using a machine learning algorithm based on dental care behavioral factors and other nonbiological factors using a 3-month multicenter cohort.

Caries Risk Assessment and Dental Referral by Paediatric Primary Care Physicians in Sichuan Province, China: A Cross-Sectional Study.

Background: Limited information is known about dental implementation by pediatric primary care physicians (PCPs) at the primary care level in China. This study aimed to explore the current status of primary oral care implementation and related influencing factors.

Methods: A cross-sectional survey was conducted among PCPs in Sichuan Province, China.

Effect of the COVID-19 Mitigation Measure on Dental Care Needs in 17 Countries: A Regression Discontinuity Analysis.

Objectives: The effect of COVID-19 mitigation measures on different oral health care needs is unclear. This study aimed to estimate the effect of COVID-19 mitigation measures on different types of oral health care utilization needs and explore the heterogeneity of such effects in different countries by using real-time Internet search data.

Methods: Data were obtained from Google Trends and other public databases.

Effects of early preventive dental visits and its associations with dental caries experience: a cross-sectional study.

Objectives: Limited information is known about preventive dental visits (PDVs) before seven years of age among children in China. This study aimed to examine the early PDV rate, identify the impact of PDV on dental caries and untreated dental caries, and explore the factors related to PDV among Chinese sampled children under seven years old.

Methods: A cross-sectional survey was conducted in five selected primary health care facilities in Chengdu, China, from May to August 2021.

Association between using social media WeChat and depressive symptoms among middle-aged and older people: findings from a national survey.

Objectives: We aimed to assess the characteristics and health status of a study sample using social media WeChat and to identify the association between social media usage and depressive symptoms among people aged 45 and older in China.

Methods: Data were drawn from the China Health and Retirement Longitudinal Study (CHARLS). Depressive symptoms were measured by the 10-item form of the Center for Epidemiologic Studies Depression Scale (CES-D-10).

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease.

The pro-inflammatory activation of microglia is a hallmark of Alzheimer's disease (AD), and this process involves a switch from oxidative phosphorylation (OXPHOS) toward glycolysis. Here, we show how a positive feedback loop in microglia drives AD pathogenesis, and we demonstrate that inhibiting this cycle in microglia can ameliorate Aβ burden and cognitive deficits in an AD mouse model (5XFAD). After first detecting elevated histone lactylation in brain samples from both 5XFAD mice and individuals with AD, we observed that H4K12la levels are elevated in Aβ plaque-adjacent microglia.

Evaluation of therapeutic effect and health economics of general anesthesia and routine outpatient dental treatment in children with severe early child caries.

Objectives: To evaluate the efficacy and health economics of the comprehensive therapy for the children with severe early child caries (S-ECC) under dental general anesthesia (DGA) and conventional outpatient treatment to provide references for dentists and parents in the choice of clinical treatment.

Methods: A retrospective cohort study was conducted on S-ECC children aged 36-71 months and who received dental treatment under general anesthesia or routine outpatient situation. The filled tooth survival rate, treatment cost, and cost-filled tooth survival time of the two groups were compared, and the curative effect and health economics was evaluated.

Astrocytes in depression and Alzheimer's disease.

Astrocytes are an abundant subgroup of cells in the central nervous system (CNS) that play a critical role in controlling neuronal circuits involved in emotion, learning, and memory. In clinical cases, multiple chronic brain diseases may cause psychosocial and cognitive impairment, such as depression and Alzheimer's disease (AD). For years, complex pathological conditions driven by depression and AD have been widely perceived to contribute to a high risk of disability, resulting in gradual loss of self-care ability, lower life qualities, and vast burden on human society.

Edentulism and select chronic diseases among adults aged ≥45 years in China, 2011-2018: A longitudinal study.

Objectives: Information on the association between edentulism and chronic medical conditions in developing countries is lacking. We investigated such information among adults aged ≥45 years in China.

Methods: A national longitudinal data set from the China Health and Retirement Longitudinal Study (CHARLS) 2011-2018 was analysed.

Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury.

Stem cell therapy is promising for neural repair in devastating traumatic brain injury (TBI). However, the low survival and differentiation rates of transplanted stem cells are main obstacles to efficient stem cell therapy in TBI. Stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 are key factors that regulate the survival, recruitment, and differentiation of stem cells.

[Routine Epidemic Prevention and Control and Treatment Process Reengineering of Outpatient Dental Care].

The coronavirus disease 2019 (COVID-19) pandemic is the most severe global public health emergency in over a hundred years. We have collected and organized prevention and control information from China and other counties and used it as an important reference for designing routine epidemic prevention and control measures and treatment process reengineering of outpatient dental services. Suggestions are made in the following aspects: standard precaution is adopted for all patients based on situational risk assessment conducted by the medical staffs; transmission-based precautions are adopted in addition while caring for patients who are suspected of or have been confirmed of having infectious diseases, in which scenario, standard precautions may not be enough; regarding clinical services, the triage process should be further improved, clinical service delivery areas should be redesigned to maximize safe distances, minimally invasive dentistry procedures should be prioritized for treatment, and postponement of treatment should be recommended appropriately; infection prevention and control guidelines should be regularly updated and relevant trainings provided to the medical staffs accordingly; COVID-19 incidents associated with delivery of dental care should be documented and evaluated; it is also important to communicate with Chinese and international colleagues and stress research and professional training.

Re-expression of DIRAS3 and p53 induces apoptosis and impaired autophagy in head and neck squamous cell carcinoma.

Background: p53 and DIRAS3 are tumor suppressors that are frequently silenced in tumors. In this study, we sought to determine whether the concurrent re-expression of p53 and DIRAS3 could effectively induce head and neck squamous cell carcinoma (HNSCC) cell death.

Methods: CAL-27 and SCC-25 cells were treated with Ad-DIRAS3 and rAd-p53 to induce re-expression of DIRAS3 and p53 respectively.

The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury.

Background: Traumatic brain injury (TBI) is a common neurotrauma leading to brain dysfunction and death. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) hold promise in the treatment of TBI. However, their efficacy is modest due to low survival and differentiation under the harsh microenvironment of the injured brain.

Corrigendum: HDAC1 Silence Promotes Neuroprotective Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in a Mouse Model of Traumatic Brain Injury PI3K/AKT Pathway.

[This corrects the article DOI: 10.3389/fncel.2018.