Predicting progression of STEC-HUS: Use of Shiga toxin subtype and routine laboratory screening.

Background: Hemolytic uremic syndrome (HUS) is life-threatening sequelae of Shiga toxin producing Escherichia coli (STEC) enteric infection. To address ambiguity in medical literature, we aimed to identify which STEC toxin profiles and clinical variables were at highest risk of HUS progression to inform evidence-based screening guidelines.

Methods: This was a 5-year retrospective study of children aged <18 years with E.