Publications by authors named "Xing Liao"

Leaf mass per area (LMA) and photosynthetic rate (A) explain fast-slow growth strategies in worldwide leaf economic spectrum. Nitrogen (N) promotes A and rapid growth; while LMA response to N supply in a genotype specific manner. Structural traits affect the relationship between LMA and A, and we hypothesized that N supply would affect structural traits and thus the coupling between LMA and A.

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mRNA vaccine has become a promising technology platform for rabies prevention. This study explores the roles of different structural domains of rabies virus glycoprotein (RABV-G) and heterologous prime-boost strategies for enhanced immune responses and protection. The results suggested that mRNA vaccines encoding full-length RABV-G (RABV-Full) and RABV-R333Q induced strong immune responses and provided full protection against rabies, while mRNA vaccines encoding ectodomain/transmembrane domain (RABV-TE) and ectodomain (RABV-E) were less effective.

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Nonalcoholic fatty liver disease (NAFLD) occurs when too much fat builds up in the liver. As a growing worldwide epidemic, NAFLD is strongly linked with multiple metabolic diseases including obesity, insulin resistance, and dyslipidemia. However, very few effective treatments are currently available.

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Organophosphate esters (OPEs) can disrupt thyroid function, but the association between OPEs and thyroid function is limited. In this study, the association between OPEs and thyroid hormones (THs) was studied. The study population was comprised of two groups: early-pregnancy and mid-pregnancy.

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Evidence mapping was used to systematically analyze the clinical research evidence of oral Chinese patent medicines in the treatment of intracerebral hemorrhage(ICH), thus revealing the distribution and quality of evidence in this field. The relevant articles were retrieved from CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, Cochrane Library, and Web of Science from inception to July 5, 2024. The distribution characteristics of evidence were presented numerically and graphically.

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Background: Tension-type headache (TTH) is the most common type of headache and the second most common health-related complaint among children and adults. Traditional Chinese medicine (TCM) offers unique therapeutic benefits in treating TTH. However, the lack of standardized evidence-such as inconsistencies in outcome selection and reporting in clinical studies, a lack of consensus on outcomes and measures, high risks of selective reporting bias, and missing data-has limited the development of robust evidence supporting the efficacy of TCM in treating TTH.

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Large language models (LLMs) have the potential to enhance evidence synthesis efficiency and accuracy. This study assessed LLM-only and LLM-assisted methods in data extraction and risk of bias assessment for 107 trials on complementary medicine. Moonshot-v1-128k and Claude-3.

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Objective: To explore patients' perceptions and attitudes towards patient guidelines (PGs) and to identify specific factors related to PG content, design, presentation, and management that may influence patients' use or adoption of PGs.

Methods: An exploratory sequential mixed-methods design was employed. Initial semi-structured interviews were conducted with a diverse group of individuals, including people with diabetes or oncology, and clinicians.

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This study aims to establish the standard items for conducting and reporting rapid review(RR) in traditional Chinese medicine(TCM) and promote the RR transparency in TCM. First, the basic standard items of conducting and reporting RR were reviewed, on the basis of which the basic RR implementation methods and steps were summarized. The initial item pool of RR implementation and reporting standards in TCM was established with the Delphi method.

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This study aims to establish the implementation standard of health technology assessment(HTA) in traditional Chinese medicine(TCM), so as to promote the scientific and standardized implementation and application of HTA in TCM for high-quality decision-making. Based on the published HTA method guidelines, the literature analysis and expert consensus method were used to establish the implementation standard of HTA in TCM with implementation steps, assessment domains, and reporting checklists as the main content. A total of 41 HTA guidelines were included.

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Life is a dynamic and systematic whole, with organs interacting with each other. Traditional Chinese medicine(TCM) discusses the interaction between human tissue and organs through the Zangfu relations, while modern biological medicine clarifies physiological and pathological relationships through "organ crosstalk". From the perspective of "organ crosstalk", this article discussed the five classical Zangfu relations(lungs and large intestine, heart and small intestine, spleen and stomach, liver and gallbladder, and kidney and bladder) in TCM and their extension.

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Background: This study aimed to synthesize the recommendations for prediction models in cardiovascular clinical practice guidelines (CPGs) and assess the methodological quality of the relevant primary modeling studies.

Methods: We performed a systematic literature search of all available cardiovascular CPGs published between 2018 and 2023 that presented specific recommendations (whether in support or non-support) for at least one multivariable clinical prediction model. For the guideline-recommended models, the assessment of the methodological quality of their primary modeling studies was conducted using the Prediction model Risk Of Bias ASsessment Tool (PROBAST).

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Article Synopsis
  • - This study evaluated the cost-effectiveness of Shaoma Zhijing Granules compared to two other treatments for tic disorder in children, analyzing data from 17 articles.
  • - The results showed that while Shaoma Zhijing Granules had a total cost of CNY 4,410 and a clinical effectiveness rate of 77.53%, Jiuwei Xifeng Granules was more effective at a higher cost (CNY 5,192.70), and Changma Xifeng Tablets offered more benefits at a lower cost (CNY 1,282.50).
  • - Ultimately, the analysis determined that Shaoma Zhijing Granules did not provide a cost-effective advantage compared to the other treatments assessed. *
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Purpose: Heterologous immunization using different vaccine platforms has been demonstrated as an efficient strategy to enhance antigen-specific immune responses. In this study, we performed a head-to-head comparison of both humoral and cellular immune response induced by different prime-boost immunization regimens of mRNA vaccine and adjuvanted protein subunit vaccine against varicella-zoster virus (VZV) in middle-aged mice, aiming to get a better understanding of the influence of vaccination schedule on immune response.

Methods: VZV glycoprotein (gE) mRNA was synthesized and encapsulated into SM-102-based lipid nanoparticles (LNPs).

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This study aimed to investigate whether dexmedetomidine provides survival benefit in critically ill patients with sepsis-induced coagulopathy (SIC). Patients with sepsis-induced coagulopathy admitted to the ICU were identified from the Medical Information Marketplace for Intensive Care (MIMIC)-IV database. They were divided into two groups: patients who started dexmedetomidine within 48 h of ICU admission and lasted for more than 4 h and patients who did not receive dexmedetomidine as a control group.

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Ethnopharmacological Relevance: (), a genus of ascomycete fungi, has been widedly used in China as a dietary supplement or natural remedy and intensively studied in various disease models with its immunomodulatory potentials. It is a rich source of various bioactive compounds and used for treating end-stage renal disease. This systematic review with clinical evidence aimed to highlight the efficacy and safety of as an adjuvant treatment for patients undergoing dialysis.

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Article Synopsis
  • The study aimed to explore the link between changes in serum ferritin levels during pregnancy and the occurrence of chorioamnionitis and neonatal sepsis among a large group of pregnant women in Fujian, China.
  • The research included data from 8506 clinical records, finding a significant difference in serum ferritin levels between those with confirmed chorioamnionitis and those without, while no significant difference was noted for neonatal sepsis.
  • The results suggest that while alterations in serum ferritin may serve as a predictor for chorioamnionitis during pregnancy, they do not effectively indicate the risk of neonatal sepsis.
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Background: The profiles of bile acids (BAs) in patients with gallstone disease (GSD) have been found to be altered markedly though in an inconsistent pattern. This study aims to characterize the variation of the BA profiles in GSD patients, thereby to discover the potential metabolite biomarkers for earlier detection of GSD.

Methods: Literature search of eight electronic database in both English and Chinese was completed on May 11, 2023.

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Improving the nutrient content of red soils in southern China is a priority for efficient rice production there. To assess the effectiveness of oilseed rape as green manure for the improvement of soil phosphorus nutrient supply and rice yield in red soil areas, a long-term field plot experiment was conducted comparing two species of rape, (BN) and (BJ). The effects of returning oilseed rape on soil phosphorus availability, phosphorus absorption, and yield of subsequent rice under rice-green manure rotation mode were analyzed, using data from the seasons of 2020 to 2021.

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Article Synopsis
  • - A scoping review was conducted to analyze existing studies on the effectiveness of acupuncture for infertility, particularly its role in achieving natural conception, focusing on data from multiple databases up to August 2023.
  • - Out of 310 articles reviewed, most studies centered on female infertility, particularly related to conditions like polycystic ovary syndrome and ovulation disorders, with some addressing male infertility.
  • - The meta-analysis indicated that acupuncture showed better results for infertility than the hormone human chorionic gonadotropin (HCG), both alone and in combination, highlighting acupuncture's potential as a treatment option.
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Objective: To assess the quality of Clinical practice guidelines (CPGs) in the context of diabetic kidney disease (DKD) and determine whether any factors affect the quality.

Methods: We searched eight databases along with five international and national organizations to develop or archive guidelines from their inception to July 2023, with an additional search of medlive.cn.

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To explore the effect of targeted second-generation sequencing technique to guide clinical diagnosis and medication on the therapeutic effect and prognosis of respiratory tract infection (RTI) in children. During January 2021 to June 2022, 320 children with RTI cured were selected in our hospital as the object of this retrospective study. The control group accepted empirical broad-spectrum antibacterial therapy and the observation group accepted targeted second-generation sequencing technique to guide diagnosis and medication.

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Article Synopsis
  • * The research identified 19 types of Chinese patent medicines, highlighting that 13 were significantly discussed in 131 articles, with popular ones being Shenqi Jiangtang Capsules, Jinlida Granules, and Xiaoke Pills, measuring various health outcomes like blood glucose and pancreatic function.
  • * The analysis indicated a need for improved research quality, noting most studies lacked proper methodological rigor and underrepresented the unique aspects of traditional Chinese medicine, particularly in evaluating TCM-specific symptoms and patient quality of life.
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Covalent organic frameworks (COFs), with the features of flexible structure regulation and easy introduction of functional groups, have aroused broad interest in the field of photocatalysis. However, due to the low light absorption intensity, low photoelectron conversion efficiency, and lack of suitable active sites, it remains a great challenge to achieve efficient photocatalytic aerobic oxidation reactions. Herein, based on reticular chemistry, we rationally designed a series of three-motif molecular junction type COFs, which formed dual photosensitizer coupled redox molecular junctions containing multifunctional COF photocatalysts.

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