A Submicrosecond-Response Ultrafast Microwave Ranging Method Based on Optically Generated Frequency-Modulated Pulses.

An ultrafast microwave ranging method based on optically generated frequency-modulated microwave pulses is proposed in this study. The theoretical analysis demonstrated that nanosecond-scale linear frequency modulation microwave pulse can be obtained by femtosecond laser interference under the condition of unbalanced dispersion, which can be used to achieve a high temporal resolution of the displacement change in the measurement by the principle of frequency modulation continuous wave (FMCW) radar. The proof-of-principle experiment successfully measured the displacement change with an error of 2.

Elucidating the anticancer potential of dendrobine in renal cell carcinoma treatment.

Renal cell carcinoma (RCC) is the predominant form of kidney cancer. Despite the significant improvements in survival rates for advanced RCC patients due to targeted therapy and immunotherapy, challenges such as drug resistance and severe adverse reactions continue to hinder effective management. Therefore, there is an urgent need to identify new therapeutic agents for RCC.

A forecasting tool for optimized emission control strategies to achieve short-term air quality attainment.

Optimizing an emergency air pollution control strategy for haze events presents a significant challenge due to the extensive computational demands required to quantify the complex nonlinearity associated with controls on diverse air pollutants and regional sources. In this study, we developed a forecasting tool for emergency air pollution control strategies based on a predictive response surface model that quantifies PM responses to emission changes from different pollutants and regions. This tool is equipped to assess the effectiveness of emergency control measures corresponding to various air pollution alerts and to formulate an optimized control strategy aimed at specific PM targets.

A Physically Constrained Deep-Learning Fusion Method for Estimating Surface NO Concentration from Satellite and Ground Monitors.

Accurate estimation of atmospheric chemical concentrations from multiple observations is crucial for assessing the health effects of air pollution. However, existing methods are limited by imbalanced samples from observations. Here, we introduce a novel deep-learning model-measurement fusion method (DeepMMF) constrained by physical laws inferred from a chemical transport model (CTM) to estimate NO concentrations over the Continental United States (CONUS).

Can early gut microbiota screening reduce the incidence of cognitive impairment? A Mendelian randomization study.

Gastrointestinal symptoms are now detected early in the clinical course of many dementia patients, and studies of the microbiome-gut-brain axis have confirmed bidirectional interactions between the gut and the brain. However, the causal relationship between gut microbiota and cognitive impairment has not been fully established. Therefore, this study conducted a bidirectional Mendelian randomization study to elucidate the potential causal relationship of gut microbiota to cognitive impairment.

The Side-Release Method Measures the High-Pressure Sound Velocity of Iron Using Line-Spatially Resolved DISAR.

The study of high-pressure sound velocity is an important part of shock wave physics, and the study of ultra-high pressure sound velocity of iron is of great significance to many research fields such as geophysics, solid state physics, and crystallography. At present, the measurement of sound velocity is usually carried out by the catch-up sparse wave method and windowed VISAR technology, which is complex in structure and not highly adaptable. In particular, for the ultra-high pressure sonic velocity measurement of metals, it is limited by the loading platform and window materials and cannot realize the high temperature and high-pressure environment of the earth's inner core.

TRIB3 knockdown increases the sensitivity of clear cell renal cell carcinoma to sunitinib by inducing ferroptosis.

Sunitinib resistance presents a significant challenge in the treatment of clear cell renal cell carcinoma (ccRCC). The role of TRIB3, a newly identified oncogene, in tumor drug resistance has been widely studied. However, the mechanism by which TRIB3 contributes to sunitinib resistance in ccRCC has not been previously explored.

An estimation of future county-level cement production and associated air pollutant emissions in China through artificial neural networks.

Cement production and its air pollutant and carbon dioxides (CO) emissions in China will be relocated greatly as a joint effect of diverse development of industrial economy and implementation of environmental policies for different regions. The future pathway and spatial pattern of emissions are important for policy making of air quality improvement and CO emission abatement, as well as coordinating regional development. In this study, we developed an artificial neural network (ANN) model to predict cement production at the county level and to calculate the associated emissions of air pollutants and CO at the county level till 2060.

Unveiling the health impacts of air pollution transport in China.

The transport of atmospheric pollutants plays a pivotal role in regional air pollution, highlighting critical concerns over the unequal health outcomes that arise from such transport. While previous researches predominantly focused on key areas in the battle against air pollution, the intensification of control measures necessitates a national perspective to comprehend the health impacts due to pollution transport. Our study establishes an integrated assessment framework that combine an emission-concentration response surface model with a health impact evaluation model to analyse the nationwide health impacts of PM and O pollution transport across China's 31 provinces.

AUY922 improves sensitivity to sunitinib in clear cell renal cell carcinoma based on network pharmacology and in vitro experiments.

Clear Cell Renal Cell Carcinoma (ccRCC), the most prevalent form of renal cell carcinoma (RCC), poses a significant threat to human health due to its rising morbidity and mortality rates. Sunitinib, a pivotal targeted drug for the treatment of ccRCC, presents a significant challenge due to the high susceptibility of ccRCC to resistance. HSP90 inhibitor AUY922 has demonstrated anti-tumor activity in a range of cancer types.

Peptidomic analysis reveals novel peptide PDLC promotes cell proliferation in hepatocellular carcinoma via Ras/Raf/MEK/ERK pathway.

Hepatocellular carcinoma (HCC) still presents poor prognosis with low overall survival rates and limited therapeutic options available. Recently, attention has been drawn to peptidomic analysis, an emerging field of proteomics for the exploration of new potential peptide drugs for the treatment of various diseases. However, research on the potential function of HCC peptides is lacking.

Air Quality, Health, and Equity Benefits of Carbon Neutrality and Clean Air Pathways in China.

In the pursuit of carbon neutrality, China's 2060 targets have been largely anchored in reducing greenhouse gas emissions, with less emphasis on the consequential benefits for air quality and public health. This study pivots to this critical nexus, exploring how China's carbon neutrality aligns with the World Health Organization's air quality guidelines (WHO AQG) regarding fine particulate matter (PM) exposure. Coupling a technology-rich integrated assessment model, an emission-concentration response surface model, and exposure and health assessment, we find that decarbonization reduces sulfur dioxide (SO), nitrogen oxides (NO), and PM emissions by more than 90%; reduces nonmethane volatile organic compounds (NMVOCs) by more than 50%; and simultaneously reduces the disparities across regions.

The Global Incident Gastrointestinal Cancers Attributable to Suboptimal Diets From 1990 to 2018.

Background & Aims: The contribution of suboptimal diets to gastrointestinal (GI) cancer incidence globally remains unquantified, and we aimed to evaluate it.

Methods: Comprehensive meta-analyses and rigorous evidence-grading assessment identified the associations between suboptimal diets and 6 GI cancers and their subtypes. A comparative risk assessment model was used to estimate the proportional attributable burden and attributable rate of GI cancers to suboptimal diets by using the corroborative association estimates.

Health-Oriented Emission Control Strategy of Energy Utilization and Its Co-CO Benefits: A Case Study of the Yangtze River Delta, China.

Reducing air pollutants and CO emissions from energy utilization is crucial for achieving the dual objectives of clean air and carbon neutrality in China. Thus, an optimized health-oriented strategy is urgently needed. Herein, by coupling a CO and air pollutants emission inventory with response surface models for PM-associated mortality, we shed light on the effectiveness of protecting human health and co-CO benefit from reducing fuel-related emissions and generate a health-oriented strategy for the Yangtze River Delta (YRD).

REEP4 as Potential Biomarker Associated with Predictive Prognosis and Immune Response in Kidney Clear Cell Carcinoma.

Kidney clear cell carcinoma (KIRC) commonly presents with metastases upon diagnosis, highlighting the critical need to identify more precise biomarkers for early detection, intervention, and personalized treatment. Although The REEP family has been investigated in cancer development, the specific relationship between REEP4 and cancer remains unclear. In our study, we employed bioinformatics analysis and conducted fundamental experiments to evaluate the potential of REEP4 as a biomarker for predicting the prognosis and therapeutic efficacy of KIRC.

Spatially and Temporally Differentiated NO and VOCs Emission Abatement Could Effectively Gain O-Related Health Benefits.

The increasing level of O pollution in China significantly exacerbates the long-term O health damage, and an optimized health-oriented strategy for NO and VOCs emission abatement is needed. Here, we developed an integrated evaluation and optimization system for the O control strategy by merging a response surface model for the O-related mortality and an optimization module. Applying this system to the Yangtze River Delta (YRD), we evaluated driving factors for mortality changes from 2013 to 2017, quantified spatial and temporal O-related mortality responses to precursor emission abatement, and optimized a health-oriented control strategy.

Electrospun medicated gelatin/polycaprolactone Janus fibers for photothermal-chem combined therapy of liver cancer.

Liver cancer is a common cancer in the world, and core-shell nanoparticles as a commonly used combination therapy for local tumor ablation, have many shortcomings. In this study, photothermal Janus nanofibers were prepared using a electrospinning technology for tumor treatment, and the products were characterized and in vitro photothermal performance investigated. The micromorphology analysis showed that the photothermic agent CuS and electrospun fibers (loaded with CuS and anticancer drug dihydromyricetin) were successfully prepared, with diameters of 11.

Rapid hydrolysis of NO at High Ionic Strengths of Deliquesced Aerosol Particles.

Nitrogen dioxide (NO) hydrolysis in deliquesced aerosol particles forms nitrous acid and nitrate and thus impacts air quality, climate, and the nitrogen cycle. Traditionally, it is considered to proceed far too slowly in the atmosphere. However, the significance of this process is highly uncertain because kinetic studies have only been made in dilute aqueous solutions but not under high ionic strength conditions of the aerosol particles.

A probe into the acid deposition mitigation path in China over the last four decades and beyond.

China currently has the highest acid deposition globally, yet research on its status, impacts, causes and controls is lacking. Here, we compiled data and calculated critical loads regarding acid deposition. The results showed that the abatement measures in China have achieved a sharp decline in the emissions of acidifying pollutants and a continuous recovery of precipitation pH, despite the drastic growth in the economy and energy consumption.

SERPINE2 promotes liver cancer metastasis by inhibiting c-Cbl-mediated EGFR ubiquitination and degradation.

Background: Liver cancer is a malignancy with high morbidity and mortality rates. Serpin family E member 2 (SERPINE2) has been reported to play a key role in the metastasis of many tumors. In this study, we aimed to investigate the potential mechanism of SERPINE2 in liver cancer metastasis.

Unveiling the breadmaking transformation: Structural and functional insights into Arabinoxylan.

To understand the changes in arabinoxylan (AX) during breadmaking, multi-step enzyme digestion was conducted to re-extract arabinoxylan (AX-B) from AX-fortified bread. Their structural changes were compared using HPSEC, HPAEC, FT-IR, methylation analysis, and H NMR analysis; their properties changes in terms of enzymatic inhibition activities and in vitro fermentability against gut microbiota were also compared. Results showed that AX-B contained a higher portion of covalently linked protein while the molecular weight was reduced significantly after breadmaking process (from 677.

Effect of Future Climate Change on Stratosphere-to-Troposphere-Exchange Driven Ozone in the Northern Hemisphere.

Future estimates of atmospheric pollutant concentrations serve as critical information for policy makers to formulate current policy indicators to achieve future targets. Tropospheric burden of O is modulated not only by anthropogenic and natural precursor emissions, but also by the downward transport of O associated with stratosphere to troposphere exchange (STE). Hence changes in the estimates of STE and its contributions are key to understand the nature and intensity of future ground level O concentrations.