Risk factors for seizure reoccurrence after withdrawal from antiepileptic drugs in individuals who have been seizure-free for over 2 years.

Purpose: To observe risk factors for recurrence after withdrawal from antiepileptic drugs.

Methods: We assessed 1282 patients with a definite diagnosis of epilepsy.

Results: In total, 292 patients between 14 and 80 years of age were grouped according to risk factors for recurrence.

eEF-2 Phosphorylation Down-Regulates P-Glycoprotein Over-Expression in Rat Brain Microvessel Endothelial Cells.

Objective: We investigated whether glutamate, NMDA receptors, and eukaryote elongation factor-2 kinase (eEF-2K)/eEF-2 regulate P-glycoprotein expression, and the effects of the eEF-2K inhibitor NH125 on the expression of P-glycoprotein in rat brain microvessel endothelial cells (RBMECs).

Methods: Cortex was obtained from newborn Wistar rat brains. After surface vessels and meninges were removed, the pellet containing microvessels was resuspended and incubated at 37°C in culture medium.

Enhanced brain delivery of lamotrigine with Pluronic(®) P123-based nanocarrier.

Background: P-glycoprotein (P-gp) mediated drug efflux across the blood-brain barrier (BBB) is an important mechanism underlying poor brain penetration of certain antiepileptic drugs (AEDs). Nanomaterials, as drug carriers, can overcome P-gp activity and improve the targeted delivery of AEDs. However, their applications in the delivery of AEDs have not been adequately investigated.

Tenidap is neuroprotective in a pilocarpine rat model of temporal lobe epilepsy.

Background: Tenidap is a liposoluble non-steroidal anti-inflammatory drug that is easily distributed in the central nervous system and also inhibits the production and activity of cyclooxygenase-2 (COX-2) and cytokines in vitro. This study aimed to evaluate the neuroprotective effect of tenidap in a pilocarpine rat model of temporal lobe epilepsy (TLE).

Methods: Tenidap was administered daily at 10 mg/kg for 10 days following pilocarpine-induced status epilepticus (SE) in male Wistar rats after which prolonged generalized seizures resulted in TLE.

Evaluation of clinical aspects and quality of life as risk factors for depression in patients with epilepsy.

The purpose of this study was to investigate clinical aspects and quality of life (QOL) as risk factors for depression in patients with epilepsy. One hundred and forty outpatients with a diagnosis of epilepsy who were attending our epilepsy center participated. Patients anonymously filled out a questionnaire with clinical data related to epilepsy.

Treatment of epilepsy in adults: expert opinion in China.

Objective: The goal of this study was to survey a group of epileptologists in China regarding the treatment of adult epilepsy.

Methods: A questionnaire on treatment of adult epilepsy was sent to a group of opinion leaders in the field of epilepsy.

Results: For initial monotherapy for idiopathic generalized epilepsy (IGE), valproate was rated as the treatment of choice.

[Clinically anatomic study on the relation between the form of pleural cupula and its surrounding commonly-used acupoints].

Objective: To explore the relation of the form of pleural cupula of the normal adult with safety of acupuncture at commonly-used acupoints around the pleural cupula.

Methods: The safe depth for the commonly-used acupoints around the pleural cupula and the relation with the form of pleural cupula were investigated in 46 adult corpses with small Kirschner wire location and arrangement dissection.

Results: The width of the pleural cupula projection equal to clavicle medial 1/3 accounted for 32.