Quantitative assessment of left ventricular function by left ventricular pressure-strain loop in patients with end-stage renal disease.

A new and non-invasive technology of left ventricular pressure-strain loop (LV-PSL) has recently been used to provide information on myocardial work (MW) and identify subtle modifications in cardiac function. This study aimed to use LV-PSL for early identification of changes in LV structure and MW in patients with end-stage renal disease (ESRD). Methods： Seventy-two patients with ESRD were divided into two groups based on undergoing maintenance hemodialysis (MHD), namely the dialysis group (ESRD-D group) and non-dialysis group (ESRD-ND group).

The attenuated Pseudorabies virus vaccine Bartha K61 induces a weak cellular immunity: implications for the development of PRV-vectored vaccines.

Pseudorabies virus (PRV), causing Aujeszky's disease in swine, has important economic impact on the pig industry in China and even poses a threat to public health. Although this disease has been controlled by vaccination with PRV live attenuated vaccines (LAVs), the potency of PRV LAVs in inducing cellular immunity has not been well characterized. In this study, using PRV Bartha K61 strain (BK61), the most-used PRV LAVs, as a model, we re-examined the cellular immune response elicited by the BK61 in mice and pigs by multicolor flow cytometry.

Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies.

Increasing evidence points toward an essential role for complement activation in the pathogenesis of diabetic kidney disease (DKD). However, the precise molecular mechanisms remain unclear, and the pathway predominantly contributing to complement activation in DKD is of particular interest. In this study, the glomerular proteome, especially the profiles of the complement proteins, was analyzed in kidney biopsies from 40 DKD patients and 10 normal controls using laser microdissection-assisted liquid chromatography-tandem mass spectrometry (LMD-LC-MS/MS).

Intramolecular Repulsive Interactions Enable High Efficiency of NIR-II Aggregation-Induced Emission Luminogens for High-Contrast Glioblastoma Imaging.

Strategies to acquire high-efficiency luminogens that emit in the second near-infrared (NIR-II, 1000-1700 nm) range are still rare due to the impediment of the energy gap law. Herein, a feasible strategy is pioneered by installing large-volume encumbrances in a confined space to intensify the repulsive interactions arising from overlapping electron densities. The experimental results, including smaller coordinate displacement, reduced reorganization energy, and suppressed internal conversion, demonstrate that the repulsive interactions assist in the inhibition of radiationless deactivation.

β-Stereoselective Kdo -glycosylation by a (-Tol)SO/TfO preactivation strategy.

There is very little research on the synthesis of β-3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) -glycosides, which restricted their widespread application. Herein, a convenient and efficient approach to synthesize β-Kdo -glycosides was developed based on a TfO/(-Tol)SO preactivation strategy using bench stable peracetylated Kdo thioglycoside as a donor a thermodynamic S1-like mechanism.

Supramolecular ionogels enable highly efficient electrochromism.

Ionogels are a promising solution to improve the functionality of electrochromic devices (ECDs) by solving issues related to traditional liquid electrolytes, such as volatility, toxicity, and leakage. However, manufacturing ionogels is complicated as it often involves cross-linking polymerization or chemical sol-gel processes, requiring large amounts of inorganic or polymeric gelators. This results in low ionic conductivity and poor ECD performance.

Excitation-mode-selective emission through multiexcitonic states in a double perovskite single crystal.

Low-dimensional lead-free metal halide perovskites are highly attractive for cutting-edge optoelectronic applications. Herein, we report a class of scandium-based double perovskite crystals comprising antimony dopants that can generate multiexcitonic emissions in the ultraviolet, blue, and yellow spectral regions. Owing to the zero-dimensional nature of the crystal lattice that minimizes energy crosstalk, different excitonic states in the crystals can be selectively excited by ultraviolet light, X-ray irradiation, and mechanical action, enabling dynamic control of steady/transient-state spectral features by modulating the excitation modes.

Robust ferromagnetism in wafer-scale FeGaTe above room-temperature.

The discovery of ferromagnetism in van der Waals (vdW) materials has enriched the understanding of two-dimensional (2D) magnetic orders and opened new avenues for fundamental physics research and next generation spintronics. However, achieving ferromagnetic order at room temperature, along with strong perpendicular magnetic anisotropy, remains a significant challenge. In this work, we report wafer-scale growth of vdW ferromagnet FeGaTe using molecular beam epitaxy.

Robotic-assisted Kasai portoenterostomy for child biliary atresia.

Background: The Kasai procedure (KPE) is an important treatment for biliary atresia (BA), the most common cause of neonatal obstructive jaundice.

Aim: To investigate the efficacy of robotic-assisted Kasai portoenterostomy (RAKPE) in patients with BA.

Methods: Clinical data of 10 patients with BA who underwent RAKPE at the Seventh Medical Center of the People's Liberation Army General Hospital between December 2018 and December 2021 were retrospectively analyzed.

Host lipid metabolism influences the variation in resistance of Pekin ducks to duck hepatitis A virus genotype 3.

Duck viral hepatitis (DVH) is a common and serious acute infectious disease that has a significantly impact on the duck farming industry. Duck hepatitis A virus type 3 (DHAV-3) is the major causative agent of DVH in East Asia. Host factor indicators of resistance to DHAV-3 in Pekin ducks were investigated using resistant (Z7R) and susceptible (Z7S) duck lines.

Strongly Anchored Dion-Jacobson Perovskite for Efficient Blue Light-Emitting Diodes.

Dion-Jacobson (DJ) perovskites are promising alternatives for Ruddlesden-Popper (RP) perovskites to fabricate blue perovskite light-emitting diodes (PeLEDs) due to their favorable structural and charge properties. However, the relatively weak hydrogen bond between the bridging diammonium group and perovskite poses huge challenges for regulating crystallization and defect density, leading to an undesirable film quality and device performance. Herein, we report the successful optimization of DJ perovskite films by introducing a new type of cesium octafluoroadipate (CsOFAA) precursor, which could strongly anchor the perovskite through coordination bonds and halogen-halogen bonds.

Associations of C-reactive protein to lymphocyte ratio and metabolic-dysfunction-associated steatotic liver disease: evidence from NHANES 2017-2018.

Background: This study aimed to investigate the association between Metabolic-dysfunction-associated steatotic liver disease(MASLD)and C-reactive protein/lymphocyte ratio (CLR).

Methods: MASLD was defined as a Controlled Attenuation Parameter (CAP ≥ 274dB/m) and CLR = C-reactive protein/lymphocyte. A multifactor linear regression model was used to test the relationship between MASLD and CLR.

Research progress on the mechanism of hyperuricemic nephropathy based on multi-omics technique: A review.

Hyperuricemic nephropathy is a metabolic disease in which renal uric acid deposition and excretion are impaired due to elevated levels of uric acid in the blood, leading to impaired renal tubule function and chronic renal disease. Hyperuricemic nephropathy is one of the important complications of hyperuricemia, which seriously affects the quality of life and prognosis of patients. The pathogenesis of hyperuricemic nephropathy involves a variety of factors, including: amino acid metabolism disorder, energy metabolism abnormality, increased nucleotide metabolism, lipid metabolism disorder and bile acid metabolism imbalance, REDOX process disorder, cell cycle and apoptosis imbalance, signal transduction and inflammatory response enhancement, and intestinal flora imbalance.

Unveiling the global dynamics of dissolved organic carbon in aquatic ecosystems: Climatic and anthropogenic impact, and future predictions.

Dissolved organic carbon (DOC) and its biodegradability (BDOC%) in aquatic ecosystems significantly impact the global carbon cycle, varying greatly across rivers, lakes, and estuaries due to environmental and anthropogenic factors. However, a thorough understanding of these variations is still lacking. This study investigated the interactions between climate, hydrology, physiography, soil, land cover, and human activity on DOC dynamics in rivers, lakes, and estuaries.

Thiamethoxam-Loaded Ethyl Cellulose Microspheres for Extending the Efficacy Duration and Reducing the Toxicity on the Growth of Maize ( L.).

Thiamethoxam has been widely used in agriculture due to its excellent insecticidal activity. However, thiamethoxam is prone to loss during practical applications, especially in soil application, which seriously reduces its performance. In this work, thiamethoxam is loaded in ethyl cellulose microspheres to solve this issue, and the thiamethoxam-loaded ethyl cellulose microspheres (thiamethoxam/EC) are facilely and effectively fabricated by emulsified solvent volatilization.

Fatty acid traits mediate the effects of uric acid on cancers: a Mendelian randomization study.

Introduction: Previous findings on the association between uric acid (UA) levels and cancer risk are conflicting. Moreover, the mechanisms underlying the interactions between UA levels, fatty acid traits, and cancer outcomes remain complex; it is still unclear whether elevated UA levels influence fatty acid traits and, thereby, contribute to an increased cancer risk. Therefore, we aimed to investigate the association between UA levels and cancer risk, with a specific focus on the potential mediating role of fatty acid traits.

Assessment of transglutaminase catalyzed cross-linking on the potential allergenicity and conformation of heterologous protein polymers.

Transglutaminase (TGase)-mediated cross-linking has gained significant attention due to its potential to reduce the allergenicity of food proteins. This study investigates the effects of TGase cross-linking on allergenicity and conformational modifications in a dual-protein system comprising soy protein isolate (SPI) and β-lactoglobulin (β-LG). The results showed that TGase cross-linking effectively decreased the allergenic potential of both SPI and β-LG, with a more pronounced reduction observed in the allergenicity of soy protein in the dual-protein system.

Implication of GPRASP2 in the Proliferation and Hair Cell-Forming of Cochlear Supporting Cells.

G protein-coupled receptor-associated sorting protein 2 (GPRASP2) has been identified as the causative gene for X-linked recessive syndromic hearing loss (SHL) in our previous study. However, the role of GPRASP2 in auditory function remains unclear. The present study demonstrated that Gprasp2 overexpression in mouse organoids promoted the proliferation of supporting cells (SCs), which was mainly mediated by the Hedgehog signalling pathway.

Clinicopathological characteristics of light chain proximal tubulopathy: a multicentre case series.

Aims: Light chain proximal tubulopathy (LCPT) is a rare complication of paraprotein-related diseases. We report a case series to present the clinicopathological characteristics and outcomes of LCPT.

Methods: A multicentre retrospective case series of 47 patients with LCPT, consisting of 36 crystalline, three non-crystalline, and eight mixed LCPTs, was studied between January 2007 and December 2023.

Gut mycobiome alterations and network interactions with the bacteriome in patients with atherosclerotic cardiovascular disease.

The connection between the gut mycobiome and atherosclerotic cardiovascular disease (ACVD) is largely uncharted. In our study, we compared the gut fungal communities of 214 ACVD patients with those of 171 healthy controls using shotgun metagenomic sequencing and examined their interactions with gut bacterial communities and network key taxa. The gut mycobiome composition in ACVD patients is significantly different, showing a rise in opportunistic pathogens like , , and , with and showing the most significant changes (Wilcoxon rank-sum test, < 0.

Machine Learning-Driven Methods for Nanobody Affinity Prediction.

Because of their high affinity, specificity, and environmental stability, nanobodies (Nbs) have continuously received attention from the field of biological research. However, it is tough work to obtain high-affinity Nbs using experimental methods. In the current study, 12 machine learning algorithms were compared in parallel to explore the potential patterns between Nb-ligand affinity and eight noncovalent interactions.

The Shu complex is an ATPase that regulates Rad51 filaments during homologous recombination in the DNA damage response.

Rad51 filaments are Rad51-coated single-stranded DNA and essential in homologous recombination (HR). The yeast Shu complex (Shu) is a conserved regulator of homologous recombination, working through its modulation on Rad51 filaments to direct HR-associated DNA damage response. However, the biochemical properties of Shu remain unclear, which hinders molecular insights into Shu's role in HR and the DNA damage response.