Publications by authors named "Xing Cen"
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by disturbance of pro-inflammatory and anti-inflammatory lymphocytes. Growing evidence shown that gut microbiota participated in the occurrence and development of SLE by affecting the differentiation and function of intestinal immune cells. The purpose of this study was to investigate the changes of gut microbiota in SLE and judge its associations with peripheral T lymphocytes.
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- The study investigated the relationship between long non-coding RNAs (lncRNAs) and regulatory T (Treg) cells in patients with systemic lupus erythematosus (SLE) to better understand potential treatment strategies.
- Researchers analyzed lncRNA expression profiles in the peripheral blood of nine active SLE patients compared to nine healthy control individuals, identifying 240 differentially expressed lncRNAs.
- Notable findings include specific lncRNAs positively and negatively correlating with Treg cell numbers, suggesting that these lncRNAs may play a critical role in Treg cell differentiation and offer new avenues for SLE treatment.
Objective: To investigate the clinical efficacy of plasma exchange (PE) with or without prednisone and hydroxychloroquine (HCQ) for the treatment of systemic lupus erythematosus (SLE) during pregnancy.
Methods: The clinical characteristics of 14 pregnant women with SLE admitted to our hospital were retrospectively analyzed, including 7 only treated with prednisone and HCQ (non-PE group) as well as 7 combined PE (PE group). The delivery situations of 14 patients were recorded.