Publications by authors named "Xing'an Zhang"

Objective: For patients with clinical nodal-negative (cN0) maxillary oral squamous cell carcinoma (MOSCC), neck dissection (ND) and clinical observation are the main two management strategies for the neck. However, the indications corresponding to these two options remain controversial. This study aimed to elucidate the clinical factors affecting ND treatment and to identify clinical characteristics of the population that may benefit from ND based on a retrospective analysis of cN0 MOSCC patient data from the Surveillance, Epidemiology, and End Results (SEER) database.

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Objective To investigate the 50% effective dose(ED)and 95% effective dose(ED)of dexmedetomidine(DEX)combined with 0.032 μg/(kg·h)sufentanil as well as its analgesic effect for patient-controlled intravenous analgesia(PCIA)after video-assisted thoracoscopic surgery(VATS).Methods Totally 25 patients undergoing elective VATS were enrolled.

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Oral cancer remains a deadly disease worldwide. Lymph node metastasis and invasion is one of the causes of death from oral cancer. Elucidating the mechanism of oral cancer lymph node metastasis and identifying critical regulatory genes are important for the treatment of this disease.

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Background: The pharmacodynamics of propofol are closely linked to gender. Dexmedetomidine can decrease propofol needs during propofol anesthesia. The aim of this study was to compare the gender differences on the calculated effect site median effective concentration (EC) of propofol for loss of consciousness (LOC) after pretreatment with different concentrations of dexmedetomidine.

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Article Synopsis
  • A three-compartment population pharmacokinetic model was developed to predict the concentration of intravenously administered propofol using data from five hospitals and analyzed through the NONMEM software.
  • The analysis looked at how factors such as body weight, age, and gender influenced key pharmacokinetic parameters (like clearance and volume distribution) using various models to account for individual variability.
  • The final model demonstrated good predictive ability, with a high determination coefficient (0.91) and stability through methods like Bootstrapping, showing that body weight positively affects clearance and highlights differences in pharmacokinetics between genders and ages.
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