Publications by authors named "Xinfei Dai"
Article Synopsis
- A study evaluated a new growth-friendly system for treating early-onset scoliosis with thoracic insufficiency syndrome (EOS + TIS) in a piglet model, focusing on its impact on pulmonary development.
- Over 12 weeks, the system was implanted after inducing EOS + TIS, and various assessments were made, including X-rays and lung tissue examinations.
- Results showed improved body metrics, lung volume, and reduced scoliosis severity, while also identifying 790 genes related to lung health, indicating the potential for this system to address both scoliosis and lung issues linked to EOS + TIS.
Background: Early-onset scoliosis (EOS) is a scoliosis deformity caused by various reasons before the age of 10 years and is often combined with thoracic insufficiency syndrome (TIS) causing patients with difficulty in securing lung growth in the thoracic cage. Currently, there is a shortage of effective large animal models for evaluating EOS + TIS in therapeutic studies. Consequently, we propose to construct a porcine EOS + TIS model and evaluate its transcriptome changes by RNA sequencing.
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