Diffusion network with spatial channel attention infusion and frequency spatial attention for brain tumor segmentation.

Background: Accurate segmentation of gliomas is crucial for diagnosis, treatment planning, and evaluating therapeutic efficacy. Physicians typically analyze and delineate tumor regions in brain magnetic resonance imaging (MRI) images based on personal experience, which is often time-consuming and subject to individual interpretation. Despite advancements in deep learning technology for image segmentation, current techniques still face challenges in clearly defining tumor boundary contours and enhancing segmentation accuracy.

Expert consensus on One Health for establishing an enhanced and integrated surveillance system for key infectious diseases.

China has been continuously improving its monitoring methods and strategies to address key infectious diseases (KIDs). After the severe acute respiratory syndrome epidemic in 2003, China established a comprehensive reporting system for infectious diseases (IDs) and public health emergencies. The relatively lagging warning thresholds, limited warning information, and outdated warning technology are insufficient to meet the needs of comprehensive monitoring for modern KIDs.

Effects of albiflorin on oxidative stress and inflammatory responses in rats with acute spinal cord injury.

Introduction: Oxidative stress and inflammatory responses are often the predominant detrimental factors associated with spinal cord injury (SCI). This study investigates the potential therapeutic effects of albiflorin (AF) on alleviating inflammation and oxidative stress in the rat model with SCI.

Methods: Initially, the behavior of SCI-induced rats is examined by Basso-Beattie-Bresnahan score and the inclined plane examination.

Association between sleep-wake schedules and myopia among Chinese school-aged children and adolescents: a cross-sectional study.

Background: This study aimed to investigate the relationship between sleep-wake schedules and self-reported myopia in the pediatric population.

Methods: In this cross-sectional study in 2019, school-aged children and adolescents in the Baoan District of Shenzhen City were sampled using a stratified cluster sampling approach. Sleep-wake schedules of children were determined by a self-administered questionnaire.

DNAJB7 is dispensable for male fertility in mice.

Background: DNAJBs are highly conserved proteins that are involved in various biological processes. Although several DNAJBs are highly expressed in the testis, the function of DNAJB7 in spermatogenesis and male fertility remains unclear.

Methods: To identify the role of DNAJB7 in the male reproduction process, Dnajb7-deficient mice were generated by the CRISPR/Cas9-mediated genome editing system.

Supply chain concentration and corporate financialization.

We investigate whether firms that rely on major suppliers or customers, which is defined as supply chain concentration, tend to hold more financial assets than other firms due to supply chain pressure. We find that firms with a higher supply chain concentration have a higher financialization level. The firms' competitive power reduces their financialization level but cannot reverse the adverse impact of supply chain concentration.

Supplier concentration and corporate innovation input.

This paper studies the relationship between supplier concentration and corporate innovation input. The results show that a firm with a higher supplier concentration tends to have lower R&D investments and invention patents. Considering endogenous problems, this negative relationship is still robust by using the instrumental variable regression and propensity score matching method.

Electrophysiological correlates of masked orthographic and phonological priming in Chinese-English bilinguals.

Extensive behavioral and electrophysiological evidence has demonstrated that native translations are automatically activated when bilinguals read non-native words. The present study investigated the impact of cross-language orthography and phonology on Chinese-English bilingual lexicons with a masked priming paradigm. The masked primes and targets were either translation equivalents (TE), orthographically related through translation (OR), phonologically related through translation (PR), or unrelated control (UC).

A regulatory perspective on recombinant collagen-based medical devices.

As a class of novel biomaterials manufactured by synthetic biology technologies, recombinant collagens are candidates for a variety of medical applications. In this article, a regulatory scientific perspective on recombinant collagens and their medical devices is presented with a focus on the definition, translation, classification and technical review. Recombinant collagens are categorized as recombinant human collagen, recombinant humanized collagen and recombinant collagen-like protein, as differentiated by specific compositions and structures.

Prediction of Prognostic Factors and Genotypes in Patients With Breast Cancer Using Multiple Mathematical Models of MR Diffusion Imaging.

Purpose: To explore the clinical value of apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM), and diffusion kurtosis imaging (DKI) based on diffusion-weighted MRI (DW-MRI) for predicting genotypes and prognostic factors of breast cancer.

Materials And Methods: A total of 227 patients with breast cancer confirmed by pathology were reviewed retrospectively. Diffusion-weighted imaging (DWI), IVIM, and DKI were performed in all patients.

Lipidomic biomarkers: Potential mediators of associations between urinary bisphenol A exposure and colorectal cancer.

Previous research reported associations between bisphenol A (BPA) exposure and some malignant tumor incidences, yet the underlying mechanism remains largely uncertain. This investigation was aimed to explore the association of BPA exposure burden with colorectal cancer (CRC) and the role of tumor tissue lipid metabolism in the associations between BPA and CRC using lipidomic approach. Urinary BPA levels in CRC cases were significantly higher than those in controls (P value < 0.

Lead-Free Perovskite Photodetectors: Progress, Challenges, and Opportunities.

State-of-the-art photodetectors which apply hybrid perovskite materials have emerged as powerful candidates for next-generation light sensing. Among them, lead-based ones are the most popular beyond doubt on account of their unique and superior optoelectronic properties. Nevertheless, trade-off toward commercialization exists between nontoxicity and high performance, with the poor stability of lead-based perovskites, indicating that it is indispensable to substitute lead with nontoxic element meanwhile bringing about a comparable figure of merit of photodetectors and relatively long-term stability.

The Clinical Characteristics of Endometrial Cancer With Extraperitoneal Metastasis and the Value of Surgery in Treatment.

Objective: To describe the clinical and pathological features of endometrial carcinoma with extraperitoneal metastasis and examine whether surgery could improve the prognosis.

Methods: The Surveillance, Epidemiology, and End Results database was used to analyze 730 patients who were diagnosed with extraperitoneal metastasis of endometrial cancer from 2010 to 2015, including metastasis to the lung, bone, or brain.

Results: Of the 730 patients, 372 (50.

Analysis of immune-related signatures of colorectal cancer identifying two different immune phenotypes: Evidence for immune checkpoint inhibitor therapy.

Immune checkpoint inhibitor (ICI) therapy has revolutionized the treatment of numerous types of cancer, including colorectal cancer (CRC). Patients with CRC and deficient mismatch repair or high microsatellite instability could benefit from ICI treatment, although the response rate of most patients is low. Therefore, the immune subtyping of patients with CRC is required in order to determine the subtypes suitable for ICI treatment.

Photonic millimeter-wave ultrawideband signal generation using frequency upconversion based on the stimulated Brillouin scattering effect.

We present a novel and simple scheme for photonic generation of a millimeter-wave ultrawideband (UWB) signal free of low-frequency components that is implemented by using a stimulated Brillouin scattering (SBS)-based frequency-doubling method. A dual-parallel Mach-Zehnder modulator is incorporated to generate appropriate optical sidebands and an optical carrier carrying the UWB signal. Then the single-sideband modulation is realized based on the successive SBS frequency shifting process.

Increased Krüppel-like factor 12 impairs embryo attachment via downregulation of leukemia inhibitory factor in women with recurrent implantation failure.

Recurrent implantation failure (RIF) caused by various etiological factors remains a challenge for fertility clinicians using assisted reproductive technology (ART) worldwide. Dysregulation of leukemia inhibitory factor (LIF) in the endometria of women with RIF is involved in impaired endometrial receptivity and embryo adhesion. However, the mechanism through which LIF expression is regulated in women with RIF is still poorly understood.

Facilitated extrinsic majority carrier depletion and photogenerated exciton dissociation in an annealing-free ZnO:C photodetector.

Applications of ZnO in photodetectors are limited by the great quantity of extrinsic majority carriers due to structural defects and difficult exciton dissociation due to the large exciton binding energy; these generally lead to a higher dark current (Id) and lower light current (Il), severely degrading the responsivity and detectivity. C dots are incorporated into an annealing-free ZnO layer to innovatively construct a local built-in electric field (Ebi) using the difference in the work functions; this simultaneously overcomes the drawbacks of the pristine ZnO photosensitive layer. In dark, the extrinsic majority carrier of ZnO is depleted around the incorporated C dots due to the self-depleting effect; thus, the Id decreases.

Extracting Fitness Relationships and Oncogenic Patterns among Driver Genes in Cancer.

Driver mutation provides fitness advantage to cancer cells, the accumulation of which increases the fitness of cancer cells and accelerates cancer progression. This work seeks to extract patterns accumulated by driver genes ("fitness relationships") in tumorigenesis. We introduce a network-based method for extracting the fitness relationships of driver genes by modeling the network properties of the "fitness" of cancer cells.

Engineering the Self-Assembly Induced Emission of Cu Nanoclusters by Au(I) Doping.

Aggregation-induced emission (AIE) and self-assembly induced emission (SAIE) effects have been employed to tune the emission properties of metal nanoclusters (NCs). However, it is still not possible to further enhance the photoluminescence quantum yields (PLQYs) and control the emission colors of the NCs using AIE and SAIE. On the basis of our recent work studying the contribution of Cu(I) defects in the SAIE of Cu NCs, in this article, Au(I) was doped into Cu NC self-assembled nanosheets (NSASs) to construct a more stable Au(I)-centered state.

The diagnostic and prognostic value of serum miR-206 in colorectal cancer.

Circulating microRNAs (miRNAs) are emerging as promising biomarkers for colorectal cancer (CRC). In this study, we sought to examine the diagnostic and prognostic role of serum miR-206 in CRC. A total of 73 CRC cases and 45 healthy control subjects were enrolled in this study.

The effect of self-depleting in UV photodetector based on simultaneously fabricated TiO/NiO pn heterojunction and Ni/Au composite electrode.

A novel dark self-depleting ultraviolet (UV) photodetector based on a TiO/NiO pn heterojunction was demonstrated and exhibited lower dark current (I ) and noise. Both the NiO layer and Ni/Au composite electrode were fabricated by a smart, one-step oxidation method which was first employed in the fabrication of the UV photodetector. In dark, the depleted pn heterojunction structure effectively reduced the majority carrier density in TiO/NiO films, demonstrating a high resistance state and contributing to a lower I of 0.

Organics filled one-dimensional TiO nanowires array ultraviolet detector with enhanced photo-conductivity and dark-resistivity.

A heterojunction photo-conductive ultraviolet (UV) detector was developed based on TiO nanowires array (NWA) surrounded by N,N'-bis-(1-naphthalenyl)-N,N'-bis-phenyl-(1,1'-biphenyl)-4,4'-diamine (NPB). The novel and effective two-step method of static infusion and dynamic solution-cleaning was employed to fill NPB into TiO NWA gaps and simultaneously remove the unwelcomed top NPB layer. The device fabricated via the two-step method exhibited optimal performance compared to TiO/NPB device with top NPB layer and TiO NWA device.

Catalysts of self-assembled Pt@CeO-rich core-shell nanoparticles on 3D ordered macroporous CeZrO for soot oxidation: nanostructure-dependent catalytic activity.

The catalytic performance in heterogeneous catalytic reactions consisting of solid reactants is strongly dependent on the nanostructure of the catalysts. Metal-oxides core-shell (MOCS) nanostructures have potential to enhance the catalytic activity for soot oxidation reactions as a result of optimizing the density of active sites located at the metal-oxide interface. Here, we report a facile strategy for fabricating nanocatalysts with self-assembled Pt@CeO-rich core-shell nanoparticles (NPs) supported on three-dimensionally ordered macroporous (3DOM) CeZrOvia the in situ colloidal crystal template (CCT) method.

Yangjing Capsule extract promotes proliferation of GC-1 spg cells via up-regulated POU3F1 pathway.

As is similar to glial cell line-derived neurotrophic factor (GDNF), the Yangjing Capsule (YC) extract could also lead to proliferation of spermatogonial stem cells (SSCs) by stimulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway; however, the regulatory effect of YC extract on the expression of POU3F1 still remains unknown. The objective of this study is to determine whether the transcription factor POU3F1 is up-regulated by YC extract through the PI3K/AKT signaling pathway to regulate SSCs survival and proliferation. Cultured GC-1 spermatogonial (spg) cells were treated with 0.