Publications by authors named "Xindong Fan"

Objective: This review aims to summarize the salvage experience of cardiopulmonary collapse occurring as a result of absolute ethanol sclerotherapy for vascular malformations.

Methods: In total, we reviewed three cases of cardiopulmonary collapse induced by ethanol sclerotherapy for vascular malformations and described the details of the salvage procedure. Saturation of pulse oxygen (SpO), end-tidal CO, and invasive arterial pressure were the routine monitors for ethanol injection patients.

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Purpose: This study aimed to evaluate the efficacy and safety of ethanol embolization in treating traumatic arteriovenous fistulas (TAVFs).

Materials And Methods: From March 2012 to April 2020, 42 consecutive patients (29.9 ± 15.

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Cobb syndrome is a rare neurocutaneous disease characterized by vascular anomalies involving the skin and spinal cord at the same metamere. The most common initial symptoms are neurological manifestations such as pain, monoparesis, headache, scoliosis, and motor damage. We present two patients with Cobb syndrome and severe disease burden harboring somatic mutations in KRAS.

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Article Synopsis
  • A new study investigates a radiopaque ethanol injection (REI) that combines iopromide and ethanol to improve visibility during interventional therapies for vascular malformations, addressing the risks associated with using pure ethanol.
  • The research involved in vivo testing on 82 male New Zealand white rabbits, comparing different doses of REI and ethanol in procedures like peripheral vein sclerosis and kidney embolization, alongside evaluating safety and pharmacokinetics.
  • Finally, a cohort study was conducted with 6 patients suffering from peripheral venous malformations to assess the clinical safety and effectiveness of the new REI treatment from June to August 2023.
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  • Mandibular arteriovenous malformation (AVM) is a rare condition that can lead to significant oral bleeding, as seen in a case where a 35-year-old woman experienced acute hemorrhage following a tooth extraction.
  • Imaging techniques revealed a vascular mass with invasive bone destruction, leading to a confirmed AVM diagnosis through angiography.
  • The treatment involved using coils to reduce blood flow followed by the injection of absolute ethanol to eliminate the malformation, resulting in no further bleeding and stable condition during a 12-month follow-up.
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Background: Clinically, arteriovenous malformations in the buttocks (bAVMs) are extremely rare. Our study aimed to evaluate the efficacy and safety of ethanol embolotherapy in managing bAVMs.

Results: A total of 32 patients with bAVMs (14 females and 18 males) from 2012 to 2021 were included in this study.

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Based on the latest classification by the International Society for the Study of Vascular Anomalies in 2018, vascular malformations (VMs) can be categorized into simple, combined VMs of major named vessels, and VMs associated with other anomalies. Simple VMs include lymphatic, venous, capillary, and arteriovenous malformations (AVMs). AVMs represent disorders of direct arteriovenous shunts caused by the absence of a capillary bed between the involved arteries and veins.

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A 17-year-old boy with typical neurodevelopment presented with 3 months of lower-limb weakness without a history of trauma. Physical examination, plain radiography and a T2-weighted MRI revealed a port-wine stain over the lumbar region, significant scoliosis below the cervical segment, and a multifocal flow void sign (steal phenomenon) from epidural space to dorso-lumbar spine, respectively (Figure 1). CT angiography identified an enhancing dorsal vascular mass with involvement of the spinal canal including destruction of the vertebral body determined to be extensive arteriovenous shunts on digital subtraction angiography (DSA) (Figure 2).

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Purpose: To investigate the efficacy and safety of interventional embolization in the treatment of frontal arteriovenous malformation (AVM).

Methods: A retrospective study was used to analyze 9 patients with frontal AVM who were treated in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. The patients were treated with interventional embolization under the guidance of DSA.

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Purpose: The present work aimed to determine the different angio-architectural types of palpebral arteriovenous malformations (pAVMs) and appropriate ethanol embolotherapy for each type.

Materials And Methods: This was a multi-center comparative effectiveness research retrospectively conducted from November 2012 to October 2021. A total of 70 patients with pAVMs were included, which was classified into cystic pAVMs (n=29) and diffuse pAVMs (n=41) based on the angio-architecture.

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Article Synopsis
  • The study evaluated the effectiveness of coil-assisted ethanol embolotherapy for head and neck arteriovenous malformations (HNAVMs) that recurred after Onyx treatment, involving 36 patients over a period of 5 years.
  • Results showed that 44.4% of patients had Schobinger stage II HNAVMs, and the majority required staged ethanol embolization, with a notable improvement in the 5-year recurrence-free survival rate to 58.3%.
  • The findings suggest that coil-assisted ethanol embolotherapy is an effective treatment option for patients with refractory HNAVMs after Onyx, demonstrating significant improvements in patient outcomes.
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Objective: In the present study, we summarize our experience in locating the nidus of arteriovenous malformations (AVMs) with a dominant outflow vein (DOV) in the lower extremities and eradicating the nidus with ethanol and coils.

Methods: Twelve patients with lower extremity AVMs who underwent ethanol embolization combined with DOV occlusion from January 2017 to May 2018 were enrolled in the present study. Selective angiography was used to locate the nidus of the AVMs, which was eradicated using ethanol and coils via the direct puncture pathway.

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Background: Venous malformation (VM) is a kind of congenital vascular anomaly with a high incidence of recurrence, detailed pathogenesis and standard treatment of VM still lack now. Increasing evidence showed exosomal RNA plays a pivotal role in various diseases. However, the underlying mechanism of VM based on the potential differentially exosomal RNAs remains unclear.

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Objectives: To summarize the clinical characteristics and investigate the efficacy of ethanol embolotherapy in the treatment of chest well arteriovenous malformation (AVM). Treatment-associated complications were also explored.

Materials And Methods: Between March 2017 and August 2021, 32 consecutive patients (mean age, 23.

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Article Synopsis
  • - The study investigated whether losartan could prevent acute pulmonary arterial pressure elevation (AEPAP) caused by endovascular ethanol injection in male swine, using saline as a control.
  • - Results showed that ethanol injection increased pulmonary arterial pressure and oxidative stress, activating the renin-angiotensin system (RAS) and the P38 MAPK signaling pathway, while losartan did not completely prevent AEPAP but partially mitigated tissue remodeling.
  • - Mechanistic analysis revealed that while losartan inhibited the activation of P38 MAPK, ethanol promoted the activity of NADPH oxidase (NOX), indicating a complex interplay between these pathways in the response to ethanol injection.
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Purpose: Here, we report our experience treating a patient with Maffucci syndrome and evaluate the outcomes resulting from surgical management combined with sclerotherapy in the treatment of head and neck venous malformations (VMs). A 19-years-old woman with multiple enchondromas and heterauxesis complained of masses in the oral cavity that had gradually increased in size and eventually affected her daily life. A tracheotomy was performed followed by traditional sclerotherapy to treat the oropharyngeal VMs.

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Purpose: The aim of this study was to describe the treatment technique, outcomes, and complications of Schobinger stage IV head and neck arteriovenous malformations (HNAVMs) with associated high-output cardiac failure (HOCF) using ethanol and coils with the percutaneous suture technique.

Methods: From January 2015 to December 2019, 19 patients who had HNAVMs with associated HOCF were treated first with a percutaneous suture of the remarkably dilated dominant drainage vein (RDDOV) and subsequent embolization with coils and ethanol. The percutaneous suture of RDDOV was preferred to be performed, followed by the deployment of coils and the injection of absolute ethanol transarterial approach, direct puncture approach, or both of them.

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We aimed to identify a novel prognostic biomarker for head and neck squamous cell carcinoma (HNSCC) based on tumor immunology-related alternative splicing (AS). Data for 502 HNSCC and 44 normal samples were obtained from the TCGA database and used to establish an AS-related risk model through univariate, least absolute shrinkage, and selection operator Cox regression analyses. Fresh HNSCC and normal oral tissues were surgically obtained from 44 HNSCC patients.

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Purpose: Maxillary arteriovenous malformations (AVMs) are uncommon, limiting comprehensive research into standard treatment protocols. This study evaluated the management, outcomes, and clinical safety of embolization techniques for maxillary AVMs, using coils and ethanol.

Methods: In this retrospective case series, we enrolled a sample of patients with maxillary AVMs treated with embolization using coils with or without ethanol between June 2017 and July 2019.

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Background: In absence of the large-sample study of simple peripheral arteriovenous malfomations (pAVM), we aimed to perform the epidemiological analysis of over 1,000 simple pAVM patients from our center in the past 5 years, and establish a novel classification based on the anatomical localization of the primary lesion.

Results: Between March 27, 2016, and March 31, 2021, Chinese patients who were diagnosed with simple pAVM were taken into account. Those who suffered from simple arteriovenous malformations of the central nervous system (cnsAVM), combined types of AVM, and syndromes, such as CLOVES syndrome, etc.

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