Bisphenol S causes excessive estrogen synthesis by activating FSHR and the downstream cAMP/PKA signaling pathway.

Estrogen excess in females has been linked to a diverse array of chronic and acute diseases. Emerging research shows that exposure to estrogen-like compounds such as bisphenol S leads to increases in 17β-estradiol levels, but the mechanism of action is unclear. The aim of this study was to reveal the underlying signaling pathway-mediated mechanisms, target site and target molecule of action of bisphenol S causing excessive estrogen synthesis.

Interacting with luteinizing hormone receptor provides a new elucidation of the mechanism of anti-androgenicity of bisphenol S.

Bisphenol S (BPS) exhibited inhibitory effects on androgen synthesis, but its target of action remains unclear. We investigated the effects of BPS exposure at environmentally relevant concentrations (1 μg/L, 10 μg/L and 100 μg/L) for 48 h on androgen synthesis in rat ovarian theca cells and explored the underlying mechanisms, target site and target molecule. The results showed that BPS exposure inhibited the transcript levels of steroidogenic genes and reduced the contents of androgen precursors, testosterone and dihydrotestosterone.

Design and synthesis of NiCo/CoS@C hybrid material with tunable and efficient electromagnetic absorption.

Producing electromagnetic wave absorbers with high absorption capacity and wide absorption bandwidth is still a challenge task, which limits its application in human life. In this study, a novel carbon-coated NiCo alloy/CoS hybrid material was fabricated by a simple strategy. By adjusting the annealing temperature, the electromagnetic wave absorption property of NiCo/CoS@C hybrid material can be further improved.

Dielectric behavior of FeN@C composites with green synthesis and their remarkable electromagnetic wave absorption performance.

FeN has been considered as a new generation of ideal ferromagnetic materials with the virtues of high saturated magnetization and high resistance to oxidation. However, a facile and eco-friendly fabrication of FeN still needs to be investigated. Herein, the gelatin derived from fish skin was chosen as the raw material of carbon and the amino acid inherent in fish skin can act as a nitrogen source for the generation of FeN.

Determination of eight quinolones in milk using immunoaffinity microextraction in a packed syringe and liquid chromatography with fluorescence detection.

We have established a new, highly selective, and sensitive method for the determination of eight quinolones (QNs) in milk: danofloxacin, enrofloxacin, orbifloxacin, norfloxacin, ofloxacin, lomefloxacin, fleroxacin, and ciprofloxacin. The method uses immunoaffinity microextraction in a packed syringe and liquid chromatography with fluorescence detection (IA-MEPS-LC-FLD). Traditionally, QN residues are determined by liquid-liquid extraction (LLE) and solid phase extraction (SPE) sample preparation techniques; however, these methods are time-consuming and require large quantities of organic solvents.

Development of immunoaffinity solid phase microextraction rods for analysis of three estrogens in environmental water samples.

In this study, immunoaffinity solid phase microextraction (SPME) rods were developed for the analysis of diethylstilbestrol (DES), hexestrol (HES) and dienestrol (DIS) followed by ultra high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). This immunoaffinity SPME device was built with three stainless steel rods bundled together as one and modified with porous silicate particles. As an extraction sorbent, antibody immobilization approach was employed based on the covalent attachment of the anti-diethylstilbestrol monoclonal antibody (mAb) onto the rods.