DNAJA1‑knockout alleviates heat stroke‑induced endothelial barrier disruption via improving thermal tolerance and suppressing the MLCK‑MLC signaling pathway.

Endothelial barrier disruption plays a key role in the pathophysiology of heat stroke (HS). Knockout of DNAJA1 (DNAJA1‑KO) is thought to be protective against HS based on a genome‑wide CRISPR‑Cas9 screen experiment. The present study aimed to illustrate the function of DNAJA1‑KO against HS in human umbilical vein endothelial cells.

CSAC-Net: Fast Adaptive sEMG Recognition through Attention Convolution Network and Model-Agnostic Meta-Learning.

Gesture recognition through surface electromyography (sEMG) provides a new method for the control algorithm of bionic limbs, which is a promising technology in the field of human-computer interaction. However, subject specificity of sEMG along with the offset of the electrode makes it challenging to develop a model that can quickly adapt to new subjects. In view of this, we introduce a new deep neural network called CSAC-Net.

Theoretical study on polynitro imidazo [4, 5-e] oxadiazolo [3, 4-b] pyrazine compounds.

The B3PW91/6-31G** theoretical method was carried out to optimize the structure of 12 polynitro imidazo [4,5-e] oxadiazolo [3,4-b] pyrazine compounds (two structural type). The influence of nitro groups on the structure, oxygen balance, density, heat of formation, detonation performances, and charge were investigated. The results showed that the oxygen balance, density, heat of formation, detonation velocity, detonation pressure, and detonation heat increased with different relationships when the number of nitro groups increased.