Publications by authors named "Xinag-can Shen"
[Spectroscopic studies on the interaction of nicotine and BSA].
Guang Pu Xue Yu Guang Pu Fen Xi
October 2005
Article Synopsis
- The study analyzed how nicotine interacts with bovine serum albumin (BSA) using fluorescence and UV-vis spectra, revealing that nicotine causes a regular quenching of BSA's fluorescence.
- Quenching mechanisms were identified as dynamic at pH 5.0 and static at pH 7.4 and 11.0, with association constants varying according to temperature and pH levels.
- The UV-vis spectra indicated a red shift in BSA's absorbance and a loosening of its secondary structure, suggesting a change from hydrophobic to hydrophilic environments for certain aromatic amino acids in BSA with increased nicotine concentration.