Publications by authors named "Xina Lin"
Objective: To explore the clinical, imaging, pathologic characteristics and differential diagnosis of solitary pulmonary capillary hemangioma (SPCH).
Methods: Thirty two cases of SPCH were collected and studied, with literature review.
Results: This study included 13 males and 19 females, with a male-to-female ratio of 1:1.
Pulmonary artery sarcomas (PAS) are rare with many being undifferentiated pleomorphic or spindle cell (UPSC) sarcomas with variable atypia. The term pulmonary artery intimal sarcoma (PAIS) was rarely coined in the early literature and sometimes used for luminal sarcomas. With the advent of immunohistochemistry and molecular genetics, many of these UPSC sarcomas were found to frequently overpress MDM2 and/or CDK4 and PDGFRA with genetic alterations in 12q12-15 and 4q12, where the MDM2, CDK4 and PDGFRA genes are located.
View Article and Find Full Text PDFPurpose: Adults with T-cell lymphoblastic lymphoma (T-LBL) generally benefit from treatment with acute lymphoblastic leukemia (ALL)-like regimens, but approximately 40% will relapse after such treatment. We evaluated the value of CpG methylation in predicting relapse for adults with T-LBL treated with ALL-like regimens.
Experimental Design: A total of 549 adults with T-LBL from 27 medical centers were included in the analysis.
Article Synopsis
- Researchers developed a gene-expression classifier to predict survival in patients with T-cell lymphoblastic lymphoma (T-LBL), identifying 43 key mRNAs after comparing gene profiles of progressive and progression-free cases.
- The classifier, based on 11 specific genes, was shown to significantly lower progression-free survival, disease-free survival, and overall survival rates for high-risk patients in a training cohort of 169 individuals.
- A prognostic nomogram incorporating the classifier and other factors further improved prediction accuracy for treatment outcomes, indicating that patients with higher scores respond better to the BFM treatment protocol.
New prognostic factors are needed to establish indications for haematopoietic stem cell transplantation (HSCT) in first complete remission (CR1) for T-cell lymphoblastic lymphoma (T-LBL) patients. We used microarray to compare T-LBL tissue samples (n = 75) and fetal thymus tissues (n = 20), and identified 35 differentially expressed miRNAs. Using 107 subjects as the training group, we developed a five-miRNA-based classifier to predict patient survival with LASSO Cox regression: lower risk was associated with better prognosis (disease-free survival (DFS): hazard ratio (HR) 4.
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