Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation.

Ovarian cancer is a highly lethal gynecological malignancy with common platinum resistance. Lactylation is involved in multiple biological processes. Thus, we explored the role of histone and non-histone lactylation in platinum resistance, providing a potential therapeutic target to overcome platinum resistance in ovarian cancer.

FV-429 suppresses cancer cell migration and invasion by EMT via the Hippo/YAP1 pathway in pancreatic cancer cells.

Pancreatic cancer is one of the most common malignant tumors of the digestive system, with the majority of patients not succumbing to the primary tumor but rather to metastasis. Epithelial-mesenchymal transition (EMT) is abnormally activated in numerous cancers, whereby it promotes tumor cell migration and invasion. Yes-associated protein 1 (YAP1) is commonly overexpressed in various cancer types and plays an oncogenic role.

Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case-Control Study in China.

Objective: Here, we ascertained the clinical characteristics of Chinese patients with autoimmune gastritis (AIG) and determined the correlation of dietary and lifestyle factors with AIG occurrence and development to establish a noninvasive predictive model for AIG.

Methods: In this case-control study, we enrolled 479 patients from seven independent centers nationwide in China; of them, 279 had AIG, 112 had chronic atrophic gastritis mostly in the antrum, and 88 had chronic nonatrophic gastritis. Their clinical and lifestyle data were systematically collected and analyzed.

Elucidating Relay Catalysis on Copper Clusters With Satellite Single Atoms for Enhanced Urea Electrosynthesis.

Relay catalysis represents significant efficacy in alleviating competition among different reactants during coupling reactions. However, a comprehensive understanding of the reaction mechanism underlying relay catalysis for the urea electrosynthesis remains challenging. Herein, we have developed a catalyst (Cu-Cu@NC) comprising Cu atomic clusters (Cu) with satellite Cu─N single atoms (Cu) sites on the nitrogen-doped porous interconnected carbon skeleton (NC), enabling elucidation of a relay catalysis process for co-reduction of CO and NO .

A nomogram to predict congestive heart failure in patients with acute kidney injury: a retrospective study based on the MIMIC-III database.

Object: Objective: Acute Kidney Injury (AKI) is a renal disease marked by diminished urine output and elevated serum creatinine levels. AKI has a global incidence rate of about 20%, with an average mortality rate of 23%. Cardiovascular disease emerges as one of the primary causes of death associated with AKI.

Nanomicellar Prodrug Delivery of Glucose-Paclitaxel: A Strategy to Mitigate Paclitaxel Toxicity.

Background: Paclitaxel-induced blood system disorders and peripheral neuropathy impede the progress of new formulations in clinical trials.

Purpose Of Study: To mitigate these adverse effects by developing and validating a prodrug strategy that encapsulates a glucose-paclitaxel conjugate within nanomicelles.

Material And Methods: Succinic anhydride was used as a bridge to couple C2'-paclitaxel with methyl 2'-glucopyranose and prepare a glucose-paclitaxel conjugate.

Design of Decanoic Acid/Polysorbate 80 Composite Vesicles as Cosmetics Carrier: Stability, Skin Permeability, Antioxidant and Antibacterial Activity.

Fatty acid vesicles are natural biomaterials which possess unique bilayer structures and offer biomimetic advantages for drug and gene delivery. Nevertheless, the formation of fatty acid vesicles is limited to neutral alkaline circumstances and cannot adapt to the acidic environment of the living system. In this work, the non-ionic surfactant polysorbate 80 (TW80) was introduced, extending the pH window of vesicles formed by decanoic acid (DA) from 6.

Transcriptomic and Phenotypic Responses of Cucumber Trichome Density to Silver Nitrate and Sodium Thiosulfate Application.

Cucumber ( L.) is one of the most widely cultivated crops worldwide and is valued for its nutritional, economic, and ecological benefits. The regulation of defense mechanisms against herbivores, along with osmotic loss and environmental regulation, is greatly affected by trichomes in cucumbers.

Tailoring the Composite Polymer Electrolytes with Metal-Organic Framework for High-Performance Li-O Batteries.

Lithium-oxygen (Li-O) batteries with high energy density have given rise to tremendous advances in developing highly efficient energy storage devices. However, the barrier of Li dendrite growth and the liquid electrolyte volatilization under semi-open architectures still restrict their future applications. Poly(vinylidene fluoride) (PVDF)-based polymer electrolytes are considered to be an effective solution to these issues, but the presence of highly reactive residual solvents severely disrupts the long-term cycling stability of the battery.

The prognostic and clinical significance of substantial lymphovascular space invasion in early-stage endometrial carcinoma.

Objectives: Substantial lymphovascular space invasion (LVSI) has been incorporated into the 2023 International Federation of Gynecology and Obstetrics (FIGO) staging system for endometrial carcinoma. This study aims to evaluate whether classifying LVSI into substantial LVSI (≥5 involved vessels) and no/focal LVSI (≤4 involved vessels) provides meaningful prognostic differentiation in early-stage endometrial carcinoma.

Methods: We retrospectively enrolled patients with FIGO 2009 stage I-II endometrial carcinoma who underwent surgical staging between January 2013 and August 2020.

Photopyroelectric tweezers for versatile manipulation.

Optical tweezers and related techniques offer extraordinary opportunities for research and applications in physical, biological, and medical fields. However, certain critical requirements, such as high-intensity laser beams, sophisticated electrode designs, additional electric sources, or low-conductive media, significantly impede their flexibility and adaptability, thus hindering their practical applications. Here, we report innovative photopyroelectric tweezers (PPT) that combine the advantages of light and electric field by utilizing a rationally designed photopyroelectric substrate with efficient and durable photo-induced surface charge-generation capability, enabling diverse manipulation in various working scenarios.

Advances in genetic diagnosis and therapy of hereditary heart disease: a bibliometric review from 2004 to 2024.

Hereditary heart disease (HHD) is a series of cardiac disorders associated with monogenic or polygenic abnormalities and is one of the leading causes of sudden death, particularly in young adults. The updated European Cardiology guideline for cardiomyopathies provides the first comprehensive summary of genotyping, imaging, and therapy recommendations for inherited cardiomyopathies, but still lacks a comprehensive discussion of research advances and future trends in genetic diagnosis and therapy of HHD. Our research aims to fill this gap.

"Cu-N" Site-Driven Selectivity Switch for Electrocatalytic CO Reduction.

The comprehensive understanding of the effect of the chemical environment surrounding active sites on the pathway for the electrochemical carbon dioxide reduction reaction (eCORR) is essential for the development of advanced catalysts for large-scale applications. Based on a series of model catalysts engineered by the coordination of copper ions with various isomers of phenylenediamine [i.e.

NesT-NABind: a Nested Transformer for Nucleic Acid-Binding Site Prediction on Protein Surface.

Protein-nucleic acid interactions play a crucial role in many physiological processes. Identifying the binding sites of nucleotides on the protein surface is the prerequisite for understanding the molecular recognition mechanisms between the two types of macromolecules and also provides the information to design or generate molecule modulators against these sites to manipulate biological function according to specific requirements. Existing studies mainly focus on characterizing local surfaces around sites, often neglecting the interrelationships among these sites and the global protein information.

Transformation of Lignin Under Protection Strategies: Catalytic Oxidation and Depolymerization by Polyoxometalates Catalysts.

The efficient utilization of lignin, a pivotal component of lignocellulosic biomass, is crucial for advancing sustainable biorefinery processes. However, optimizing lignin valorization remains challenging due to its intricate structure and susceptibility to undesirable reactions during processing. In this study, we delve into the impact of various pretreatment agents on birch lignin, aiming to enhance its catalytic oxidation and depolymerization under polyoxometalates (POMs) catalysis.

Diagnostic Accuracy of FEF for Bronchial Hyperresponsiveness in Patients with Suspected Asthma and/or Allergic Rhinitis: A Systematic Review and Meta-analysis.

Background: Some studies have suggested that the forced expiratory flow between 25 and 75% of vital capacity (FEF) can be used as an early marker of bronchial hyperresponsiveness (BHR) in asthma and allergic rhinitis (AR), but is highly variable. Here, we aimed to assess whether the FEF can be used to diagnose BHR in patients with asthma-like symptoms and AR.

Methods: PubMed, EMBASE, Web of Science, Wiley Online Library, Cochrane Library, SinoMed, CNKI, and Wanfang Data were searched to acquire eligible studies.

Evolution of endometrial cancer incidence patterns in Hong Kong: A three-decade analysis with future projections.

Objective: This study provides a comprehensive analysis of endometrial cancer incidence trends in Hong Kong over the past three decades. It aims to evaluate the impact of demographic shifts and epidemiological factors, including age, birth cohort, and diagnosis period, on the incidence rates. The study also projects future trends in endometrial cancer cases up to 2030 and assesses the contributions of these factors using a detailed decomposition approach.

Effects of Sizing Agents and Resin-Formulated Matrices with Varying Stiffness-Toughness Ratios on the Properties of Carbon Fiber Epoxy Resin Composites.

Interlaminar shear strength (ILSS) and compressive strength are two of the most critical properties of carbon fiber-reinforced polymer (CFRP). In this report, three types of epoxy resins-4,4'-diaminodiphenylmethane epoxy resin (AG-80), bisphenol A epoxy resin (E-1NT), and novolac epoxy (EPN)-were studied. E-1NT is characterized by low viscosity and low cost but exhibits poor mechanical properties, while AG-80 offers better wetting with carbon fiber.

Host-Guest Interactions of Metal-Organic Framework Enable Highly Conductive Quasi-Solid-State Electrolytes for Li-CO Batteries.

High-energy lithium (Li)-based batteries, especially rechargeable Li-CO batteries with CO fixation capability and high energy density, are desirable for electrified transportation and other applications. However, the challenges of poor stability, low energy efficiency, and leakage of liquid electrolytes hinder the development of Li-CO batteries. Herein, a highly conductive and stable metalorganic framework-encapsulated ionic liquid (IL@MOF) electrolyte system is developed for quasi-solid-state Li-CO batteries.

Multicomponent Heterogeneous Semiconductor Photocatalytic Sulfinylsulfonylation of Alkenes with Alkyl Iodides and SO.

A multicomponent heterogeneous semiconductor photocatalytic sulfinylsulfonylation of alkenes with alkyl iodides and SO was displayed under mild metal-free conditions by using boron carbonitride (BCN) as the alternative photocatalyst. This approach has resulted in the production of a wide range of structurally diverse sultine products in moderate to high yields, using readily available starting materials including alkyl iodides and olefins with broad functional group tolerance. The method is also suitable for the late-stage functionalization of complex bioactive molecules.

Coordination-Driven Crosslinking Electrolytes for Fast Lithium-Ion Conduction and Solid-State Battery Applications.

Rechargeable batteries paired with lithium (Li) metal anodes are considered to be promising high-energy storage systems. However, the use of highly reactive Li metal and the formation of Li dendrites during battery operation would cause safety concerns, especially with the employment of highly flammable liquid electrolytes. Herein, a general strategy by engineering coordination-driven crosslinking networks is proposed to achieve high-performance solid polymer electrolytes.

Tigecycline combined with bronchoscopic interventions in the treatment of macrolide-unresponsive pneumonia: A case report.

(MP) is a common etiological agent of community-acquired pneumonia. However, there has been an increasing incidence of macrolide-unresponsive pneumonia (MUMPP) in recent years. The treatment of MUMPP requires further investigation.

Exploration of the Active Components and Mechanism of Jiegeng (Platycodonis Radix) in the Treatment of Influenza Virus Pneumonia Through Network Pharmacology Analysis and Experimental Verification.

This study aimed to explore the pathogenesis of platycodin D and luteolin, which are both active components in Jiegeng (Platycodonis Radix), in the treatment of influenza virus pneumonia through network pharmacology analysis combined with experimental verification. The bioactive components of Jiegeng (Platycodonis Radix) were screened by TCMSP and literature mining, and the results were standardized via the UniProt database. The action targets for the disease were identified from databases including OMIM, GeneCards, TTD, DisGeNET, and PharmGKB.