Baicalin Decreases the LPS-Induced Intestine Inflammatory Responses by ROS/p-ERK/p-P38 Signal Pathways In Vivo and In Vitro.

This study aimed to investigate the role of ROS/MAPK signaling pathways and the effects of baicalin in LPS-induced inflammatory responses in and porcine intestinal epithelial cells (IPEC-J2). : In vivo, 18 male C57BL/6J were randomly divided into three groups ( = 6): control, LPS (3.5 mg/kg LPS administered intraperitoneally [ip] on day 7), and baicalin (200 mg/kg orally for 7 days, with LPS ip on day 7).

A Theoretical Investigation on the Structural, Electronic and Photocatalytic Properties of BaTaON Adsorbed with Metal Cocatalysts.

We have performed DFT calculations to study the adsorption of single metal atoms (M=Ti, V, Cr, Mn, Fe, Co, Ni, Cu) on both BaO- and TaON-terminated surfaces of cis-BaTaON (001). We have identified the most stable adsorption configuration of each case and explored the relative stability, structural deformations, charge transfer, work function, density of states and mechanism of photocatalytic HER. For BaO termination, all of the adatoms bind covalently on top of the surface oxygens.

Boosting Li-CO Battery Performance via High-Entropy Alloy Catalysts: Insights into Configurational Entropy Effect.

Li-CO batteries have attracted considerable attention for their ability to combine CO fixation and conversion with high-density energy storage. However, sluggish kinetics of CO reduction and evolution reactions at cathodes lead to large overpotentials and poor cyclic stability. To address this issue, it is critical to develop advanced cathode catalysts.

A Hydrogel Electrolyte-Based Zn-CO Battery with Improved Life.

Environmental-friendly aqueous Zn-CO batteries present bifunctional potentials of achieving carbon neutrality and energy storage. Nonetheless, anode corrosions derived from HO molecules and high risks of volatilization and leakage hinder the advancement of Zn-CO batteries. In this work, polyvinyl alcohol (PVA)-based hydrogel electrolyte with fast ion diffusion kinetics, high mechanical strength, and flexibility is developed to replace liquid electrolyte.

Minimizing Zn Loss Through Dual Regulation for Reversible Zinc Anode Beyond 90% Utilization Ratio.

Large-scale energy storage devices experience explosive development in response to the increasing energy crisis. Zinc ion batteries featuring low cost, high safe, and environment friendly are considered promising candidates for next-generation energy storage devices. However, their practical application suffers from the limited anode lifespan under a high zinc utilization ratio, which can be attributed to aggravated Zn loss caused by zinc conversion reactions and "dead" Zn.

Long-Life Zinc Anodes via Molecular-Layer-Deposited Inorganic-Organic Hybrid Titanicone Thin Films.

Zinc-ion batteries (ZIBs) have consistently faced challenges related to the instability of the zinc anode. Uncontrolled dendrite growth, hydrogen evolution reaction (HER), and byproduct accumulation on the zinc anode severely affect the cycling life of ZIBs. Herein, inorganic-organic hybrid thin films of titanicones (Ti-based hydroquinone, TiHQ) were fabricated by molecular layer deposition (MLD) technology to modify the zinc metal anode.

Targeting uric acid: a promising intervention against oxidative stress and neuroinflammation in neurodegenerative diseases.

Oxidative stress and neuroinflammation are recognized as key factors in the development of neurodegenerative diseases, yet effective interventions and biomarkers to address oxidative stress and neuroinflammation in these conditions are limited. Uric acid (UA), traditionally associated with gout, is now gaining prominence as a potential target in neurodegenerative diseases. Soluble UA stands out as one of the most vital antioxidant compounds produced by the human body, accounting for up to 55% of the extracellular capacity to neutralize free radicals.

Placental extracellular vesicles induce ovarian tumour cell death in an ex vivo explant model: Possible therapeutic potential.

Introduction: Placental extracellular vesicles (EVs), lipid-enclosed particles released from the placenta, can facilitate intercellular communication and are classified as micro- or nano-EVs depending on size. Placental EVs contain molecules associated with cell proliferation and death. In this study, we investigated whether treating human ovarian tumour explants with placental EVs could induce ovarian tumour cell death.

Precise Synthesis of 4.75 V-Tolerant LiCoO with Homogeneous Delithiation and Reduced Internal Strain.

The rapid advancements in 3C electronic devices necessitate an increase in the charge cutoff voltage of LiCoO to unlock a higher energy density that surpasses the currently available levels. However, the structural devastation and electrochemical decay of LiCoO are significantly exacerbated, particularly at ≥4.5 V, due to the stress concentration caused by more severe lattice expansion and shrinkage, coupled with heterogeneous Li intercalation/deintercalation reactions.

Predictive risk factors for adverse events during tooth extraction among elderly patients with cardiovascular diseases.

Background: Tooth extraction is a risk factor for cardiovascular events, particularly in elderly patients. However, no clinical tool has been developed to date to predict the risk of adverse events (AEs) during tooth extraction.

Materials And Methods: We prospectively enrolled 774 elderly patients (aged ≥ 60 years) with cardiovascular disease (CVD) who were scheduled to undergo tooth extraction at the dental surgery department of Shanghai Ninth People's Hospital from January 2021 to July 2022.

Inhibition of CDH11 Activates cGAS-STING by Stimulating Branched Chain Amino Acid Catabolism and Mitigates Lung Metastasis of Adenoid Cystic Carcinoma.

Salivary adenoid cystic carcinoma (SACC) is an intractable malignant tumor originates in the secretory glands and frequently metastasizes to the lungs. Hybrid epithelial-mesenchymal transition (EMT) cells within the tumors are correlated with augmented proliferative capacity and facilitation of lung metastasis. Single-cell RNA sequencing and spatial transcriptomic sequencing are employed to reveal the hybrid EMT subsets within the vascular fibroblast microenvironment.

Determining the Optimal Age for Extracranial-Intracranial Bypass Surgery: A Post Hoc Analysis of the CMOSS Randomized Trial.

Background: Previous trials have failed to demonstrate the benefits of extracranial-intracranial (EC-IC) bypass surgery for patients with carotid or middle cerebral artery occlusion. However, little evidence has focused on the effect of age on prognosis. This study aimed to explore whether EC-IC bypass surgery can provide greater benefits than medical therapy alone in specific age groups.

Complications and patient-reported outcomes after radiotherapy in breast cancer patients undergoing implant-based breast reconstruction: a retrospective study from a large Chinese breast disease center.

Background: Postmastectomy radiation therapy (PMRT) can influence the outcome of implant-based breast reconstruction (IBBR). This study aims to investigate the complications and patient-reported outcomes (PROs) following PMRT between direct-to-implant (DTI) and tissue expander-to-implant (TEI) reconstruction.

Methods: The retrospective study included breast cancer patients undergoing IBBR and PMRT.

Baicalin methyl ester prevents the LPS - induced mice intestinal barrier damage in vivo and in vitro via P65/TNF-α/MLCK/ZO-1 signal pathway.

The effect of baicalin methyl ester (BME) on the regulation of mice intestinal barrier in the inflammatory response was studied in vivo and in vitro. Thirty six C57/BL mice were randomly divided into six groups (n = 6): control group; LPS group (LPS 3.5 mg/kg given intraperitoneal [ip] on day 7 of the study only), PBS group, and three BME groups (low: 50 mg/kg; medium: 100 mg/kg; high: 200 mg/kg) orally dosed with BME for 7d and LPS ip on day 7.

Extract toolkit for essential oils: State of the art, trends, and challenges.

Plant essential oils have a wide range of applications including cosmetics, food, leather, and textiles. Traditional methods employed for essential oils extraction suffer from several drawbacks, which have escalated into a major bottleneck for industrial applications. To circumvent the limitations, various innovative and eco-friendly technologies have emerged for the extraction of essential oils, such as ultrasound-assisted extraction, pulsed electrical-assisted extraction, ohmic-assisted technology, supercritical fluid extraction, and solvent-free microwave extraction.

Tailoring the Electrode-Electrolyte Interface for Reliable Operation of All-Climate 4.8 V Li||NCM811 Batteries.

Combining high-voltage nickel-rich cathodes with lithium metal anodes is among the most promising approaches for achieving high-energy-density lithium batteries. However, most current electrolytes fail to simultaneously satisfy the compatibility requirements for the lithium metal anode and the tolerance for the ultra-high voltage NCM811 cathode. Here, we have designed an ultra-oxidation-resistant electrolyte by meticulously adjusting the composition of fluorinated carbonates.

Maternal smoking during pregnancy could accelerate aging in the adulthood: evidence from a perspective study in UK Biobank.

Background: Maternal smoking during pregnancy (MSDP) is significantly linked to the short- or long-term health of offspring. However, little research has examined whether MSDP affect the aging rate of offspring.

Methods: This study used questionnaires to determine out whether the participants' mothers smoked when they were pregnant.

An inorganic molten salt electrolyte-based Li-CO battery with moderate working temperature and enhanced performance.

Herein, a binary inorganic molten salt electrolyte based on lithium bis(fluorosulfonyl)imide (LiFSI) and potassium bis(fluorosulfonyl)imide (KFSI) is applied to Li-CO batteries that can operate under 80 °C. Benefiting from the intrinsic nonvolatility, electrochemical stability, raised ionic conductivity, sufficient solubility and safety, the molten electrolyte endows the Li-CO battery with a large discharge capacity of 4612 mA h g and superior rate capability. The introduction of the Ru@Super P carbon cathode further optimizes the discharge capacity (9503 mA h g), overpotential (1.

Carotid revascularisation versus medical treatment for asymptomatic carotid artery stenosis.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To compare the safety and efficacy of carotid revascularisation plus best medical treatment with best medical treatment alone in people with asymptomatic carotid artery stenosis.

A Rechargeable "Rocking Chair" Type Zn-CO Battery.

Rising global temperatures and critical energy shortages have spurred researches into CO fixation and conversion within the realm of energy storage such as Zn-CO batteries. However, traditional Zn-CO batteries employ double-compartment electrolytic cells with separate carriers for catholytes and anolytes, diverging from the "rocking chair" battery mechanism. The specific energy of these conventional batteries is constrained by the solubility of discharge reactants/products in the electrolyte.