Prediction of high- superconductivity in HSX below megabar pressure.

The discovery of high critical temperature in cubic HS under high pressures attracts significant attention. Of particular recent interest is to search for superconductors stabilized at low pressure in order to approach practical applications. To examine the doping effect on the stability and superconductivity of HS, we construct HSX by replacing half of the S atoms with an X atom (X = Si, Ge, Sn, P, As, Sb, Te, Cl, Br and I).

Effective Improvement of Thermodynamics and Kinetics of BiVO Photoanode via CuI for Photoelectrochemical Water Oxidation.

The preparation of durable and efficient photoanodes for photoelectrochemical water oxidation is of great importance in promoting the development of green hydrogen production and artificial photosynthesis. Here, n-type BiVO was combined with p-type CuI to construct a CuI/BiVO (CIB-1) p-n heterojunction photoanode. The composite photoanode effectively overcame the drawbacks of BiVO, such as low separation and injection efficiency of photogenerated electron-hole pairs.

A receptor kinase senses sterol by coupling with elicitins in auxotrophic .

Sterols are vital nutrients and signals for eukaryotic organisms. Mammalian cells are known to sense and respond to sterol status changes to maintain them within strict limits, a process associated with various human diseases. However, this process is not understood in oomycete pathogens, most of which are sterol auxotrophic and must obtain sterols from host plants.

A Nanopore-sequenced high-quality genome of the strain Bo-1.

Brown spot disease of rice caused by results in severe yield losses. A high-quality genome was assembled using Nanopore sequencing data, resulting in a 36-Mb nuclear genome with 19 contigs and a mitogenome. This assembly provides valuable genetic resources for investigations of rice- interactions.

Effects of genetically proxied statins on diabetic nephropathy and retinopathy: a Mendelian randomization study.

There is no reliable causal evidence for the effect of statins on diabetic nephropathy (DN) and diabetic retinopathy (DR), and the results of previous observational studies are contradictory. Genetic variants linked to low-density lipoprotein cholesterol (LDL-C) from a UK biobank genome-wide association study and located within a 100kb window around HMGCR were used to proxy statins, comparing with PCSK9 inhibitors (control). DN and DR genome-wide association study summary statistics were obtained from the FinnGen study.

Tumor-infiltrating T lymphocytes: A promising immunotherapeutic target for preventing immune escape in cholangiocarcinoma.

Cholangiocarcinoma (CCA) is becoming more common and deadly worldwide. Tumor-infiltrating T cell subtypes make distinct contributions to the immune system; collectively, they constitute a significant portion of the tumor microenvironment (TME) in CCA. By secreting cytokines and other chemicals, regulatory T cells (Tregs) decrease activated T cell responses, acting as immunosuppressors.

Integrated platform for multiscale molecular imaging and phenotyping of the human brain.

Understanding cellular architectures and their connectivity is essential for interrogating system function and dysfunction. However, we lack technologies for mapping the multiscale details of individual cells and their connectivity in the human organ-scale system. We developed a platform that simultaneously extracts spatial, molecular, morphological, and connectivity information of individual cells from the same human brain.

Long-chain fatty acids - The turning point between 'mild' and 'severe' acute pancreatitis.

Acute pancreatitis (AP) is an inflammatory disease characterized by localized pancreatic injury and a systemic inflammatory response. Fatty acids (FAs), produced during the breakdown of triglycerides (TGs) in blood and peripancreatic fat, escalate local pancreatic inflammation to a systemic level by damaging pancreatic acinar cells (PACs) and triggering M1 macrophage polarization. This paper provides a comprehensive analysis of lipases' roles in the onset and progression of AP, as well as the effects of long-chain fatty acids (LCFAs) on the function of pancreatic acinar cells (PACs).

A MYB-related transcription factor regulates effector gene expression in an oomycete pathogen.

Phytophthora pathogens possess hundreds of effector genes that exhibit diverse expression patterns during infection, yet how the expression of effector genes is precisely regulated remains largely elusive. Previous studies have identified a few potential conserved transcription factor binding sites (TFBSs) in the promoters of Phytophthora effector genes. Here, we report a MYB-related protein, PsMyb37, in Phytophthora sojae, the major causal agent of root and stem rot in soybean.

Mechanism of efficient adsorption for arsenic in aqueous solution by zeolitic imidazolate framework‑8.

Arsenic (As) is one extremely hazardous and carcinogenic metalloid element. Due to mining, metal smelting, and other human activities, the pollution of water (especially groundwater) and soil caused by As is increasingly serious, which badly threatens the environment and human health. In this study, a zeolite imidazolate framework (ZIF-8) was synthesized at room temperature and employed as an adsorbent to facilitate the adsorption of As(III) and As(V) from the solution.

Ferroptosis exacerbates hyperlipidemic acute pancreatitis by enhancing lipid peroxidation and modulating the immune microenvironment.

Abnormal activation of ferroptosis worsens the severity of acute pancreatitis and intensifies the inflammatory response and organ damage, but the detailed underlying mechanisms are unknown. Compared with other types of pancreatitis, hyperlipidemic acute pancreatitis (HLAP) is more likely to progress to necrotizing pancreatitis, possibly due to peripancreatic lipolysis and the production of unsaturated fatty acids. Moreover, high levels of unsaturated fatty acids undergo lipid peroxidation and trigger ferroptosis to further exacerbate inflammation and worsen HLAP.

Interaction of acetylcholine and oxytocin neuromodulation in the hippocampus.

A postulated role of subcortical neuromodulators is to control brain states. Mechanisms by which different neuromodulators compete or cooperate at various temporal scales remain an open question. We investigated the interaction of acetylcholine (ACh) and oxytocin (OXT) at slow and fast timescales during various brain states.

infection and Toll-like receptors.

consists of gram-negative bacteria that have the ability to invade and replicate in professional and non-professional phagocytes, and its prolonged persistence in the host leads to brucellosis, a serious zoonosis. Toll-like receptors (TLRs) are the best-known sensors of microorganisms implicated in the regulation of innate and adaptive immunity. In particular, TLRs are transmembrane proteins with a typical structure of an extracellular leucine-rich repeat (LRR) region and an intracellular Toll/interleukin-1 receptor (TIR) domain.

Juice Vesicles Bioreactors Technology for Constructing Advanced Carbon-Based Energy Storage.

The construction of high-quality carbon-based energy materials through biotechnology has always been an eager goal of the scientific community. Herein, juice vesicles bioreactors (JVBs) bio-technology based on hesperidium (e.g.

A "messenger zone hypothesis" based on the visual three-dimensional spatial distribution of motoneurons innervating deep limb muscles.

Coordinated contraction of skeletal muscles relies on selective connections between the muscles and multiple classes of the spinal motoneurons. However, current research on the spatial location of the spinal motoneurons innervating different muscles is limited. In this study, we investigated the spatial distribution and relative position of different motoneurons that control the deep muscles of the mouse hindlimbs, which were innervated by the obturator nerve, femoral nerve, inferior gluteal nerve, deep peroneal nerve, and tibial nerve.

Enhanced degradation of chloramphenicol via heterogeneous activation of peroxymonosulfate by FeO and gallic acid.

In this study, we demonstrated the effective degradation of wide-spectrum antibiotic chloramphenicol (CAP) by FeO/peroxymonosulfate (PMS) system modified by gallic acid (GA). GA/Fe3O4/PMS showed a substantially higher degradation rate (77.6%) than FeO/PMS (8.

Synergy Effect of the Enhanced Local Electric Field and Built-In Electric Field of CoS/Mo-Doped BiVO for Photoelectrochemical Water Oxidation.

Bismuth vanadate is a promising material for photoelectrochemical water oxidation. However, it suffers from a low quantum efficiency, poor stability, and slow water oxidation kinetics. Here, we developed a novel photoanode of CoS/Mo-BiVO with excellent photoelectrochemical water oxidation performance.

Transcriptomic Analysis of the Rat Dorsal Root Ganglion After Fracture.

In fractures, pain signals are transmitted from the dorsal root ganglion (DRG) to the brain, and the DRG generates efferent signals to the injured bone to participate in the injury response. However, little is known about how this process occurs. We analyzed DRG transcriptome at 3, 7, 14, and 28 days after fracture.

Reed microstructure detection by optical coherence tomography, an efficient and non-invasive method.

Woodwind instrument reeds are commonly made from Arundo donax Linn (ADL) material. The mechanical properties of ADL significantly influence the acoustic behavior of the reed, thereby affecting the instrument's overall performance. Current investigations into the internal microstructure of reeds are primarily conducted through optical microscopy, a method that involves cutting open the sample and observing its morphological features, thereby causing irreversible damage to the specimen.

Comparative Microscopic, Transcriptome and IAA Content Analyses Reveal the Stem Growth Variations in Two Cultivars .

is not only an excellent ornamental tree species for courtyards, but it is also a popular bonsai tree. 'Oosterwijk' and 'Red sprite' are two varieties of . The former has a long stem with few branches, while the latter has a short stem.

Transcriptome Analysis Reveals the Response Mechanism of , and under 4,8-Dihydroxy-1-tetralone Treatment.

4,8-dihydroxy-l-tetralone (4,8-DHT) is an allelochemical isolated from the outer bark of that acts as a plant growth inhibitor. In order to explore the mechanism of 4,8-DHT inhibiting weed activity, we treated three species of , and with different concentrations of 4,8-DHT and performed phenotype observation and transcriptome sequencing. The results showed that with an increase in 4,8-DHT concentration, the degree of plant damage gradually deepened.

MicroRNA-142a-3p regulates neurogenic skeletal muscle atrophy by targeting Mef2a.

Peripheral nerve injury can lead to progressive muscle atrophy and poor motor function recovery, which is a difficult point of treatment, and the mechanism needs to be further explored. In previous studies, we found that miR-142a-3p was significantly upregulated and persistently highly expressed in denervated mouse skeletal muscle. Here, we show that overexpression of miR-142a-3p inhibited the growth and differentiation of C2C12 myoblast, while knockdown of miR-142a-3p had a promoting effect.

Serum metabolomics strategy for investigating the hepatotoxicity induced by different exposure times and doses of (Lour.) Merr. in rats based on GC-MS.

(Lour.) Merr. (GS), has been widely used in Chinese folk medicine and can promote circulation, relieve pain and remove stasis.