A fault diagnosis method for rolling bearing based on gram matrix and multiscale convolutional neural network.

The safety and reliability of rotating machinery hinge significantly on the proper functioning of rolling bearings. In the last few years, there have been significant advances in the algorithms for intelligent fault diagnosis of bearings. However, the vibration signals collected by machines are inevitably affected by irrelevant noise because of the complex working environments of bearings.

Preparation of quaternary ammonium lignosulfonate modified UV resistant polyurethane and its application in leather dyeing.

Applying cationic waterborne polyurethane (CWPU) in the leather color-fixing process can improve the dyeing rate and enhance color fastness. However, under prolonged exposure to sunlight, CWPU will age and degrade and the leather will fade in color, become stiff and crack easily. In this study, an Ultraviolet absorber was introduced into cationic waterborne polyurethane (UVCWPU) and quaternary ammonium Lignosulfonate (QLS) was prepared by quaternization.

Metagenomic next-generation sequencing and galactomannan testing for the diagnosis of invasive pulmonary aspergillosis.

To evaluate the diagnostic value of metagenomic next-generation sequencing (mNGS) and galactomannan (GM) testing in invasive pulmonary aspergillosis (IPA) and to compare mNGS with other diagnostic approaches (serum/bronchoalveolar lavage fluid (BALF)-GM and conventional microbiological tests (CMTs) including sputum smears and culture, BALF fungal culture, and bronchial brushing). In all, 237 patients were enrolled in this retrospective study, including 120 patients with IPA and 117 with non-IPA pulmonary infections treated at Henan Provincial People's Hospital between June 2021 and February 2024. The diagnostic performance of mNGS was compared to conventional diagnostic methods including serum GM, BALF-GM, sputum smear microscopy, sputum culture, bronchial brushings, and BALF culture.

Mitochondrial Dysfunction and Metabolic Indicators in Patients with Drug-Naive First-Episode Schizophrenia: A Case-Control Study.

Objective: This paper aims to explore the expression characteristics of mitochondrial function-related genes in patients with first-episode schizophrenia (SCZ)and the correlation between differentially expressed genes and clinical metabolic indicators.

Methods: Twenty patients with first-episode SCZ who had not taken antipsychotic drugs (patient group) and twenty healthy controls (control group) were included. Quantitative real-time PCR technology was used to detect the expression levels of genes related to mitochondrial quality control and oxidative phosphorylation in peripheral blood leukocytes, and metabolic indicators such as blood biochemistry and blood glucose were collected.

Comparative analysis of the nutritional composition, digestibility, metabolomics profiles and growth influence of cow, goat and sheep milk powder diets in rat models.

Introduction: The diversity of dairy products and the increasing consumption levels have led to a growing interest in goat and sheep milk, which are rich in essential nutrients and functional components. The study aims to explore the nutritional composition, growth performance, digestibility, and serum metabolic differences of milk powders from cow, goat, and sheep using LC-MS/MS-based metabolomics in rat models.

Methods: Sixty male Sprague-Dawley rats were fed with whole cow, goat, and sheep milk powder samples , and their feces and urine were analyzed for fat and protein content.

Accumulation of phenolic in fresh-cut lotus roots induced by thermosonication: Regulation of phenylpropanoid pathway and reactive oxygen species metabolism.

The aim of this study is to investigate the effects of thermosonication (TS) on the phenolic accumulation of fresh-cut lotus roots (FCLs) in the context of the phenylpropanoid pathway and reactive oxygen species (ROS) metabolism. The potential regulatory effects of phenolic synthesis triggered by ROS signaling molecules during TS treatment were determined. Results showed that TS treatment significantly activated the activities of key enzymes associated with phenylpropanoid metabolism in FCLs, resulting in an increase in the total phenolic content (TPC), including gallic acid, epicatechin and rutin, consequently enhancing the antioxidant capacity.

Peripheral and central innervation pattern of mechanosensory neurons in the trigeminal ganglion.

The trigeminal ganglion (TG) comprises primary sensory neurons responsible for orofacial sensations, subsequently projecting to the trigeminal nuclei in the brainstem. However, the circuit basis of nasal mechanosensation is not well characterized. Here we elucidate the anatomical organization of both peripheral and central projections of the TG.

Causal relationship between immune cells and Guillain-Barré syndrome: a Mendelian randomization study.

Objective: The aim of this study was to investigate the causal effect of immune cell phenotype on GBS using two-sample Mendelian randomization (MR) approach.

Methods: This study used MR to investigate the causal relationship between 731 immune cell phenotypes and GBS. We used Inverse variance weighted, Weighted median, MR Egger, Simple mode, Weighted mode for MR analysis.

Dynamics of an SVEIR transmission model with protection awareness and two strains.

As of May 2024, the main strains of COVID-19 caused hundreds of millions of infection cases and millions of deaths worldwide. In this study, we consider the COVID-19 epidemics with the main strains in the Chinese mainland. We study complex interactions among hosts, non-pharmaceutical interventions, and vaccinations for the main strains by a differential equation model called SVEIR.

Photonic Generation of Arbitrary Microwave Waveforms with Anti-Dispersion Transmission Capability.

We propose and demonstrate a photonic-assisted approach for generating arbitrary microwave waveforms based on a dual-polarization dual-parallel Mach-Zehnder modulator, offering significant advantages in terms of tunability of repetition rates and anti-dispersion capability. In order to generate diverse microwave waveforms, two sinusoidal radio frequency signals with distinct frequency relationships are applied to the dual-polarization dual-parallel Mach-Zehnder modulator. By adjusting the power of the applied sinusoidal radio frequency signal, the power ratio between these orthogonal polarized optical sidebands can be changed, and thereby desired radio frequency waveforms can be obtained after photoelectric conversion.

Emerging Roles of IL-27 in Trophoblast Cells and Pregnancy Complications.

Problem: Pregnancy complications such as spontaneous abortion, preeclampsia, and preterm birth persist, despite current interventions aimed at their prevention and treatment largely proving unsuccessful. Interleukin-27 (IL-27), composed of p28 and EBI3 subunits, binds to IL-27R, which consists of gp130 and IL-27Rα (also known as WSX-1 or TCCR), and plays a pivotal role in tumor development and inflammation regulation. At the maternal-fetal interface, IL-27 expression has been detected in trophoblasts, endometrial stromal cells, and decidual cells.

Propane wet reforming over PtSn nanoparticles on γ-AlO for acetone synthesis.

Acetone serves as an important solvent and building block for the chemical industry, but the current industrial synthesis of acetone is generally accompanied by the energy-intensive and costly cumene process used for phenol production. Here we propose a sustainable route for acetone synthesis via propane wet reforming at a moderate temperature of 350 C with the use of platinum-tin nanoparticles supported on γ-aluminium oxide (PtSn/γ-AlO) as catalyst. We achieve an acetone productivity of 858.

The Role and Mechanism of Vascular Aging in Geriatric Vascular Diseases.

Vascular aging is the pathological basis for the aging of various organ systems in the human body and is a common pathogenesis leading to the development of atherosclerosis, Alzheimer's disease, and other conditions among older adults. Aging is characterized by accelerated pulse wave velocity, thickening of the carotid artery intima-media, and decreased vascular dilation function. Signaling pathways such as mTOR, AMPK, NF-κB, Klotho, SIRT, and other key proteins are likely involved in these processes.

Preparation of Stainless Steel Superhydrophobic Surface and Analysis of Hydrophobic Mechanism.

By analyzing the application conditions of hydrothermal oxidation equipment, we found that the corrosion resistance of stainless steel is crucial. It is necessary to prepare superhydrophobic surface to improve the corrosion resistance and find a cost-effective and environmentally friendly preparation method. Therefore, this paper proposes a method combining nanosecond laser and post-treatment, which uses nanosecond laser to etch microstructure and reduces the surface energy through diverse post-treatment methods to achieve hydrophobicity.

Influence of race and age in sleep duration and mortality relationship among adults in the United States: results from the 2004 NHIS-NDI record linkage study.

Unlabelled: Limited information exists on age and racial disparities in sleep duration and mortality in the United States (US) population. This study compared the association between mortality and sleep duration within distinct races and age groups in the US. This study used data on 26,915 US citizens (≥ 18 years) from the 2004 wave of the National Health Interview Survey, linked to the National Death Index prospective mortality through 2019.

An Integrated Approach of Network Pharmacology, Bioinformatics, Molecular Docking, and Experimental Verification Uncovers Prunellae Spica as the potential Medicine of Prognosis Improvement for Oral Squamous Cell Carcinoma.

Background: Prunellae Spica (PS), the spike from Prunella vulgaris L., is a traditional Chinese medicine that can treat Oral Squamous Cell Carcinoma (OSCC), whereas its molecular mechanisms and effects on the prognosis of patients remain unclear.

Methods: Our study aimed to identify potential anti-OSCC targets of PS and explore its mechanisms and effects on prognosis through network pharmacology, bioinformatics analysis, molecular docking, and in vitro cell assays.

Polysaccharides from Hericium erinaceus and its immunomodulatory effects on RAW 264.7 macrophages.

This study aimed to optimize the extraction of Hericium erinaceus polysaccharides (HEP) using ultrasound-assisted enzymatic extraction combined with Plackett-Burman design (PBD) and response surface methodology (RSM). The optimal extraction conditions were identified as: 33 min extraction time, 30:1 liquid to material ratio, 38 °C extraction temperature, 9 g/kg cellulase amount, pH 4, and 20 % ethanol concentration. Under these conditions, the extraction yield of HEP was 5.

Tyrosine Kinase 2 Inhibition With Zasocitinib (TAK-279) in Psoriasis: A Randomized Clinical Trial.

Importance: New, effective, and well-tolerated oral therapies are needed for treating psoriasis. Zasocitinib, a highly selective allosteric tyrosine kinase 2 (TYK2) inhibitor, is a potential new oral treatment for this disease.

Objective: To assess the efficacy, safety, and tolerability of zasocitinib in patients with moderate to severe plaque psoriasis.

Impaired IL-27 signaling aggravates macrophage senescence and sensitizes premature ovarian insufficiency induction by high-fat diet.

Premature ovarian insufficiency (POI) critically affects female reproductive health, with obesity being a significant and recognized risk factor. Interleukin-27 (IL-27), known for its role in immune modulation and inflammation, has garnered attention in metabolic syndrome research. Nonetheless, the role of these immunometabolic factors on the initiation of POI remains to be unraveled.

Ruthenium Single-Atom Modulated Protonated Iridium Oxide for Acidic Water Oxidation in Proton Exchange Membrane Electrolysers.

Proton exchange membrane water electrolysers promise to usher in a new era of clean energy, but they remain a formidable obstacle in designing active and durable electrocatalysts for the acidic oxygen evolution reaction (OER). In this study, a protonated iridium oxide embedded with single-atom dispersed ruthenium atoms (HIr RuO) that demonstrates exceptional activity and stability in acidic water oxidation is introduced. The single Ru dopants favorably induce localized oxygen vacancies in the Ir─O lattice, synergistically strengthening the adsorption of OOH* intermediates and enhancing the intrinsic OER activity.