LRP1B associated with immune cell infiltration influenced the efficacy of immunotherapy in colorectal cancer patients.

Objective: Colorectal cancer is one of the most common malignant tumors in the world, which seriously threatens human health. It is essential for the search for new oncogene targets in colorectal cancer.

Methods: Samples from 57 colorectal cancer patients were collected in this study.

Relieving Stress Concentration through Anion-Cation Codoping toward Highly Stable Nickel-Rich Cathode.

Nickel-rich LiNiCoAlO (NCA) with excellent energy density is considered one of the most promising cathodes for lithium-ion batteries. Nevertheless, the stress concentration caused by Li/Ni mixing and oxygen vacancies leads to the structural collapse and obvious capacity degradation of NCA. Herein, a facile codoping of anion (F)-cation (Mg) strategy is proposed to address these problems.

Hybrid Slime Mold and Arithmetic Optimization Algorithm with Random Center Learning and Restart Mutation.

The slime mold algorithm (SMA) and the arithmetic optimization algorithm (AOA) are two novel meta-heuristic optimization algorithms. Among them, the slime mold algorithm has a strong global search ability. Still, the oscillation effect in the later iteration stage is weak, making it difficult to find the optimal position in complex functions.

Role of epithelial cell-mesenchymal transition regulators in molecular typing and prognosis of colon cancer.

Background: Despite advances in colon cancer screening, diagnosis, chemotherapy, and targeted therapy, the prognosis remains poor once colon cancer develops distant metastasis or local recurrence. To further improve the prognosis of colon cancer patients, researchers or clinicians may need to identify new indicators for predicting the prognosis and treatment of colon cancer.

Methods: In order to discover the new mechanism of epithelial-mesenchymal transition (EMT) promoting tumor progression and to find new indicators of colon cancer diagnosis, targeted therapy and prognosis, this study conducted The Cancer Genome Atlas (TCGA) analysis, differential gene analysis, prognostic analysis, protein-protein interaction (PPI), enrichment analysis, molecular typing, and a machine algorithm were combined with data from TCGA and Gene Expression Omnibus (GEO) databases and EMT-related genes.

Ultrathin acoustic metamaterial as super absorber for broadband low-frequency underwater sound.

In this work, an ultrathin acoustic metamaterial formed by space-coiled water channels with a rubber coating is proposed for underwater sound absorption. The proposed metamaterial achieves perfect sound absorption ([Formula: see text] > 0.99) at 181 Hz, which has a deep subwavelength thickness ([Formula: see text]).

Shikonin induces cell autophagy via modulating the microRNA -545-3p/guanine nucleotide binding protein beta polypeptide 1 axis, thereby disrupting cellular carcinogenesis in colon cancer.

Shikonin (SHK), a major component of shiverweed, was provided with anti-tumor effects via multiple targets and signal pathways. Nevertheless, the specific mechanism of its function in colorectal cancer (CRC) still needed to be further explored. The study was designed to examine the role of SHK in CRC and its specific mechanism on the cell tumor behavior of CRC.

Non-periodicity of blood flow and its influence on wall shear stress in the carotid artery bifurcation: An in vivo measurement-based computational study.

Although arterial blood flow is physiologically non-periodic under resting conditions, periodic flow assumption has been widely adopted in most hemodynamic studies. So far, it remains unclear how the non-periodicity of blood flow would influence local hemodynamic parameters, especially wall shear stress (WSS) that associates closely with endothelial function and vascular disease. In this study, numerical simulations of blood flows in sixteen normal carotid artery bifurcations were performed under measured non-periodic and averaged periodic flow conditions, respectively, with the obtained results being compared in terms of five typical WSS metrics (i.