Risk-based triage strategy by extended HPV genotyping for women with ASC-US cytology.

Objective: We attempted to evaluate the immediate high-grade squamous intraepithelial lesion-cervical intraepithelial neoplasia grade 2/3 or worse (HSIL-CIN2+/3+, hereafter referred to as CIN2+/3+) risk of specific human papillomavirus (HPV) genotype and form the precise risk-based triage strategy for atypical squamous cells of undetermined significance (ASC-US) women.

Methods: The clinical data of ASC-US women who underwent HPV genotyping testing and colposcopy were retrospectively reviewed. The distribution and CIN2+/3+ risks of specific HPV genotype were assessed by three approaches.

Alcohol consumption and ambulatory blood pressure-lowering effect in male patients on clinic blood pressure-guided antihypertensive treatment.

In the present analysis, we investigated the association between alcohol consumption and ambulatory blood pressure (BP) control in male patients after 8 weeks of antihypertensive therapy with two dihydropyridine calcium channel blockers. The study participants were hypertensive (clinic systolic/diastolic BP of 140-179/90-109 mmHg and 24-hour ambulatory systolic/diastolic BP ≥ 130/80 mmHg) patients enrolled in a randomized controlled trial and treated with amlodipine 5-10 mg or nifedipine gastrointestinal therapeutic system (GITS) 30-60 mg once daily. Alcohol consumption was classified as non-drinkers and drinkers.

Neuroprotective Indole Alkaloids from the Soil-Derived Fungus sp. XZ8.

A chemical investigation of the soil-derived fungus sp. XZ8 led to the isolation of five new indole alkaloids, trichindoles A-E (-), with diverse architectures, along with seven known analogues (-). Their structures were elucidated by extensive spectroscopic data analysis, and their absolute configurations were determined by single-crystal X-ray diffraction and modified Mosher's method.

Leifsonia stereocauli sp. nov., Isolated from Stereocaulon tomentosum Fr. Lichen.

A Gram-stain-positive, aerobic, yellow-pigmented, catalase-positive, oxidase-positive, non-motile with no flagella and irregularly rod-shaped, denominated strain YIM 134122, was isolated from a Stereocaulon tomentosum Fr. lichen gathered on Baima Snow Mountain in Diqing Tibetan Autonomous Prefecture, Yunnan Province, China. The novel strain grew at pH 6.

Corrigendum: Investigating cutaneous tuberculosis and nontuberculous mycobacterial infections in a Department of Dermatology, Beijing, China: a comprehensive clinicopathological analysis.

[This corrects the article DOI: 10.3389/fcimb.2024.

Sensors for surveillance of RNA viruses: a One Health perspective.

RNA viruses, especially those capable of cross-species transmission, pose a serious threat to human, animal, and environmental health, as exemplified by the 2024 outbreak of the highly pathogenic avian influenza H5N1 virus in cattle, unpasteurised milk, and workers on dairy farms in the USA. This escalating risk of a new RNA virus pandemic highlights the urgent need to implement One Health strategies. However, the centralised virus detection systems currently in use fall short of meeting the required level of virus surveillance and infection diagnosis, particularly in resource-limited regions.

Theoretical insights into the thermoelectric transport performance of the MoPGaS monolayer.

Since the MoSiN monolayer was synthesized experimentally, the family of 2D septuple-layer MoSiN-like materials have attracted widespread attention. However, to date, research on such materials in the thermoelectric field has been rarely reported. In this work, combining first-principles calculations and Boltzmann transport equations, we have investigated the electronic and thermal transport properties of the MoPGaS monolayer.

Organoids as Tools for Investigating Skin Aging: Mechanisms, Applications, and Insights.

Organoids have emerged as transformative tools in biomedical research, renowned for their ability to replicate the complexity construct of human tissues. Skin aging is a multifaceted biological process, influenced by both intrinsic factors and extrinsic factors. Traditional models for studying skin aging often fall short in capturing the intricate dynamics of human skin.

Milder winters would alter patterns of freezing damage for epiphytic lichens from the trans-Himalayas.

Trans-Himalayan winters are projected to become milder, with shifting precipitation patterns and freeze-thaw cycles; changing stressors for their lichen communities. Lichens from Antarctica and high latitudes are cryoresistant when dry, but susceptible to cell damage if frozen when wet, or subjected to repeated freeze-thaw events. Little is known regarding cryoresistance in high-elevation, mid-latitude lichens.

Application of Health Belief Model and Theory of Planned Behavior-Based Care in Patients undergoing Surgery for Limb Fractures.

Aim: This retrospective study aimed to evaluate the effectiveness of a nursing model on the Health Belief Model (HBM) and the Theory of Planned Behavior (TPB) in patients undergoing surgery for limb fractures.

Methods: A total of 100 patients who underwent limb fracture surgery at Zhongnan Hospital of Wuhan University from February 2023 to February 2024 were selected for this study. The research group (n = 58) received nursing care based on the HBM and TPB, while the control group (n = 42) received conventional nursing care.

Fluorescent Tetraphenylethylene-Based Cerium Metal-Organic Frameworks for White-Light-Emitting Diodes.

Discovery of highly efficient and thermal stable phosphors is the focus of the studies in phosphor-converted white light-emitting diodes (LEDs). Herein, a tetraphenylethylene-based cerium metal-organic framework () was synthesized and characterized. The intricate architecture of shows an overall 3D → 3D 2-fold interpenetration framework.

Post-heading dry-matter transport and nutrient uptake differentiate hybrid and inbred indica rice in the double-cropping system in South China.

Introduction: Hybrid rice demonstrated superior performance in enhancing yield and efficiency in rice production compared to inbred rice. Nevertheless, the underlying mechanism responsible for the increased yield and efficiency of hybrid rice in South China's double-cropping rice region remains understudied.

Methods: Field experiments over two consecutive years were conducted.

Wolbachia modify host cell metabolite profiles in response to short-term temperature stress.

Wolbachia are common heritable endosymbionts that influence many aspects of ecology and evolution in various insects, yet Wolbachia-mediated intracellular metabolic responses to temperature stress have been largely overlooked. Here, we introduced the Wolbachia strain wLhui from the invasive Liriomyza huidobrensis (Blanchard) into a Drosophila Schneider 2 cell line (S2) and investigated the metabolite profile of wLhui-infected (S2_wLhui) and uninfected cell lines (S2_wu) under short-term exposure to either high (37°C), moderate (27°C), or low (7 and 17°C) temperatures. We find that Wolbachia infection, temperature stress, and their interactions significantly affect cellular metabolic profiles.

sp. nov. isolated from two lichen species.

Two novel strains, YIM 133132 and YIM 133296, were isolated from lichen samples collected from Yunnan Province, Southwest PR China. YIM 133132 and YIM 133296 are aerobic, Gram-staining-positive, non-motile actinomycetes. They are also catalase-positive and oxidase-negative, and YIM 133132 formed flat yellowish colonies that were relatively dry on YIM38 agar medium.

Blueberry extract attenuates DSS-induced inflammatory bowel disease in mice through inhibiting ER stress-mediated colonic apoptosis in mice.

Inflammatory bowel disease (IBD) is a chronic, debilitating condition with limited therapeutic options. Dietary components like blueberries have emerged as potential modulators of inflammation and tissue repair in gastrointestinal diseases. This study investigated endoplasmic reticulum (ER) stress-mediated apoptosis mediated protective effects of blueberries in ameliorating dextran sulfate sodium (DSS)-induced IBD.

Fungal Coculture of sp. and Induces Production of Diverse Metabolites with Anti-Parkinson's Neuroprotective Activity.

Co-cultivation of isopod-associated fungi sp. SF09 and SF09A led to the reciprocal induction of thirteen new compounds (- and -) with diverse architectures. Importantly, compounds and are rare fungal sesquiterpene-saccharide hybrids incorporating a xylopyranose moiety, compound (±)- represents the first example of a natural linear sesquiterpene racemate, and compound is a rare α-pyrone derivative with a xylopyranose motif.

Polysaccharides Alleviate Depressive-like Symptoms in Chronic Restraint Stress-Induced Mice via Microglial Regulation in Prefrontal Cortex.

Microglia respond to stressors by secreting cytokines or growth factors, playing a crucial role in maintaining brain homeostasis. While the antidepressant-like effects of polysaccharides (PSPs) have been observed in mice, their potential effectiveness involving microglial regulation remains unknown. This study investigates the antidepressant-like mechanism of PSP by regulating microglial phenotype and signaling pathways in the prefrontal cortex of chronic restraint stress (CRS)-induced mice.