The incidence of type 2 diabetes is high, and the existing metformin hydrochloride (MH) tablets of 250 mg cannot meet the demands of the Chinese drug market. This study aimed to evaluate the bioequivalence and safety of generic formulations of MH tablets (test formulation [T], 250 mg/tablet) and innovative products (reference formulation [R], 250 mg/tablet) under fasting conditions. This was an open-label, single-dose, 2-period, 2-sequence crossover, single-center, randomized phase I clinical trial.
View Article and Find Full Text PDFSelenoprotein K (SELENOK) is one of the endoplasmic reticulum (ER) proteins that mainly functions in the regulation of ER stress, calcium flux, and antioxidant defense. Reactive oxygen species (ROS) is one of the key indicators of ferroptosis, and SELENOK inhibition could disrupt ROS balance, and consequently might cause ferroptosis. However, there are no previous studies about the mechanism of SELENOK in ferroptosis by regulating ROS.
View Article and Find Full Text PDFAssessing rangeland productivity is critical to reduce ecological degradation and promote sustainable livestock management. Here, we estimated biomass productivity and carrying capacity dynamics in the Borana rangeland of southern Ethiopia by using field-based data and remote sensing data (i.e.
View Article and Find Full Text PDFAlzheimer's disease (AD), the most common neurodegenerative disease in elderly humans, is pathologically characterized by amyloid plaques and neurofibrillary tangles. Mitochondrial dysfunction that occurs in the early stages of AD, which includes dysfunction in mitochondrial generation and energy metabolism, is considered to be closely associated with AD pathology. Selenomethionine (Se-Met) has been reported to improve cognitive impairment and reduce amyloid plaques and neurofibrillary tangles in 3xTg-AD mice.
View Article and Find Full Text PDFSelenoprotein K (SELENOK), an endoplasmic reticulum (ER) resident protein, is regulated by dietary selenium and expressed at a relatively high level in neurons. SELENOK has been shown to participate in oxidation resistance, calcium (Ca) flux regulation, and the ER-associated degradation (ERAD) pathway in immune cells. However, its role in neurons has not been elucidated.
View Article and Find Full Text PDFZhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
February 2016
Objective: To understand the water infectivity of schistosomes in key water areas of Hanchuan City, and explore the use of sentinel mice in surveillance and forecast of schistosomiasis.
Methods: Surveillance and forecast sites were set up in North Han River, Diaocha Lake, and Miaowu Ditch in 2014. Sentinel mice (male Kunming mice, n=20 in each site) were placed there within the first ten-day period of June and September, respectively.
Three-dimension temporal and spatial dynamics of the soil water characteristics during four irrigating cycles of months from April to July for the artificial vegetation in the center of Taklimakan Desert under saline water drip-irrigation had been analyzed by timely measuring the soil water content in horizontal and vertical distances 60 cm and 120 cm away from the irrigating drips, respectively. Periodic spatial and temporal variations of soil water content were observed. When the precipitation effect was not considered, there were no significant differences in the characteristics of soil water among the irrigation intervals in different months, while discrepancies were obvious in the temporal and spatial changes of soil moisture content under the conditions of rainfall and non-rainfall.
View Article and Find Full Text PDFZhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
December 2014
Objective: To evaluate the effect of comprehensive schistosomiasis control measures based on infection source control in Hanchuan City (marshland and lake endemic regions).
Methods: The data of comprehensive schistosomiasis control in Hanchuan City from 2004 to 2013 were collected, and the change trends of the Oncomelania hupensis snail status and the infection situation of human and livestock were analyzed to evaluate the control effect.
Results: After the implementation of the comprehensive measures, the infection rates of residents and cattle decreased from 6.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
October 2013
Objective: To compare the schistosomiasis control effects of the comprehensive control measures based on infectious resources control and the conventional control measures, so as to provide the evidence for improving prevention and control strategies.
Methods: In the Hanbei River basin, the comprehensive control measures based on infectious resources control (conventional measures plus grazing prohibition in the marshland, machine instead of cattle, and marshland development, and so on) were carned out, and in the Nanzhi River basin, the conventional control measures were performed. The schistosomiasis epidemic data were collected, analyzed and compared from 2004 to 2011.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
October 2013
Ying Yong Sheng Tai Xue Bao
September 2013
By the methods of Biolog, fumigation extraction, and colorimetric titration, this paper determined the soil carbon sources metabolic intensities, microbial biomass, and enzyme activities in the Tarim Desert Highway shelter-forests with different plantation times, and analyzed the variation characteristics of soil microbial activities in these shelter forests. With the increasing planting years of the shelter forests, the soil microbial metabolic activities (AWCD) and microbial diversity indices enhanced obviously, but the AWCD values in different soil layers had no significant differences. The soil catalase activity among the forests had no significant difference, but the soil cellulase and sucrase activities varied significantly.
View Article and Find Full Text PDFLeaves and assimilative branches are crucial to the life cycle of Alhagi sparsifolia Shap. (Fabaceae), which grows in high-irradiance environments and is the main vegetation in the forelands of the Taklamakan Desert. This plant has an important role in wind protection and sand fixation at the oasis-desert transition zone.
View Article and Find Full Text PDFIn order to understand the effects of thinning on the growth of Calligonum arborescens and the soil water-salt distribution in Tarim Desert Highway shelterbelt, a thinning experiment was conducted on an aged and declined C. arborescens woodland in a demonstration section of the shelterbelt, with the growth of C. arborescens and the soil water-salt distribution monitored.
View Article and Find Full Text PDFIn order to ensure the stability and sustainability of the Calligonum mongolicum shelterbelt along Tarim Desert Highway, the aged C. mongolicum was stumped to investigate its growth and soil moisture and salt distribution. After stumping twice, C.
View Article and Find Full Text PDFBy using mcirolysimeter, a laboratory simulation experiment was conducted to study the effects of the grain size and thickness of dust deposits on the soil water evaporation and salt movement in the hinterland of the Taklimakan Desert. Under the same initial soil water content and deposition thickness condition, finer-textured (<0.063 mm) deposits promoted soil water evaporation, deeper soil desiccation, and surface soil salt accumulation, while coarse-textured (0.
View Article and Find Full Text PDFYing Yong Sheng Tai Xue Bao
January 2009
By using correlation analysis, this paper studied the relationships of soil microbial quantity and biomass with soil physical and chemical factors and enzyme activities in highway shelter-forests of Tarim Desert, aimed to approach the interactions between microbes and environmental factors in aeolian sandy soil of extremely arid area. The results showed that soil microbial quantity and biomass in the shelter-forests had an increasing trend with the decrease of soil bulk density and particle size (R < -0.84) and the increase of soil moisture content and porosity (R > 0.
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