MicroRNA-298 determines the radio-resistance of colorectal cancer cells by directly targeting human dual-specificity tyrosine(Y)-regulated kinase 1A.

Background: Radiotherapy stands as a promising therapeutic modality for colorectal cancer (CRC); yet, the formidable challenge posed by radio-resistance significantly undermines its efficacy in achieving CRC remission.

Aim: To elucidate the role played by microRNA-298 (miR-298) in CRC radio-resistance.

Methods: To establish a radio-resistant CRC cell line, HT-29 cells underwent exposure to 5 gray ionizing radiation that was followed by a 7-d recovery period.

Transcriptome-Wide Identification and Prediction of miRNAs and Their Targets in Paris polyphylla var. yunnanensis by High-Throughput Sequencing Analysis.

Long dormancy period of seeds limits the large-scale artificial cultivation of the scarce var. , an important traditional Chinese medicine. Characterizing miRNAs and their targets is crucial to understanding the role of miRNAs during seed dormancy in this species.

[Isolation and identification of Marinobacter adhaerens HY-3 and its allelopathy on Skeletonema costatum].

Unlabelled: The allelopathy between bacteria and algae is a very complicated physical and ecological phenomenon. A marine bacterium was isolated from the water of a shrimp and crab mix-culturing pond. By 16S rRNA analysis, it was identified as Marinobacter adhaerens HY-3.

[Analysis on the frequency of urinary iodine in a population-based intervention study].

Objective: Through a two-year follow up program, this study was to analyze the urinary iodine frequency of a cohort in the intervention trial, concerning different doses of salt ionization, so as to explore the selection of appropriate concentration of salt ionization.

Methods: A multistage cluster sampling method was used to select three townships in two countries for community intervention with different doses [(15±5) mg/kg, (25±5) mg/kg, (35±5) mg/kg] of salt ionization.

Results: After intervention, the median of urinary iodine was reduced among the population.

[Study on the change of urinary iodine of different salt concentrations among the target population in an intervention trial].

Objective: To analyze the change of urinary iodine in a cohort of intervention trial and to observe the role of different doses on salt iodization and related impact factors on nutritional condition of iodine.

Methods: Multistage cluster sampling was used to sample three townships in two counties for community intervention with different doses (15 ± 5, 25 ± 5, 35 ± 5) mg/kg.

Results: Compared to the (35 ± 5) mg/kg group, the urine iodine levels of three experimental townships were gradually declining in county B when time went on, and the (15 ± 5) mg/kg group showed an obvious results, at 6, 12, 18 and 24 months, with the urine iodine level as 180.