Publications by authors named "Xin-qiu Yuan"
Yao Xue Xue Bao
December 2016
Article Synopsis
- The study explored how high temperature (40 ℃) stress affects the size variants and potency of recombinant humanized monoclonal antibody rhumAb1 using various analytical techniques.
- Four size variants identified through SEC-HPLC and seven through non-reduced CE-SDS were analyzed by mass spectrometry, highlighting that low molecular weight variants resulted from fragmentation in the antibody's hinge region.
- Findings indicated that the dimer and fragment variants of rhumAb1 exhibit significantly lower antibody-dependent cell-mediated cytotoxicity (ADCC) compared to the full intact antibody, providing key insights into rhumAb1's stability and potential implications for other monoclonal antibody therapies.
