Asparagine reduces the risk of schizophrenia: a bidirectional two-sample mendelian randomization study of aspartate, asparagine and schizophrenia.

Background: Despite ongoing research, the underlying causes of schizophrenia remain unclear. Aspartate and asparagine, essential amino acids, have been linked to schizophrenia in recent studies, but their causal relationship is still unclear. This study used a bidirectional two-sample Mendelian randomization (MR) method to explore the causal relationship between aspartate and asparagine with schizophrenia.

Plasma levels of hydrogen sulfide and homocysteine correlate with the efficacy of antidepressant agents and serve as potential diagnostic and therapeutic markers.

Objective: Hydrogen sulfide (HS) is associated with depressive-like behavior in rodents. We undertook cross-sectional and longitudinal analyses of plasma levels of HS and its substrate homocysteine (Hcy) in depression and assessed the association of both parameters with psychopathology and cognitive function.

Methods: Forty-one patients suffering from depression (PSDs) and 48 healthy volunteers were recruited.