Magnetic Microbead-Based Herringbone Chip for Sensitive Detection of Human Immunodeficiency Virus.

The microfluidic chip-based nucleic acid detection method significantly improves the sensitivity since it precisely controls the microfluidic flow in microchannels. Nonetheless, significant challenges still exist in improving the detection efficiency to meet the demand for rapid detection of trace substances. This work provides a novel magnetic herringbone (M-HB) structure in a microfluidic chip, and its advantage in rapid and sensitive detection is verified by taking complementary DNA (cDNA) sequences of human immunodeficiency virus (HIV) detection as an example.

Magnetically driven nanorobots based on peptides nanodots with tunable photoluminescence for rapid scavenging reactive α-dicarbonyl species and effective blocking of advanced glycation end products.

The present work constructed magnetically driven nanorobots by conjugating the photoluminescent β-alanine-histidine (β-AH) nanodots to superparamagnetic nanoparticles (SPNPs) for simultaneously sensitive determination and fast trapping RDS in food processing, achieving efficient regulation of advanced glycation end products (AGEs) risk. Bio-derivative β-AH nanodots with orderly self-assembly nanostructure and tunable photoluminescent properties served as both biorecognition elements to effectively bind and scavenge the reactive α-dicarbonyl species (RDS), as well as the indicator with sensitive fluorescence response in the food matrix. The magnetically driven nanorobots with excellent biosafety of endogenous dipeptides displayed a high binding capacity of 80.

Magnetically Controlled Nanorobots Based on Red Emissive Peptide Dots and Artificial Antibodies for Specific Recognition and Smart Scavenging of -(Carboxymethyl)lysine in Dairy Products.

Food-borne advanced glycation end products (AGEs) are highly related to various irreversible diseases, and -(carboxymethyl)lysine (CML) is the typical hazardous AGE. The development of feasible strategies to monitor and reduce CML exposure has become desirable to address the problems. In this work, we proposed magnetically controlled nanorobots by integrating an optosensing platform with specific recognition and binding capability, realizing specific anchoring and accurate determination as well as efficient scavenging of CML in dairy products.

Facile construction of magnetic core-shell covalent organic frameworks as efficient solid-phase extraction adsorbents for highly sensitive determination of sulfonamide residues against complex food sample matrices.

Integration of advanced sample pretreatment techniques, with the involvement of functional nano/micro-materials as adsorbents, is of great importance and value for food-safety precise inspection. For now, the major demands for functional adsorbents are ease of fabrication, fast adsorption and separation performance, low toxicity, robustness, and reusability. In the present work, core-shell structured magnetic covalent organic frameworks (COFs) that employed FeO microspheres as the magnetic core and TpBD COFs as the adsorption shell have been successfully constructed as efficient solid phase extraction (SPE) adsorbents for complex food sample analysis.

Fabrication of an activatable hybrid persistent luminescence nanoprobe for background-free bioimaging-guided investigation of food-borne aflatoxin .

The development of and real-time analytical methods for specifically probing food-borne hazardous substances is promising for clarifying their harmful behaviors and related disease mechanisms inside the living body through investigation of their behaviors. Herein, optical nanoimaging with the ability of non-damage detection and real-time monitoring was introduced for specific recognition of aflatoxin in cellular levels and the fluorescence resonance energy transfer (FRET) protocol. Persistent luminescence nanophosphors (PLNPs) with distinct advantages of improved sensitivity and signal-to-noise ratio were employed in bioimaging as photoluminescence nanoprobes, while copper sulfide nanoparticles were utilized as the quencher.

Spherical covalent organic frameworks as advanced adsorbents for preconcentration and separation of phenolic endocrine disruptors, followed by high performance liquid chromatography.

As a promising generation of porous micro-materials, covalent organic frameworks (COFs) have great potentials for applications in separation and adsorption. In the present study, an advanced food-safety inspection method involving COFs as the adsorbents of solid phase extraction (SPE) is proposed for sensitive and accurate determination of target hazardous substances. Typical spherical TpBD COFs with large surface area and superior chemical stability were utilized as adsorbents for the preconcentration of phenolic endocrine disruptors (PEDs), followed by high performance liquid chromatography (HPLC) analysis.