Dense Convolutional Network and Its Application in Medical Image Analysis.

Dense convolutional network (DenseNet) is a hot topic in deep learning research in recent years, which has good applications in medical image analysis. In this paper, DenseNet is summarized from the following aspects. First, the basic principle of DenseNet is introduced; second, the development of DenseNet is summarized and analyzed from five aspects: broaden DenseNet structure, lightweight DenseNet structure, dense unit, dense connection mode, and attention mechanism; finally, the application research of DenseNet in the field of medical image analysis is summarized from three aspects: pattern recognition, image segmentation, and object detection.

Transcriptome response of maize (Zea mays L.) seedlings to heat stress.

Among stresses, heat stress (HS) is a prime factor restricting plant growth and productivity. However, the molecular mechanisms of plants' response to HS need to be further uncovered. Here, the transcriptome response of maize seedlings to HS was dissected using transcriptome data analysis.

Interplay between hydrogen sulfide and methylglyoxal initiates thermotolerance in maize seedlings by modulating reactive oxidative species and osmolyte metabolism.

Hydrogen sulfide (HS) and methylglyoxal (MG) were supposed to be novel signaling molecules in plants. However, whether interplay between HS and MG can initiate thermotolerance in maize seedlings and in relation to metabolism of reactive oxygen species (ROS) and osmolytes is little known. In this study, watering with MG and NaHS (HS donor) alone or in combination elevated survival and tissue vigor of maize seedlings under heat stress and coped with an increase in the biomembrane injury (as indicated in membrane lipid peroxidation and electrolyte leakage).

Signaling Role of Glutamate in Plants.

It is well known that glutamate (Glu), a neurotransmitter in human body, is a protein amino acid. It plays a very important role in plant growth and development. Nowadays, Glu has been found to emerge as signaling role.

Methylglyoxal triggers the heat tolerance in maize seedlings by driving AsA-GSH cycle and reactive oxygen species-/methylglyoxal-scavenging system.

Traditionally, methylglyoxal (MG) was looked upon as a toxic byproduct of cellular metabolism. Nowadays, MG has been found to be a novel signaling molecule. However, whether MG can trigger the heat tolerance in maize seedlings and the underlying mechanisms is still elusive.

Glutamate signaling enhances the heat tolerance of maize seedlings by plant glutamate receptor-like channels-mediated calcium signaling.

Glutamate (Glu), a neurotransmitter in animal, is a novel signaling molecule in plants, which takes part in cellular metabolism, seed germination, plant growth, development, and long-distance information transfer. However, whether Glu can enhance the heat tolerance in maize seedlings and its relation to calcium signaling is still elusive. In this study, maize seedlings were pretreated with Glu and then exposed to heat stress.

Signaling Molecule Hydrogen Sulfide Improves Seed Germination and Seedling Growth of Maize ( L.) Under High Temperature by Inducing Antioxidant System and Osmolyte Biosynthesis.

Hydrogen sulfide (HS) is a novel type signaling molecule in plants. Seed germination is a key stage of life cycle of plants, which is vulnerable to environmental stress including high temperature. However, under high temperature stress, whether pre-soaking of maize seeds with NaHS (a HS donor) could improve seed germination and seedling growth and the possible mechanisms are not completely clear.

Pharmacokinetics and pharmacodynamics of multiple-dose intravenous nemonoxacin in healthy Chinese volunteers.

This study evaluated the safety and pharmacokinetic/pharmacodynamic profiles of nemonoxacin in healthy Chinese volunteers following multiple-dose intravenous infusion once daily for 10 consecutive days. The study was composed of two stages. In the open-label stage, 500 mg or 750 mg of nemonoxacin (n = 12 each) was administered at an infusion rate of 5.

[Comparative analysis of variable region of white spot syndrome virus genome in Penaeus vannamei in Guangxi, China].

Comparative analysis of variable region ORF14/15 genes of white spot syndrome virus (WSSV) genome in Guangxi Penaeus vannamei (P. vannamei) could provide useful information for the evaluation of genetic diversity and genetic evolutionary relationship among WSSV isolates from Guangxi, China and other places. Based on geographical and temporal considerations, 40 WSSV-positive P.

[Study of pharmacokinetics/pharmacodynamics of levofloxacin].

Objective: To evaluate the dosing regimens of levofloxacin.

Methods: The drug concentrations in serum and urine were assayed by HPLC method and the pharmacokinetic parameters were calculated after intravenous infusion of a single dose of 200 mg, 300 mg and 500 mg levofloxacin to healthy volunteers. The in vitro activity MIC of levofloxacin against 823 clinical isolates were determined and compared with other antimicrobial agents.