Publications by authors named "Xin-Yu Huang"

The straightforward synthesis of noble-metal-nanoparticle-decorated ordered mesoporous transition metal oxides remains a great challenge due to the difficulty of balancing the interactions between precursors and templates. Herein, a solvent-pair-enabled multicomponent coassembly (SPEMC) strategy is developed for straightforward synthesis of noble-metal-nanoparticle-decorated nitrogen-doped ordered mesoporous tungsten oxide (abbreviated as NM/N-mWO, NM = Pt, Rh, Pd). The amphiphilic poly(ethylene oxide)-block-polystyrene (PEO-b-PS) copolymers coassemble with ammonium metatungstate (AMT) clusters and different kinds of hydrophilic noble metal precursors without phase separation.

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  • A new method was developed to quantify enantiomeric barbiturates in serum by combining ultrasound-assisted dispersive liquid-liquid microextraction (UA-DLLME) with large-volume sample stacking (LVSS) in capillary electrophoresis (CE) for improved sensitivity.
  • The process involves optimizing various parameters such as sample preparation at pH 10.0 and using specific buffers to achieve high enrichment efficiencies, ultimately enhancing detection limits to 0.1 ng/mL.
  • The method demonstrated excellent performance with good linearity and low variability in migration times and peak areas, and it was successfully applied to analyze human serum samples.
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  • - The study explores how lime treatment affects the compressibility of soil slurries with high water content, which is important for engineering applications involving soft ground.
  • - Conducted in Southeast China, the research included sixty oedometer tests on lime-treated soils with varying water and lime contents to analyze their deformation properties.
  • - Findings indicate a unique relationship between void ratio, lime content, and initial water content, leading to the establishment of a modified compression index prediction method and a standardized compression curve for certain lime-treated soils.
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  • Ulcerative colitis (UC) is a rising global health issue, characterized by dysfunction in the intestinal barrier and immune response, which poses serious health risks.
  • Research indicates that factors like intestinal mucosal damage, stem cell dysfunction, and gut microbiota imbalance contribute to UC's development.
  • The Notch signaling pathway plays a crucial role in regulating intestinal health by influencing various cells and functions, offering potential therapeutic insights into UC treatment, especially through traditional Chinese medicine approaches.
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  • The text discusses the challenges of synthesizing two-dimensional (2D) mesoporous transition metal oxides and presents a new, rapid method for creating ultrathin 2D mesoporous tin oxide (mSnO) using a Maillard reaction-inspired microexplosion approach.
  • The method involves a reaction between granular ammonia nitrate and melanoidin, which creates carbonaceous templates for the formation of mSnO nanoparticles upon calcination.
  • The resulting ultrathin Pd/mSnO nanocomposites demonstrate excellent sensing capabilities for acetone, featuring high sensitivity and selectivity at low temperatures, highlighting the potential for their use in advanced gas sensors and other applications.
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A novel hybrid composite integrating conductive poly-3-methoxythiophene and PCN-222(Fe) (porphyrin-metal-organic frameworks) was synthesized using an polymerization strategy. Leveraging the large specific area of MOFs and the low electrical resistance of conductive polymers, the modified electrode proved to be a promising candidate for the electrochemical detection of 4-nitrobenzaldehyde. The electrocatalytic response was measured using differential pulse voltammetry techniques and cyclic voltammetry, where the linear concentration range of analyte detection was estimated to be 0-900 μM and the detection limit was 0.

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Organic-inorganic molecular assembly has led to numerous nano/mesostructured materials with fantastic properties, but it is dependent on and limited to the direct interaction between host organic structure-directing molecules and guest inorganic species. Here, we report a "solvent-pair surfactants" enabled assembly (SPEA) method to achieve a general synthesis of mesostructured materials requiring no direct host-guest interaction. Taking the synthesis of mesoporous metal oxides as an example, the dimethylformamide/water solvent pairs behave as surfactants and induce the formation of mesostructured polyoxometalates/copolymers nanocomposites, which can be converted into metal oxides.

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Background: Portal vein thrombosis (PVT) is a serious complication of liver cirrhosis (LC) and is closely related to gut homeostasis. The study aimed to investigate the composition of gut microbiota and its putative role in PVT development in LC.

Methods: 33 patients with LC admitted between January 2022 and December 2022 were enrolled in this study.

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BACKGROUND : Selective biliary cannulation is the most challenging step in endoscopic retrograde cholangiopancreatography (ERCP) because only indirect radiographic images can be obtained. Therefore, we developed a novel endoscopic retrograde direct cholangioscopy (ERDC) technology to facilitate visible biliary cannulation. METHODS : In this case series, we used ERDC to treat 21 patients with common bile duct stones who were enrolled consecutively between July 2022 and December 2022.

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Metal-organic framework (MOF)-derived metal oxide semiconductors have recently received extensive attention in gas sensing applications due to their high porosity and three-dimensional architecture. Still, challenges remain for MOF-derived materials, including low-cost and facile synthetic methods, rational nanostructure design, and superior gas-sensing performances. Herein, a series of Fe-MIL-88B-derived trimetallic FeCoNi oxides (FCN-MOS) with a mesoporous structure were synthesized by a one-step hydrothermal reaction followed by calcination.

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Background: Hematogenous metastasis is essential for the progression of advanced hepatocellular carcinoma (HCC) and can occur even after patients receive multidisciplinary therapies, including immunotherapy and hepatectomy; circulating tumor cells (CTCs) are one of the dominant components of the metastatic cascade. However, the CTC capture efficiency for HCC is low due to the low sensitivity of the detection method. In this study, epithelial cell adhesion molecule (EpCAM)/vimentin/Glypican-3 (GPC3) antibody-modified lipid magnetic spheres (LMS) were used to capture tumor cells with epithelial phenotype, mesenchymal phenotype and GPC3 phenotype, respectively, in order to capture more CTCs with a more comprehensive phenotype for monitoring tumor metastasis.

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Background: Exosomal proteins from cancer cells are becoming new biomarkers for cancer monitoring and efficacy evaluation. However, their biological function and molecular mechanism underlying tumor metastasis are largely unknown.

Methods: Bioinformatic methods such as bulk gene expression analysis, single-cell RNA sequencing data analysis, and gene set enrichment analysis were employed to identify metastasis-associated proteins.

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  • The separation of oily wastewater, particularly emulsions, is an important environmental challenge that calls for sustainable solutions.
  • Researchers developed a superwetting biochar from water caltrop shells, which shows exceptional properties for separating oil and water mixtures.
  • The biochar demonstrated impressive separation efficiency, significantly reducing oil levels in water and achieving high purity in the separated oil, indicating its potential for practical applications in wastewater treatment.
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Advanced exfoliation techniques are crucial for exploring the intrinsic properties and applications of 2D materials. Though the recently discovered Au-enhanced exfoliation technique provides an effective strategy for the preparation of large-scale 2D crystals, the high cost of gold hinders this method from being widely adopted in industrial applications. In addition, direct Au contact could significantly quench photoluminescence (PL) emission in 2D semiconductors.

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  • Hepatocellular carcinoma (HCC) is a major cause of cancer deaths, and effective methods for early detection and prognosis are needed.
  • This study built a Cox regression model using 8 specific genes to predict HCC recurrence, proving effective in risk stratification across multiple patient cohorts.
  • Additionally, the research highlighted the role of identified genes in tumor biology, with some linked to cancer cell functions and others tied to immune response, indicating potential pathways for further investigation in treating HCC.
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Objectives: To propose an updated definition of proximal tibia and fibula fracture (PTFF) and establish a three-dimensional (3D) structure-based classification of PTFF.

Methods: In total, 1358 adult patients (837 males and 521 females; 43.61 ± 15.

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Background: HCC is one of the most common malignancies with an increasing incidence worldwide, especially in Asian countries. However, even though targeted cancer therapy drugs such as sorafenib and regorafenib are available, the overall outcome of HCC remains unsatisfactory. Thus, it is urgent to investigate the molecular mechanisms of HCC progression, so as to provide accurate diagnostic criteria and therapeutic targets.

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Acoustic metamaterials with artificial microstructures are attractive to realize intriguing functions, including efficient waveguiding, which requires large impedance mismatches to realize total side reflection with negligible transmission and absorption. While large impedance mismatch can be readily realized in an air environment, acoustic waveguiding in an underwater environment remains elusive due to insufficient impedance mismatch of state-of-the-art metamaterials. Here, a superhydrophobic acoustic metasurface of microstructured poly(vinylidene fluoride) membrane, referred to as a "meta-skin" insulator, which is able to confine acoustic waves in an all-angle and wide spectrum range due to tremendous impedance mismatch at stable air/water interfaces, viz.

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Background: Exosomes play crucial roles in regulating the crosstalk between normal and cancer cells in the tumor microenvironment, and in regulating cancer proliferation, migration and invasion through their cargo molecules.

Methods: We analyzed the pro-invasiveness of exosomal circRNA-100,338 in HCC using the transwell invasion assay. The co-culture of human umbilical vein endothelial cells (HUVEC) and exosomes derived from HCC cell lines were used to evaluate the impact of HCC derived exosomes on HUVEC.

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  • Muscle-invasive bladder cancer (MIBC) is a serious global health issue, lacking reliable gene signatures for predicting patient outcomes, which are essential for effective clinical evaluations.
  • The study employed advanced statistical models to identify significant gene signatures and developed a risk prediction model, revealing three key genes linked to MIBC prognosis.
  • Findings showed that stratifying patients by risk levels provided better survival predictions; the high-risk group demonstrated poorer outcomes and had genes associated with cancer pathways, suggesting new potential therapeutic targets for treatment.
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  • A study evaluated the safety and effectiveness of phacoemulsification and intraocular lens (IOL) implantation in patients with corneal opacities after deep anterior lamellar keratoplasty (DALK) and cataracts.
  • Twelve eyes from 12 patients showed no complications during or after the procedures, with visual acuity significantly improving post-surgery.
  • The technique involved anterior capsule staining and optical fiber illumination, ensuring stable intraocular pressure and a manageable decrease in endothelial cell density during the follow-up.
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Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. Despite advances in the diagnosis and treatment of HCC, incidence, and mortality continue to rise. For accurate diagnosis and treatment of HCC, there is an urgent need to precisely understand the molecular mechanisms underlying HCC tumorigenesis and progression.

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