Publications by authors named "Xin-Yu Hou"
Survival is one of the foremost endpoints in cancer therapy, and parametric survival analysis could comprehensively demonstrate the overall result of various different baseline and longitudinal factors. In this study, the survival of triple negative breast cancer 4T1 tumor-bearing mice treated by gemcitabine (GEM) and dexamethasone (DEX) was investigated with model-based analysis. The tumor size, lymphocyte (LY) and neutrophil (NE) of 4T1 tumor-bearing BALB/c mice were collected, and the PK/PD models of these longitudinal data were established in a sequential manner, respectively.
View Article and Find Full Text PDFAim: To investigate the molecular mechanisms underlying the influence of hypoxia and alpha-ketoglutaric acid (α-KG) on scleral collagen expression.
Methods: Meta-analysis and clinical statistics were used to prove the changes in choroidal thickness (ChT) during myopia. The establishment of a hypoxic myopia model (HYP) for rabbit scleral fibroblasts through hypoxic culture and the effects of hypoxia and α-KG on collagen expression were demonstrated by Sirius red staining.
Article Synopsis
- Anxiety and depression are common in patients with trigeminal neuralgia (TN), but the underlying neural mechanisms are not well understood.
- Research found a specific neural circuit connecting the ventral hippocampus (vHPC) to the medial prefrontal cortex (mPFC) that influences TN-related anxiety and depression.
- Activation of this circuit increases excitatory signals that lead to depressive-like behaviors, suggesting potential targets for treating anxiety and depression associated with pain.
Transcriptome Analysis of the Mouse Medial Prefrontal Cortex in a Chronic Constriction Injury Model.
Neuromolecular Med
September 2023
The medial prefrontal cortex (mPFC) is critical for both the sensory and emotional/cognitive components of pain. However, the underlying mechanism remains largely unknown. Here, we examined changes in the transcriptomic profiles in the mPFC of mice with chronic pain using RNA sequencing (RNA-seq) technology.
View Article and Find Full Text PDFBackground: One of the most important aspects of drug delivery is extended nanoparticle (NP) residence time in vivo. Herein, we report a series of methotrexate (MTX)-loaded chito-san (CS) NPs coated with differently sized methoxy polyethylene glycol (mPEG) at different mPEG surface densities.
Materials And Methods: MTX was incorporated into NPs (112.