Uncovering immune cell heterogeneity in hepatocellular carcinoma by combining single-cell RNA sequencing with T-cell receptor sequencing.

Background: Understanding the status and function of tumor-infiltrating immune cells is essential for improving immunotherapeutic effects and predicting the clinical response in human patients with carcinoma. However, little is known about tumor-infiltrating immune cells, and the corresponding research results in hepatocellular carcinoma (HCC) are limited.

Aim: To investigate potential biomarker genes that are important for the development of HCC and to understand how immune cell subsets react throughout this process.

[Respiratory sleep monitoring and sleep quality questionnaire survey of Class Ⅱ malocclusion adolescents before and after functional orthodontic treatment].

Purpose: To compare the changes of sleep-breathing parameters and sleep quality before and after treatment of Class Ⅱ malocclusion in adolescents.

Methods: Forty-eight adolescent patients were selected for functional orthodontic treatment. Portable sleep breathing monitor and Pittsburgh sleep quality index(PSQI) were used before treatment, 1 month and 10 months after treatment, in order to compare the results of apnea and hypopnea index(AHI), obstructive apnea index(OAI), central apnea index(CAI), number of hypoventilation (HI), oxygen reduction index (ODI), minimum oxygen index(LSpO) and sleep quality index.

Diastereoselective Generation of C-Azlactonized 2-Chromenes via Brønsted Acid-Catalyzed Oxo-Cyclization of Propargyl Alcohols.

A new Brønsted acid-catalyzed oxo-cyclization of propargyl alcohols with azlactones to synthesize C-azlactonized 2-chromenes has been established that uses 1,1'-binaphthyl-2,2'-diyl hydrogen phosphate (BiNPOH) as the catalyst and gives excellent diastereoselectivities (≥19:1 dr) in most cases. This protocol has a high compatibility with various substituents of substrates, offering a catalytic and useful entry to the fabrication of the synthetically important C-functionalized 2-chromene scaffold.

TTN-AS1 as a potential diagnostic and prognostic biomarker for multiple cancers.

The long noncoding RNAs (lncRNAs) are non-coding RNAs that are more than 200 nucleotides in length, and one of several types of non-coding RNAs (ncRNAs). The lncRNAs function in diverse biological processes in normal cells, such as cellular differentiation and cell cycle regulation. There is also evidence that some aberrantly regulated lncRNAs function as oncogenes or tumor suppressor genes in various cancers.

[Comparison of condylar position between Angle Class I and Class II malocclusion in teenagers].

Purpose: To analyze and compare the difference of condylar position between Angle Class I and Class II malocclusion patients using cone-beam CT (CBCT).

Methods: Thirty Class I patients, 30 Class II division 1 patients and 30 Class II division 2 patients were selected in this study. Each patient underwent CBCT.

The development of hepatocarcinoma after long-term antivirus treatment of Chinese patients with chronic hepatitis B virus infection: Incidence, long-term outcomes and predictive factors.

Background: Patients with chronic hepatitis B virus (HBV) infection are at high risk for progressing to decompensated cirrhosis and hepatocellular carcinoma (HCC). Although long-term treatment with nucleos(t)ide analogues (NAs) benefits patients with chronic hepatitis B (CHB), many develop HCC. Therefore, the clinical outcomes of patients CHB who undergo long-term treatment with NAs remain to be identified.

[Partial recovery of thermal sensory functions in skeletal Class Ⅲ patients undergoing orthognathic surgery].

Purpose: To clarify whether trigeminal somatosensory function will be changed after orthodontic treatment as well as after orthognathic surgery.

Methods: A series of 20 patients with a mean age of 20.9±1.

Hepatitis C virus core protein impairs metabolic disorder of liver cell via HOTAIR-Sirt1 signalling.

It has been suggested that Hepatitis C virus (HCV) core protein is associated with metabolic disorders of liver cell. However, the precise mechanism is still unclear. The aim of the present study was to explore the impact of HCV core protein on hepatocyte metabolism by HepG2 and the possible involvement of long non-coding (lnc) RNAs in this process.