Publications by authors named "Xin-Yi You"
[Metabolomic study on urine of chronic inflammation rats treated with Buyang Huanwu Decoction based on UPLC-Q-TOF-MS].
Zhongguo Zhong Yao Za Zhi
October 2023
The study investigated the effect of Buyang Huanwu Decoction(BYHWD) on endogenous biomarkers in the urine of rats with chronic inflammation induced by lipopolysaccharide(LPS) using ultra-high performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry(UPLC-Q-TOF-MS), aiming to elucidate the molecular mechanism underlying the therapeutic effect of BYHWD on chronic inflammation from a metabolomics perspective. Male SD rats were randomly divided into a normal group, a model group, and low-, medium-, and high-dose BYHWD groups(7.5, 15, and 30 g·kg~(-1)).
View Article and Find Full Text PDFPurpose: To determine whether gross tumor volume (GTV) of adenocarcinoma of esophagogastric junction (AEG) corresponding to cT and cN stages measured on CT could help quantitatively determine resectability.
Materials And Methods: 343 consecutive patients with AEG, including 279 and 64 randomly enrolled in training cohort (TC) and validation cohort (VC), respectively, underwent preoperative contrast-enhanced CT. Univariate and multivariate analyses for TC were performed to determine factors associated with resectability.
Article Synopsis
- Pulmonary fibrosis, commonly seen in various inflammatory lung diseases, currently lacks effective drug treatments.
- Recent studies indicate that wedelolactone (WEL), a key component extracted from certain plants, can protect against pulmonary fibrosis induced by bleomycin in mice.
- Administering WEL significantly reduced inflammation, collagen buildup, and activation of fibrotic markers in the lungs, potentially working through activating the AMPK pathway and inhibiting harmful signaling processes.
Article Synopsis
- - Researchers conducted a gene-based genome-wide association study to find genetic factors influencing lean body mass (LBM) in a sample of 1000 unrelated Caucasian individuals, and later validated their findings in a larger group of 2283 unrelated Caucasians.
- - The study identified three significant genes—UQCR, TCF3, and MBD3—located in a specific genomic region (19p13.3) that showed strong associations with lean mass index (LMI).
- - The results indicate that the 19p13.3 region is a novel genomic locus associated with variations in lean body mass, highlighting the functional importance of these three genes in LBM.
Genomic variants at 20p11 associated with body fat mass in the European population.
Obesity (Silver Spring)
April 2017
Objective: Body fat mass (BFM) is more homogeneous and accurate than body total mass in measuring obesity but has rarely been studied. Aiming to uncover the genetic basis of fat-induced obesity, a genome-wide association meta-analysis of BFM, after adjustment by body lean mass, was performed in the European population.
Methods: Three samples of European ancestry were included in the meta-analysis: the Framingham Heart Study (N = 6,004), the Kansas City osteoporosis study (N = 2,207), and the Omaha osteoporosis study (N = 968).
Ethnopharmacological Relevance: Ecliptae Herba, a nourishing traditional Chinese medicine, is also a folk medicine for the treatment of lung diseases.
Aim Of The Study: To investigate the anti-fibrosis effects and the underlying mechanism of the extract of Ecliptae Herba and its potential active components.
Materials And Methods: The resulting extract (EXT) was prepared from the 80% ethanol extract of Ecliptae Herba.