Publications by authors named "Xin-Yao Xie"
JS-001 is the first monoclonal antibody (mAb) against programmed cell death protein-1 (PD-1) approved by the China Food and Drug Administration (CFDA) into the clinical trails. To date, however, no pre-clinical pharmacological and pharmacokinetic (PK) data are available. In this study, we investigated the efficacy of JS-001 and conducted a preclinical PK study, including the monitoring of anti-drug antibodies (ADAs).
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- There have been three major rabies epidemics in China since the 1950s, with the current one being the focus of this study, which involves isolating rabies viruses (RVs) from dogs and humans.
- The researchers genetically characterized these RV isolates by sequencing key genes and found significant divergence among them, identifying two main clades and multiple lineages within these clades.
- Analysis showed that lineage A viruses in clade I have become predominant over the last decade, indicating they are largely responsible for the ongoing rabies epidemic in China, and these viruses share a recent common ancestor with strains from Southeast Asia.
Sister chromatids separation is under precise regulation during cell cycle. Any turbulence happened in the separation process can cause instability in the transmission of inherited material, and may cause: death or disease of cell or even individual. In eukaryotic cells, one conserved mechanism governs the separation of sister chromatids.
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