Publications by authors named "Xin-Yan Xie"
Article Synopsis
- This study focused on creating machine learning models to identify predictive features of dementia in older adults who initially showed normal cognition.
- Four models were developed and tested, with the random forest model showing the highest accuracy (93%) using factors like memory test results, education, and follow-up time.
- The findings suggest that this machine learning approach can effectively predict dementia in primary healthcare settings, helping to track cognitive changes and enable early intervention.
Article Synopsis
- The study investigates the link between air pollution and the risk of mild cognitive impairment (MCI) in older adults in China, using data from the Hubei Memory and Aging Cohort Study.
- Results show that higher levels of pollutants like PM2.5 and PM10 significantly increase the odds of developing MCI, particularly in older individuals.
- The findings highlight the need for more research across different populations to further understand and address the impact of air pollution on cognitive health in aging populations.
Article Synopsis
- Subjective cognitive decline (SCD) is reported in 58.33% of older adults, with higher rates in rural areas and among females.
- The study involved 7,486 participants aged around 71, assessing correlations between SCD and objective cognitive decline (OCD) across various cognitive functions.
- SCD could indicate early signs of OCD, suggesting the need for preventive measures against dementia, with health and lifestyle factors playing a significant role in increased SCD risk.
Article Synopsis
- * The highest infection rate was found in preweaned calves (33.7%), with lower rates in postweaned calves (24.5%), growing cattle (23.0%), and adults (17.3%).
- * Genetic analysis showed that the majority of infections were due to assemblage E, while mixed infections with assemblage A were also detected; this study establishes important baseline data for managing protozoon infections in dairy cattle.
[Expression and Significance of HOXA9 in Patients with Myelodysplastic Syndromes].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2016
Objective: To investigate the expression pattern of HOXA9 in myelodysplastic syndrome (MDS) patients and its relation with clinical characteristics and treatment response.
Methods: The mRNA and protein expression levels of HOXA9 in bone marrow cells from 33 cases of MDS, 12 cases of AML, 20 cases of ITP and 18 normal controls were detected by real-time guautitative PCR(RT-PCR) and flow cytometry, respectively.
Results: The percentage of HOXA9(+)/CD34(+) and HOXA9(+)/CD34(+)CD38(-) in MDS patients were significantly higher than that in control group (P<0.
[Recent advances of studies on abnormal HOX gene in myelodysplastic syndromes and its molecular mechanisms].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2015
HOX gene encodes a group of homeodomain transcription factors which are highly conserved. The caudal-type homeobox (CDX) , ten-eleven translocation (TET) genes and polycomb group (PcG) , trithorax group (TrxG) proteins act as upstream regulators of HOX genes that manipulate the targeted gene expression through genetic and epigenetic mechanisms. The abnormal expression of HOX genes and their fusions contribute to myelodysplastic syndromes (MDS) pathogenesis.
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