Publications by authors named "Xin-Ya Wei"
Placenta-associated pathologies, including early pregnancy loss (EPL) and preeclampsia (PE), share a common phenomenon of insufficient extravillous trophoblasts (EVTs) invasion. It was previously observed that down-regulated miR-486-5p expression inhibited the invasion of EVTs, and a decreased peripheral miR-486-5p was associated with EPL. However, the exact roles of miR-486-5p played in pathogenesis of EPL, as well as the molecular pathway underlying roles of miR-486-5p in EVTs invasion, remains poorly understood.
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- Decidual macrophages (dMϕs) are crucial for maintaining a stable environment at the maternal-fetal interface during pregnancy, and problems with their function can lead to issues like recurrent spontaneous abortion (RSA).
- The study found that lower levels of SEC5 in primary dMϕs from RSA patients lead to impaired M2 polarization and decreased phosphorylation of STAT6, while higher SEC5 expression enhances these processes.
- SEC5 interacts with STAT6, and reduced SEC5 in macrophages is linked to less effective support for trophoblasts, contributing to early pregnancy loss, as demonstrated in a mouse model.
Ribosomal protein L34-antisense RNA 1 (RPL34-AS1), one of the long non-coding RNAs (lncRNAs), plays an important function in regulating diverse human malignant tumors. Nevertheless, the functions of RPL34-AS1 in ischemic stroke remain unclear. The present work focused on determining the candidate targets of RPL34-AS1 and its related mechanism in ischemic injury.
View Article and Find Full Text PDFBackground: Endoplasmic reticulum stress exists within a tumor. Glucose-regulated protein 94 (GRP94) is a stress-induced chaperone protein involved in tumor development and progression. Its role in myeloma, colon cancer, and other tumors has been confirmed, but its role in lung cancer is unclear.
View Article and Find Full Text PDFObjectives: To determine the effect of acetylcholine (ACh), pilocarpine, and atropine on pain evoked responses of pain excited neurons (PEN) and pain inhibited neurons (PIN) in hippocampal CA3 region of morphine addicted rats.
Materials And Methods: Female Wistar rats, weighing between 230-260 g were used in this study. Morphine addicted rats were generated by subcutaneous injection of increasing concentrations of morphine hydrochloride for six days.