Cystatin C is a moderate predictor of acute kidney injury in the early stage of traumatic hemorrhagic shock.

Patients with traumatic hemorrhagic shock are highly susceptible to the development of acute kidney injury (AKI), but little data are available regarding the changes in cystatin C (CysC) in patients with traumatic hemorrhagic shock. The aim of the present study, therefore, was to investigate whether CysC has a higher value than serum creatinine (SCr) and urea for use in monitoring glomerular function in traumatic hemorrhagic shock. Data from a cohort of patients with traumatic hemorrhagic shock, who had been admitted to a trauma center, were collected.

[Effect of ubiquitin-proteasome pathway on TRAIL inducing apoptosis].

Objective: To determine the influence of ubiquitin-proteasome in regulating the TRAIL-mediated apoptosis.

Methods: RASF cells and SCID mice were divided into 4 groups treated with PBS,anti-DR5, lactacystin, and anti-DR5 plus lactacystin. The apoptosis of cells was detected with Hoechst 33342 and TUNEL.