Nomogram based on clinical and preoperative CT features for predicting the early recurrence of combined hepatocellular-cholangiocarcinoma: a multicenter study.

Purpose: To establish and validate a multiparameter prediction model for early recurrence after radical resection in patients diagnosed with combined hepatocellular-cholangiocarcinoma (cHCC-CC).

Materials And Methods: This study reviewed the clinical characteristics and preoperative CT images of 143 cHCC-CC patients who underwent radical resection from three institutions. A total of 110 patients from institution 1 were randomly divided into training set (n = 78) and testing set (n = 32) in the ratio of 7-3.

Visible-light-induced dual catalysis for -α C(sp)-H amination and alkenylation of -alkyl benzamides.

The amination and alkenylation of the C(sp)-H bond at the -α position of secondary benzamides were both realized in this work by using -hydroxyphthalimide (NHPI) imidate esters as substrates under a dual catalysis involving a photoredox catalyst and hydrogen atom transfer (HAT) catalyst. The developed methods significantly extended the scope of applications of the -α position C(sp)-H bond functionalization with regard to secondary -alkylamides. More importantly, new reaction models in photoredox catalysis have been established.

Selective C(sp)-H bond functionalization of olefins visible-light-induced photoredox-quinuclidine dual catalysis.

The site selective C(sp)-H bond functionalization of olefins has been achieved through a visible-light-induced photoredox-quinuclidine dual catalysis upon merging the quinuclidinium radical cation addition to alkene strategy and the distal heteroaryl -migration strategy. This synthetic protocol features a simple operation with readily available starting materials in good step-economy to access alkenylheteroaromatic products in moderate to good yields under mild conditions. A plausible cascade catalytic reaction mechanism is also proposed.