Improving management in gastroesophageal reflux disease through leveraging WeChat platform for mobile health care: A randomized control trial.

Background: Gastroesophageal reflux disease (GERD) refers to a clinical condition characterized by gastric content reflux into the esophagus, causing symptoms like acid regurgitation and heartburn. While patient education is essential for GERD treatment, traditional educational models often struggle to effectively improve treatment outcomes.

Methods: Between January 2021 and April 2022, we enrolled 257 patients and assessed their GERD knowledge.

Sulforaphane decreases oxidative stress and inhibits NLRP3 inflammasome activation in a mouse model of ulcerative colitis.

Excessive oxidative stress and NLRP3 inflammasome activation are considered the main drivers of inflammatory bowel disease (IBD), and inhibition of inflammasomes ameliorates clinical symptoms and morphological manifestations of IBD. Herein, we examined the roles of NLRP3 activation in IBD and modulation of NLRP3 by sulforaphane (SFN), a compound with multiple pharmacological activities that is extracted from cruciferous plants. To simulate human IBD, we established a mouse colitis model by administering dextran sodium sulfate in the drinking water.

Golf ball-like MoS nanosheet arrays anchored onto carbon nanofibers for electrochemical detection of dopamine.

Arrays of molybdenum(IV) disulfide nanosheets resembling the shape of golf balls (MoS NSBs) were deposited on carbon nanofibers (CNFs), which are shown to enable superior electrochemical detection of dopamine without any interference by uric acid. The MoS NSBs have a diameter of ∼ 2 μm and are made up of numerous bent nanosheets. MoS NSBs are connected by the CNFs through the center of the balls.