Circulating interleukin-27 is associated with the risk of chronic periodontitis and allergic rhinitis: A Mendelian randomization analysis.

Background: Chronic periodontitis (CP) and allergic rhinitis (AR) have attracted wide attention as global public health problems with high incidence. Recent studies have shown that circulating interleukin-27 (IL-27) is associated with the risk of CP and AR. The aim of this study is to analyze the causal effect between them using Mendelian randomization (MR).

[Expression and clinical significance of BTG-1 in 78 patients with oral squamous cell carcinoma].

Purpose: To investigate the expression and clinical significance of B cell translocation gene 1 (BTG1) in oral squamous cell carcinoma(OSCC).

Methods: Immunohistochemical staining was used to detect the expression of BTG1 protein in 78 cases of OSCC tissues, 78 adjacent tissues, 20 normal oral mucosa tissues, and 80 cervical lymph nodes. Western blot and real-time quantitative PCR were used to detect BTG1 protein and mRNA expression levels in 78 OSCC tissues and adjacent tissues.

[Expression and its significance of Cyclin D1 in oral squamous cell carcinoma].

Objective: To investigate the expression and significance of Cyclin D1 in oral squamous cell ma (OSCC).

Methods: A immunohistochemistry method, Envosion, was employed to test the manifesting Cyclin D1 in pathological slices of 50 OSCC cases and 10 normal cases, and the results was treated with statistical lysis.

Results: In 50 OSCC cases, Cyclin D1 mainly manifested in karyon, and a little in cytoplasm.

[Expression and significance of angiopoietins in oral squamous cell carcinoma].

Objective: To observe the expression of angiopoietins in oral squamous cell carcinoma and relationship between the expression of angiopoietins and pathologic classification.

Methods: The expression of Ang-1 and Ang-2 protein in samples from 42 oral squamous cell carcinoma and 16 oral normal mucosa were detected by immunohistochemical technique.

Results: The expression of Ang-1 and Ang-2 was found in both oral squamous cell carcinoma and normal control.