Publications by authors named "Xin-Ran Li"

Porcine circovirus type 3 (PCV3) is endemic in swine worldwide and causes reproductive disorders, dermatitis and nephrotic syndrome, and multi-organ inflammation. PCV3 capsid protein (Cap) can self-assemble into virus-like particles (VLPs), and is an ideal candidate for vaccines and diagnostic reagents.In this study, the recombinant PCV3 Cap protein was successfully expressed in E.

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Hyper-parameter optimization (HPO) aims to improve the performance of machine learning algorithms by identifying appropriate hyper-parameters. By converting the computation of expected improvement into density-ratio estimation problems, existing works use binary classifiers to estimate these ratio and determine the next point by maximizing the class posterior probabilities. However, these methods tend to treat different points equally and ignore some important regions, because binary classifiers are unable to capture more information about search spaces and highlight important regions.

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  • * It finds that the submarine's drift angle significantly affects the flow field, with a 20° drift angle yielding 88% more lateral force and a 61% larger yaw moment compared to a 5° drift angle.
  • * Additionally, the presence of incident waves slightly enhances the submarine's thrust deduction factor and wake fraction, and the research also considers how the waves generated by the submarine's movement affect its propulsion through a Vector AutoRegressive model.
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Purpose: To investigate the inhibitory effect of sodium cantharidate (SCA) on human tongue squamous cell carcinoma CAL27 cells and its mechanism.

Methods: CAL27 cells were pretreated with different concentrations of SCA. Cell viability was analyzed by CCK-8 method.

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Background: Doxorubicin (DOX) is a first-line chemotherapeutic drug for various malignancies that causes cardiotoxicity. Plant-derived exosome-like nanovesicles (P-ELNs) are growing as novel therapeutic agents. Here, we investigated the protective effects in DOX cardiotoxicity of ELNs from Momordica charantia L.

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Background: Hua is a traditional Chinese medicinal food herb which can regulate the liver and Qi, nourish the heart and blood, moisten the lungs and nourish the kidneys with the potential to treat emotional diseases. However, few studies have explored the effects of Hua on postpartum depression. Therefore, we investigated whether processed Hua could improve postpartum depression in rat models by regulating monoamines and hormones.

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  • Researchers studied how Marshall ethanol infusion (VOM-Et) helps when doing a specific heart procedure called mitral isthmus ablation for patients with a heart condition called atrial fibrillation.
  • They compared two groups: one that received VOM-Et alongside another treatment called radiofrequency (RF), and one that only received RF.
  • Results showed that the group with VOM-Et had a much higher success rate (96%) in blocking the intended area compared to the RF only group (76%), and certain factors like being male or older seemed to help the VOM-Et treatment work better.
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Background: Physicians may soon be able to diagnose Alzheimer's disease (AD) in its early stages using fluid biomarkers like amyloid. However, it is acknowledged that additional biomarkers need to be characterized which would facilitate earlier monitoring of AD pathogenesis.

Objective: To determine if a potential novel inflammation biomarker for AD, symmetric dimethylarginine, has utility as a baseline serum biomarker for discriminating prodromal AD from cognitively unimpaired controls in comparison to cerebrospinal fluid amyloid-β42 (Aβ).

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  • A 31-year-old woman had some serious health issues, including heavy periods and anemia, and she ended up needing a medical procedure called a curettage to help with her bleeding.
  • After the procedure, she developed a condition called pulmonary embolism (PE), which is when a blood clot moves to the lungs and can be really dangerous.
  • Doctors treated her PE with special medicine and managed her other issues, and after 6 months, she was doing better without any more problems.
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Purpose: To investigate the value of PAR index combined with cephalometry in evaluating the efficacy of mild to moderate skeletal Class Ⅲ malocclusion.

Methods: Sixty-five adult patients with skeletal Class Ⅲ malocclusion were selected and divided into group C (camouflage therapy) and group S (orthodontic-orthognathic surgery)according to different treatment methods. PAR index and cephalometric values before and after treatment in each group were compared, and then the differences of PAR index and cephalometric values before and after treatment between the two groups were compared.

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Titanium and its alloys are protected by a compact and stable passive film, which confers resistance to corrosion by the primary halogen chloride (Cl) while being less effective against fluoride (F). Although researchers have recognized different macroscopic corrosion effects of these halide ions on titanium, the underlying mechanisms remain largely unexplored. In this work, the bonding of Cl/F with stable passive films was studied in neutral and acidic (pH = 2.

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Background: Aphasia is a debilitating language impairment, affecting millions of people worldwide. About 40% of stroke survivors develop chronic aphasia, resulting in life-long disability.

Objective: This review examines extrinsic and intrinsic neuromodulation techniques, aimed at enhancing the effects of speech and language therapies in stroke survivors with aphasia.

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Neurotoxicity can develop as a side effect of valacyclovir in patients with renal disease, especially without a renally adjusted dose. We present a 56-year-old female with end-stage renal disease (ESRD) on hemodialysis (HD) who presented to the emergency room (ER) with agitation and confusion and was found to have valacyclovir-associated neurotoxicity (VAN). Five days prior, she had been prescribed the standard treatment of 500 mg valacyclovir twice daily for three days for herpes simplex virus-1 (HSV-1); however, her creatinine clearance was low enough to require a renally adjusted dose.

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  • The study investigated the effects of probiotics on intestinal flora and kidney function in mice with chronic kidney disease (CKD).
  • Researchers induced CKD in mice and treated them with the probiotic GG or a placebo for 5 weeks, analyzing both microbial diversity and kidney health.
  • Results showed that probiotic treatment improved kidney function, reduced inflammation markers, and increased the diversity of intestinal flora in CKD mice.
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Typical cockroaches are flat, broad, with large pronotum and wings covering the body. This conserved morphotype dates back to the Carboniferous, during which the ancestral cockroaches, or roachoids, originated. On the other hand, the ovipositor of cockroaches gradually reduced during the Mesozoic, coupled with a major shift of reproductive strategy.

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  • The oxygen reduction reaction (ORR) on titanium (Ti) is complex due to a spontaneously formed oxide film that slows down reaction rates and can cause weak, multi-reaction currents.
  • Researchers used a modified scanning electrochemical microscopy technique to examine how different factors like film characteristics and solution conditions affect Ti's ORR activity and selectivity, achieving a high efficiency of 97.2%.
  • Key findings reveal that reduced Ti enhances selectivity for the desired 4-electron reduction pathway, though quick film regeneration in certain conditions can inhibit overall ORR activity, and anion species significantly impact the reaction outcomes.
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While Mycobacterium tuberculosis is a common bacterial pathogen that infects the respiratory system, especially in endemic regions, it may uncommonly manifest in other organ systems, such as the nervous, gastrointestinal, or musculoskeletal systems. Sacroiliac joint infections are rare, and only 1%-5% of all infections are tuberculous in nature. Given nonspecific inflammatory signs in both laboratory and radiologic examinations, early identification of the causative agent can be difficult.

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  • * Techniques like X-ray scattering, confocal Raman spectroscopy, and molecular dynamics reveal that SO changes fully hydrogen-bonded water into partially hydrogen-bonded water, and this transformation is directly related to the concentration of NaSO.
  • * The findings indicate that SO and Na accumulate in the inner Helmholtz layer, altering ion diffusion and potentially leading to salt scaling on titanium surfaces, thereby providing insight into how the titanium passive film can be damaged by SO.
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Many plants associate with arbuscular mycorrhizal fungi for nutrient acquisition, while legumes also associate with nitrogen-fixing rhizobial bacteria. Both associations rely on symbiosis signaling and here we show that cereals can perceive lipochitooligosaccharides (LCOs) for activation of symbiosis signaling, surprisingly including Nod factors produced by nitrogen-fixing bacteria. However, legumes show stringent perception of specifically decorated LCOs, that is absent in cereals.

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Larval mosquitoes have a more limited home range and lower resistance to adverse environment than adults, thus can be ideal targets for vector control in some cases. Coagulation-flocculation technology, which could be used for water treatment in breeding sites of several vector mosquito species, can significantly change both the distribution of organic particles and surface sediment characteristics in water environment. The aim of this study was to explore the effect, principle and possibility of using coagulation-flocculation technology in immature mosquitoes killing.

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  • Researchers developed a new method using rhodium(III) as a catalyst to create indane-fused pyrrolidine-2,5-diones from aromatic aldehydes and maleimides through a tandem [3+2] cyclization process.
  • The method allows for different product outcomes by simply changing additives and adjusting the reaction time.
  • This efficient process utilizes the activation of C-H bonds without needing nitrogen-based directing groups, works well in air, and shows exclusive stereoselectivity.
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  • Hepatic fibrosis is a condition that results from chronic liver damage and involves activated hepatic stellate cells (HSCs) playing a key role in this process.
  • The study found that β-arrestin2, a protein that helps transmit signals within cells, is increased in liver tissues as fibrosis progresses and is linked to higher collagen levels.
  • By using a mouse model lacking β-arrestin2, researchers showed reduced liver fibrosis and collagen deposition, suggesting that targeting β-arrestin2 could be a potential treatment for hepatic fibrosis.
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The aromatic aldehyde as a traceless directing group for the regionselective C-H alkylation catalyzed by rhodium(III) under aerobic atmospheric conditions has been developed. The process involves an aldehyde assisted direct addition of C-H bond to unsaturated electrophiles of acrylates or acrylic acids, and the subsequent decarbonylation. A trace amount of water is found to favor the reaction.

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The anticipated increasing demand for inactivated foot-and-mouth (FMD) disease vaccine calls for its larger production capacity, while development of a large-scale process typically requires high running cost and has very limited experimental throughput at manufacturing scale. Thus, an economic scale-down model of representing a large-scale process becomes necessary and essential. In this study, we used a systematic approach to establish a scale-down model representing a 4000-L culture process for FMD vaccine production by suspension BHK-21 cells.

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