[The effect of body position changes on lung function, lung CT imaging and pathology in an oleic acid-induced acute lung injury model].

Objective: To study the effect of body position changes on lung mechanics, oxygenation, CT images and pathology in an oleic acid-induced acute lung injury (ALI) model.

Methods: The study groups consisted of one control group and three experimental groups in which the rabbits were put on supine, prone and rotation, respectively. The changes of partial pressure of arterial oxygen (PaO(2)), lung mechanics in the course of the experiment, as well as lung CT and pathology were observed and analyzed.

[Effects of hypercapnia on nuclear factor-kappaB and TNF-alpha in acute lung injury models].

Aim: To observe the effects of hypercapnia on nuclear factor-kappaB and TNF-alpha in acute lung injury models.

Methods: Six of the twenty-two healthy New Zealand white rabbits were randomly allocated to control group (Group C), the other sixteen rabbits were injected with oleic acid (0.1 ml/kg) intravenously, then were randomized to normocapnic group (Group N, n = 8) versus hypercapnic group (Group H, n = 8).