Publications by authors named "Xin-Ming Jiao"
Neuropharmacology
July 2023
Article Synopsis
- Alzheimer's disease (AD) is complex and involves multiple pathways, making multi-targeted inhibitors like ZDWX-12 and ZDWX-25 more effective for treatment.
- Neurofibrillary tangles caused by the Tau protein's hyperphosphorylation, mainly due to GSK3β and DYRK1A overexpression, are a key focus for these inhibitors.
- ZDWX-25 demonstrated superior effectiveness in reducing Tau hyperphosphorylation and neurofibrillary tangles in both cell and mouse models, suggesting it could be a promising drug for Alzheimer’s treatment.
