Synergistic delivery of hADSC-Exos and antioxidants has inhibitory effects on UVB-induced skin photoaging.

Ultraviolet B (UVB) light exposure accelerates skin photoaging. Human adipose-derived stem cell exosomes (hADSC-Exos) and some antioxidants may have anti-photoaging effects. However, it is unknown whether the combination of hADSC-Exos and antioxidants plays a synergistic role in anti-photoaging.

[Analysis of Ozone and VOCs Pollution Characteristics, Sources, and Abatement Control Strategies in Hebi].

In order to control the increasing ozone （O） pollution in Hebi, Henan Province, clarifying the pollution characteristics of ozone and its precursors is vital. Therefore, we conducted a comprehensive analysis of O pollution utilizing the OFP-PMF-EKMA method combined with online hourly resolution monitoring data of conventional pollutants and volatile organic compounds （VOCs） in the summer of 2022 （June-September）. Ozone formation potential （OFP） was used to identify the key VOCs species, and the PMF model was used to identify the VOCs emission sources, whereas EKMA curves and scenario analysis were used to identify the main ozone control area in Hebi and to determine the reduction ratio of VOCs and NO in a scientifically refined way.

Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice.

Background: The transplantation of exosomes derived from human adipose-derived mesenchymal stem cells (hADSCs) has emerged as a prospective cellular-free therapeutic intervention for the treatment of neurodevelopmental disorders (NDDs), as well as autism spectrum disorder (ASD). Nevertheless, the efficacy of hADSC exosome transplantation for ASD treatment remains to be verified, and the underlying mechanism of action remains unclear.

Results: The exosomal long non-coding RNAs (lncRNAs) from hADSC and human umbilical cord mesenchymal stem cells (hUCMSC) were sequenced and 13,915 and 729 lncRNAs were obtained, respectively.

Effects of tumor-infiltrating lymphocytes on nonresponse rate of neoadjuvant chemotherapy in patients with invasive breast cancer.

High level of tumor-infiltrating lymphocytes (TILs) can predict the rate of total pathological complete remission (tpCR) of breast cancer patients who receive neoadjuvant chemotherapy (NACT). This study focused on evaluating the data of patients whose primary tumor and/or lymph node metastasis show nonresponse (NR) to NACT, trying to provide a basis for the clinical decision which patients will develop NACT resistance. The study included breast cancers from 991 patients who received NACT.

Traditional uses, phytochemistry, pharmacology, toxicology, and quality control of Rhododendron dauricum L. leaves: A comprehensive review.

Ethnopharmacological Relevance: Rhododendron dauricum L. is a traditional herb mainly distributed in the northeast China, Mongolia, Korea Peninsula, and Russia Far East. The dried leaves of Rhododendron dauricum L.

Characterization and Phylogenetic Implication of Complete Mitochondrial Genome of the Medicinal Ant Formica sinae (Hymenoptera: Formicidae): Genomic Comparisons in Formicidae.

Ants (Hymenoptera: Formicidae) are among the largest and most widespread families of terrestrial insects and are valuable to medical and ecological investigations. The mitochondrial genome has been widely used as a reliable genetic marker for species identification and phylogenetic analyses. To further understand the mitogenome-level characteristics of the congeneric Formicidae species, the complete mitogenome of Formica sinae (Hymenoptera: Formicidae) was sequenced, annotated, and compared with other 48 Formicidae species.

STAT3 and PD-L1 are negatively correlated with ATM and have impact on the prognosis of triple-negative breast cancer patients with low ATM expression.

Introduction: Triple-negative breast cancer (TNBC) is known for its aggressive behaviors and lacking of effective treatment. Programmed cell death ligand-1 (PD-L1) inhibitor has just been approved for using in the management of advanced TNBC. To accurately screen TNBC sensitive to anti-PD-L1 treatment and to explore the feasibility of the ataxia-telangiectasia mutation protein (ATM) inhibitor combined with PD-L1 inhibitor, radiotherapy and chemotherapy, we focus on whether ATM participates in the regulation of PD-L1 and affects the prognosis of patients through c-Src, signal transducer and activator of transcription 1&3 (STAT1 and STAT3).

Characterization of the complete mitochondrial genome of a harvesting ant (Hymenoptera: Formicidae: Myrmicinae).

(Latreille, 1798) is a keystone ant species in the genus (Formicidae: Myrmicinae). Here, we reported the complete mitochondrial genome of . .

Calcium Signaling Regulated by Cellular Membrane Systems and Calcium Homeostasis Perturbed in Alzheimer's Disease.

Although anything that changes spatiotemporally could be a signal, cells, particularly neurons, precisely manipulate calcium ion (Ca) to transmit information. Ca homeostasis is indispensable for neuronal functions and survival. The cytosolic Ca concentration ([Ca]) is regulated by channels, pumps, and exchangers on cellular membrane systems.

Diterpenoids from the whole plants of Croton yunnanensis and their bioactivities.

Four new 19-nor-clerodane diterpenoids (1-4), one new 15,16-dinor-ent-pimarane diterpenoid (5) together with four known diterpenoids (6-9) were isolated from whole plants of Croton yunnanensis. The structures of these compounds were determined by extensive spectroscopic methods including 1D, 2D NMR, HR-ESI-MS, and by comparing their NMR data with those of previously reported compounds. The experimental and calculated electronic circular dichroism data were used to define their absolute configurations.

Metformin suppresses inflammation and apoptosis of myocardiocytes by inhibiting autophagy in a model of ischemia-reperfusion injury.

Metformin (Met) is a major widely used oral glucose lowering drug for the treatment of type 2 diabetes. It is reported that metformin could regulate autophagy in various diseases of cardiovascular system including in I/R injury, diabetic cardiomyopathy and heart failure. Autophagy plays a controversial role in ischemia/reperfusion (I/R) injury, and this research was performed to explore the cardioprotective effect of Met on I/R injury and discuss the underlying mechanism of autophagy in it.

[Pollution Characteristics of Volatile Organic Compounds Emission from the Metal Packaging Industry Based on Analysis of Process].

This study identified the generation and emission nodes of volatile organic compounds (VOCs) in the metal packaging industry, analyzed the VOCs concentration and species from different production processes, and accounted for secondary pollution through the maximum incremental reactivity method and modified fractional aerosol coefficient method. The results indicated that the main VOCs species were benzenes, alcohols, ketones, and esters, and the benzenes and alcohols contributed more in different types of processes and emission nodes, whereas the ketones and esters contributed less. The maximum concentration was 269.

MG-132 attenuates cardiac deterioration of viral myocarditis via AMPK pathway.

Background: Coxsackievirus B3 (CVB3) is the primary cause of infectious myocarditis. Aggressive immunological activation and apoptosis of myocytes contributes to progressive dysfunction of cardiac contraction and poor prognosis. MG-132, a proteasome inhibitor, regulates mitochondrial-mediated intrinsic myocardial apoptosis and downregulates NF-κB-mediated inflammation.

Four new chemical constituents from Piper pleiocarpum.

Two new polyoxygenated cyclohexenes (1-2), one new benzoate derivative (3), and one new dineolignan (4) together with one known neolignan (5) were isolated from whole plants of Piper pleiocarpum. The structures of these compounds were determined by extensive spectroscopic methods including 1D, 2D NMR, HR-ESI-MS, and by comparison with the literature. The C NMR spectra of the known compound 5 were completely assigned for the first time.

miR-522 facilitates the prosperities of endometrial carcinoma cells by directly binding to monoamine oxidase B.

It is well known that microRNAs (miRNAs) are crucial regulatory factors in tumorigenesis, as tumor suppressors or cancer-promoting factors. However, the study of endometrial carcinoma relevance in miR-522 is rare, indicating an undefined molecular mechanism for its role. Therefore, we performed this study to examine the role of miR-522 on the biological behaviors of endometrial carcinoma.

Pleiocarpumlignan A, a new dineolignan from Chang ex Tseng.

The investigation of chemical constituents from the whole plants Chang ex Tseng resulted in the isolation of one new dineolignan, pleiocarpumlignan A (), along with one known benzoate derivative, -2,3-diacetoxy-1-[(benzoy1oxy)methyl]-cyclohexa-4,6-diene (), and two known neolignans (-) as (±)--dehydrodiisoeugenol (), (7,8,3')-△-3',6'-dihydro-3'-methoxy-3,4-methylenedioxy-6'-oxo-8,3',7,,4'-lignan (). Their structures were elucidated through extensive spectroscopic analyses including 1D, 2D NMR, HR-ESI-MS, and by comparison with the literature. All compounds (-) were firstly isolated from Chang ex Tseng.

[Pollution Characteristics and Health Risk Assessment of Hazardous Air Pollutants in the Surroundings of Three Petrochemical Industries in Northwest China].

The samples in the surroundings of three representative petrochemical industries in Northwest China were collected by summa canister/adsorption using activated carbon/glass fiber filter, and then they were analyzed for 13 hazardous air pollutants by gas chromatography-mass spectrometry/gas chromatograph/high performance liquid chromatography. The pollution characteristics and human health risk of hazardous air pollutants were discussed. The results showed that 8 hazardous air pollutants existed in the surroundings of all petrochemical industries.

Genome-based identification and analysis of ionotropic receptors in Spodoptera litura.

The ability to sense and recognize various classes of compounds is of particular importance for survival and reproduction of insects. Ionotropic receptor (IR), a sub-family of the ionotropic glutamate receptor family, has been identified as one of crucial chemoreceptor super-families, which mediates the sensing of odors and/or tastants, and serves as non-chemosensory functions. Yet, little is known about IR characteristics, evolution, and functions in Lepidoptera.

A new furofuran lignan from Piper terminaliflorum Tseng.

The chemical investigation of whole plants Piper terminaliflorum Tseng led to the isolation of one new furofuran lignan, 7-methoxyasarinin (1), along with three known amide alkaloids (2-4) as N-3,5-dimethoxy-4-hydroxycinnamoylpyrrole (2), dihydropipercide (3) and 1-[(2E,4E,9E)-10-(3,4-Methylenedioxyphenyl)-2,4,9-undecatrienoyl]pyrrolidine (4). Their structures were elucidated by extensive spectroscopic analyses, including 1D, 2D NMR and HR-ESI-MS, and by comparison with the literature. Compounds (2-4) were isolated from Piper terminaliflorum Tseng for the first time.

Stigma receptivity over the lifetime of the hermaphroditic flower of Elsholtzia rugulosa was negatively correlated with pollen viability.

Dichogamy is generally thought to be a mechanism that prevents self-fertilization in flowering plants. This study aims to investigate the relationships between floral age and stigma receptivity, style length and pollen viability, and define how floral characters avoid self-pollination in a gynodioecious Chinese plant, Elsholtzia rugulosa. We assessed the relationships between flower age and style length, stigma receptivity, and pollen viability in E.

Assessment of dual-probe Her-2 fluorescent in situ hybridization in breast cancer by the 2013 ASCO/CAP guidelines produces more equivocal results than that by the 2007 ASCO/CAP guidelines.

Dual-probe fluorescence in situ hybridization (D-FISH) is a widely accepted method to determine the gene amplification status of human epidermal growth factor receptor 2 (Her-2). In 2013, the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) updated the guidelines on the Her-2 testing for invasive breast cancer (BCa). The interpretation criteria for D-FISH changed accordingly.

[Detection of High Molecular Weight Polycyclic Aromatic Hydrocarbons in Mixed Colloid Solution of Spherical Au and Urchin-Like Au-Ag Alloy with Surface-Enhanced Raman Scattering].

In this paper, Au nanosphere and Au-Ag alloy nanourchin were prepared by reducing the chloroauric acid. The mixed colloid solutions of Au nanosphere and Au-Ag alloy nanourchin were used as surface-enhanced Raman scattering (SERS) substrate to detect polycyclic aromatic hydrocarbons (PAHs) in aqueous solution. The size of Au-Ag alloy nanourchin particle was about 300~400 nm and the thorn-like bulge covered on it was about 40~100 nm.

Enhanced differentiation of human amniotic fluid-derived stem cells into insulin-producing cells in vitro.

Aims/introduction: To investigate the ability of human amniotic fluid stem cells (hAFSCs) to differentiate into insulin-producing cells.

Materials And Methods: hAFSCs were induced to differentiate into pancreatic cells by a multistep protocol. The expressions of pancreas-related genes and proteins, including pancreatic and duodenal homeobox-1, insulin, and glucose transporter 2, were detected by polymerase chain reaction and immunofluorescence.

Icariin, a natural flavonol glycoside, extends healthspan in mice.

A major goal of aging research now is to find pharmacological manipulations in healthspan extension. Icariin is a flavonol isolated from medicinal herbal tonics. We have previously reported that icariin extended the healthspan of invertebrate models.