Publications by authors named "Xin-Miao Xue"
Article Synopsis
- - A study analyzed 566 patients with early-stage nasopharyngeal carcinoma (NPC) from 2004 to 2019 to identify independent risk factors linked to the disease.
- - Older age groups, specifically those aged 70-79 and over 80, were found to significantly increase risks of mortality, with hazard ratios indicating higher danger compared to younger patients.
- - Additionally, Asian and Pacific Islander residents had a lower risk of developing early-stage NPC compared to White residents, and smaller tumor sizes (<3 cm) provided better survival rates overall.
Article Synopsis
- Ecto-5'-nucleotidase (NT5E), which encodes CD73, is linked to a tumor microenvironment that suppresses immune responses, leading to worse patient outcomes and increased cancer metastasis and treatment resistance.
- The study analyzed NT5E expression across various cancers, finding that higher levels correlate with poor overall survival in specific cancers, including pancreatic and stomach cancers.
- Additionally, NT5E was associated with increased infiltration of certain immune cells, like cancer-associated fibroblasts, indicating its significant role in tumor progression and the immune landscape.
Protective effect of ginsenoside Rd on military aviation noise-induced cochlear hair cell damage in guinea pigs.
Environ Sci Pollut Res Int
February 2023
Noise pollution has become one of the important social hazards that endanger the auditory system of residents, causing noise-induced hearing loss (NIHL). Oxidative stress has a significant role in the pathogenesis of NIHL, in which the silent information regulator 1(SIRT1)/proliferator-activated receptor-gamma coactivator 1α (PGC-1α) signaling pathway is closely engaged. Ginsenoside Rd (GSRd), a main monomer extract from ginseng plants, has been confirmed to suppress oxidative stress.
View Article and Find Full Text PDFDespite tremendous progress made in the diagnosis and managements, head and neck squamous cell carcinoma (HNSC) remains a global medical dilemma with dismal clinical prognosis and high mortality. Gene NT5E encodes the ecto-5'-nucleotidase (CD73), which facilitates the formation of immunosuppressive tumor microenvironment (TME) permissive for tumor progression in various malignancies. Nevertheless, the cell subsets NT5E expressed on and the potential function of NT5E in the TME of HNSC remain virgin lands in HNSC.
View Article and Find Full Text PDFNoised-induced hearing loss (NIHL) is an acquired, progressive neurological damage caused by exposure to intense noise in various environments including industrial, military and entertaining settings. The prevalence of NIHL is much higher than other occupational injuries in industrialized countries. Recent studies have revealed that genetic factors, together with environmental conditions, also contribute to NIHL.
View Article and Find Full Text PDFFree radicals and oxidative stress play an important role in the pathogenesis of noise-induced hearing loss (NIHL). Some ginseng monomers showed certain therapeutic effects in NIHL by scavenging free radicals. Therefore, we hypothesized that ginsenoside Rd (GSRd) may exert neuroprotective effects after noise-induced auditory system damage through a mechanism involving the SIRT1/PGC-1α signaling pathway.
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